دورية أكاديمية
Role of Presepsin for the Diagnosis of Sepsis and ICU Mortality: A Prospective Controlled Study.
| العنوان: | Role of Presepsin for the Diagnosis of Sepsis and ICU Mortality: A Prospective Controlled Study. |
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| المؤلفون: | Abdelshafey EE; Department of Critical Care Medicine, Alexandria, Egypt.; Department of Intensive Care Unit, Security Forces Hospital, Dammam, Saudi Arabia., Nasa P; Department of Critical Care Medicine, NMC Specialty Hospital, Dubai, United Arab Emirates., Elgohary AE; Department of Intensive Care Unit, Security Forces Hospital, Dammam, Saudi Arabia., Khalil MF; Department of Intensive Care Unit, Security Forces Hospital, Dammam, Saudi Arabia., Rashwan MA; Department of Intensive Care Unit, Security Forces Hospital, Dammam, Saudi Arabia., Ghezala HB; Department of Intensive Care Unit, Security Forces Hospital, Dammam, Saudi Arabia., Tayar AA; Department of Intensive Care Unit, Security Forces Hospital, Dammam, Saudi Arabia. |
| المصدر: | Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine [Indian J Crit Care Med] 2021 Feb; Vol. 25 (2), pp. 153-157. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Jaypee Brothers Medical Publishers Pvt. Ltd. on behalf of Indian Society of Critical Care Medicine Country of Publication: India NLM ID: 101208863 Publication Model: Print Cited Medium: Print ISSN: 0972-5229 (Print) Linking ISSN: 09725229 NLM ISO Abbreviation: Indian J Crit Care Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: New Delhi, India : Jaypee Brothers Medical Publishers Pvt. Ltd. on behalf of Indian Society of Critical Care Medicine Original Publication: Mumbai : Intensive Care Unit, Sir H.N. Hospital : Distributed by Medknow Publications |
| مستخلص: | Background: This study aimed at evaluating the role of presepsin in early identification of sepsis and prediction of mortality in intensive care unit (ICU) patients in comparison to systemic inflammatory response syndrome (SIRS) and quick sequential organ failure assessment (qSOFA) score. Materials and Methods: Forty patients were selected randomly after admission to adult ICU. Data from emergency room (ER) triaging, and initial laboratory results were gathered to calculate qSOFA score, SIRS criteria, and SOFA score. Presepsin measurement was performed within 6 hours from ER triaging.The patients were categorized into sepsis and nonsepsis groups depending on the clinical and microbiological criteria and SOFA score changes. Results: Twenty-six patients were diagnosed as septic with an average age of 68.04 ± 18.60 years, while 14 patients were nonseptic with an average age of 51.71 ± 24.88 years.Presepsin with a cutoff value >640 pg/mL (area under the curve [AUC] of 0.848 ( p < 0.001}) had a significant diagnostic accuracy of identifying septic cases with sensitivity of 73.08% and specificity of 92.86% as compared to the nonsignificant SIRS (AUC, 0.670; sensitivity, 69.23%; and specificity, 57.14%) or qSOFA (AUC, 0.652; sensitivity, 38.46%; and specificity, 78.57%) criteria.Prespsin with a cutoff value >640 pg/mL also significantly (AUC of 0.920 [ p < 0.001]) predicted mortality with sensitivity of 100.0% and specificity of 66.67% compared to the nonsignificant SIRS (AUC, 0.540; sensitivity, 70.0%; and specificity, 43.33%) or qSOFA (AUC, 0.670; sensitivity, 60%; and specificity, 76.67%) criteria. Conclusion: Early presepsin measurement in ICU patients is more accurate in the diagnosis of sepsis and prediction of mortality as compared to SIRS or qSOFA score. How to Cite This Article: Abdelshafey EE, Nasa P, Elgohary AE, Khalil MF, Rashwan MA, Ghezala HB, et al. Role of Presepsin for the Diagnosis of Sepsis and ICU Mortality: A Prospective Controlled Study. Indian J Crit Care Med 2021;25(2):153-157. Competing Interests: Source of support: Nil Conflict of interest: None (Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.) |
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| فهرسة مساهمة: | Keywords: Biomarkers; Predictive model; Presepsin; Sepsis; qSOFA: quick sequential (sepsis-related) organ failure assessment |
| تواريخ الأحداث: | Date Created: 20210312 Latest Revision: 20220421 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7922455 |
| DOI: | 10.5005/jp-journals-10071-23715 |
| PMID: | 33707892 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0972-5229 |
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| DOI: | 10.5005/jp-journals-10071-23715 |