دورية أكاديمية
أعرض في EDS

Blockade of T cell activation induced by the simultaneous absence of Nod1 and Nod2 is bypassed by TLR2 signals.

التفاصيل البيبلوغرافية
العنوان: Blockade of T cell activation induced by the simultaneous absence of Nod1 and Nod2 is bypassed by TLR2 signals.
المؤلفون: Kasimsetty S; Department of Immunology and Microbiology, Scripps Research, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America., Hawkes A; Department of Immunology and Microbiology, Scripps Research, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America., DeWolf SE; Department of Immunology and Microbiology, Scripps Research, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America; Department of Medicine, Division of Pulmonary Medicine, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92037, United States of America., Welch A; Department of Immunology and Microbiology, Scripps Research, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America., McKay DB; Department of Immunology and Microbiology, Scripps Research, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America. Electronic address: dmckay@scripps.edu.
المصدر: Transplant immunology [Transpl Immunol] 2021 Apr; Vol. 65, pp. 101348. Date of Electronic Publication: 2020 Oct 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9309923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5492 (Electronic) Linking ISSN: 09663274 NLM ISO Abbreviation: Transpl Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Dunton Green, Sevenoaks, Kent, UK : Edward Arnold, c1993-
مواضيع طبية MeSH: Nod2 Signaling Adaptor Protein*/genetics , Nod2 Signaling Adaptor Protein*/metabolism , Toll-Like Receptor 2*/metabolism, Lymphocyte Activation ; Receptors, Pattern Recognition/metabolism ; T-Lymphocytes
مستخلص: Pattern recognition receptors (PRRs) trigger adaptive inflammatory responses and as such are attractive targets for therapeutic manipulation of inflammation. In order to develop effective therapies however we need to understand the complexities of PRR signaling and clarify how individual PRRs contribute to an inflammatory response in a given cell type. Data from our lab and others have shown that cross-talk occurs between different PRR family members that directs T cell responses to a particular stimuli. It is well-established that the cell surface toll-like receptor 2 (TLR2) provides a potent costimulatory signal for TCR-stimulated T cell activation. We have shown that signaling through the intracellular nucleotide-binding oligomerization domain-containing proteins 1 and 2 (Nod1 and Nod2) also provides important signals for T cell activation, and that when both Nod1 and Nod 2 are deleted stimulated T cells undergo activation-induced cell death. This study found that TLR2 costimulation could bypass the defect induced by the simultaneous absence of Nods1 and 2 in both antibody- and antigen-stimulated T cells. Since blocking one set of PRR-mediated responses can be overcome by signaling through another PRR family member, then effective therapeutic immune blockade strategies will likely require a multi-pronged approach in order to be effective.
(Copyright © 2020. Published by Elsevier B.V.)
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معلومات مُعتمدة: R01 DK113162 United States DK NIDDK NIH HHS; R01 DK128547 United States DK NIDDK NIH HHS; R21 AI154471 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (Nod2 Signaling Adaptor Protein)
0 (Receptors, Pattern Recognition)
0 (Toll-Like Receptor 2)
تواريخ الأحداث: Date Created: 20210312 Date Completed: 20220113 Latest Revision: 20230815
رمز التحديث: 20230815
مُعرف محوري في PubMed: PMC10425202
DOI: 10.1016/j.trim.2020.101348
PMID: 33706865
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-5492
DOI:10.1016/j.trim.2020.101348