دورية أكاديمية
أعرض في EDS

Genetic basis of susceptibility to low-dose paraquat and variation between the sexes in Drosophila melanogaster.

التفاصيل البيبلوغرافية
العنوان: Genetic basis of susceptibility to low-dose paraquat and variation between the sexes in Drosophila melanogaster.
المؤلفون: Lovejoy PC; Department of Biological Sciences, Binghamton University, Binghamton, NY, USA.; Department of Biology, St. Joseph's College, Brooklyn, NY, USA., Foley KE; Department of Biological Sciences, Binghamton University, Binghamton, NY, USA., Conti MM; Department of Psychology, Binghamton University, Binghamton, NY, USA., Meadows SM; Department of Psychology, Binghamton University, Binghamton, NY, USA., Bishop C; Department of Psychology, Binghamton University, Binghamton, NY, USA., Fiumera AC; Department of Biological Sciences, Binghamton University, Binghamton, NY, USA.
المصدر: Molecular ecology [Mol Ecol] 2021 May; Vol. 30 (9), pp. 2040-2053. Date of Electronic Publication: 2021 Mar 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9214478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-294X (Electronic) Linking ISSN: 09621083 NLM ISO Abbreviation: Mol Ecol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Blackwell Scientific Publications, c1992-
مواضيع طبية MeSH: Drosophila Proteins*/genetics , Drosophila melanogaster*/genetics, Animals ; Drosophila ; Female ; Genetic Variation ; Genome-Wide Association Study ; Male ; Paraquat/toxicity
مستخلص: Toxicant resistance is a complex trait, affected both by genetics and the environment. Like most complex traits, it can exhibit sexual dimorphism, yet sex is often overlooked as a factor in studies of toxicant resistance. Paraquat, one such toxicant, is a commonly used herbicide and is known to produce mitochondrial oxidative stress, decrease dopaminergic neurons and dopamine (DA) levels, and decrease motor ability. While the main effects of paraquat are well-characterized, less is known about the naturally occurring variation in paraquat susceptibility. The purpose of this study was to map the genes contributing to low-dose paraquat susceptibility in Drosophila melanogaster, and to determine if susceptibility differs between the sexes. One hundred of the Drosophila Genetic Reference Panel (DGRP) lines were scored for susceptibility via climbing ability and used in a genome-wide association study (GWAS). Variation in seventeen genes in females and thirty-five genes in males associated with paraquat susceptibility. Only two candidate genes overlapped between the sexes despite a significant positive correlation between male and female susceptibilities. Many associated polymorphisms had significant interactions with sex, with most having conditionally neutral effects. Conditional neutrality between the sexes probably stems from sex-biased expression which may result from partial resolution of sexual conflict. Candidate genes were verified with RNAi knockdowns, gene expression analyses, and DA quantification. Several of these genes are novel associations with paraquat susceptibility. This research highlights the importance of assessing both sexes when studying toxicant susceptibility.
(© 2021 John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: DGRP; climbing ability; conditional neutrality; genetic architecture; resistance; sexual dimorphism
المشرفين على المادة: 0 (Drosophila Proteins)
PLG39H7695 (Paraquat)
تواريخ الأحداث: Date Created: 20210312 Date Completed: 20210621 Latest Revision: 20210621
رمز التحديث: 20240628
DOI: 10.1111/mec.15878
PMID: 33710693
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-294X
DOI:10.1111/mec.15878