دورية أكاديمية
أعرض في EDS

Prognostic value of FUS immunoexpression for Gleason patterns and prostatic adenocarcinoma progression.

التفاصيل البيبلوغرافية
العنوان: Prognostic value of FUS immunoexpression for Gleason patterns and prostatic adenocarcinoma progression.
المؤلفون: Hirth CG; Department of Pathology and Forensic Medicine, Postgraduate Program in Medical-Surgical Sciences of the Department of Surgery of the Federal University of Ceará, Hospital Haroldo Juaçaba, Ceará Cancer Institute, Brazil. Electronic address: carlos.hirth@ufc.br., Vasconcelos GR; Hospital Haroldo Juaçaba, Ceará Cancer Institute, Pathology Laboratory, 1222, Papi Junior St. Rodolfo Teófilo, Fortaleza, Ceará 60351-010, Brazil., Lima MVA; Hospital Haroldo Juaçaba, Ceará Cancer Institute, Rodolfo Teófilo College, 1222, Papi Junior St. Rodolfo Teófilo, Fortaleza, Ceará 60351-010, Brazil., da Cunha MDPSS; Hospital Haroldo Juaçaba, Ceará Cancer Institute, Urology Clinical, Rodolfo Teófilo College, Albert Sabin Hospital, 1222, Papi Junior St. Rodolfo Teófilo, Fortaleza, Ceará 60351-010, Brazil., Frederico IKS; Hospital Haroldo Juaçaba, Ceará Cancer Institute, Pathology Laboratory, 1222, Papi Junior St. Rodolfo Teófilo, Fortaleza, Ceará 60351-010, Brazil., Dornelas CA; Department of Pathology and Forensic Medicine and Department of Surgery, Postgraduate Program in Medical-Surgical Sciences of the Department of Surgery of the Federal University of Ceará, Departamento de Patologia e Medicina Legal, Universidade Federal do Ceará, Rua Monsenhor Furtado, s/n, Rodolfo Teófilo, Fortaleza, Ceará 60441-750, Brazil.
المصدر: Annals of diagnostic pathology [Ann Diagn Pathol] 2021 Jun; Vol. 52, pp. 151729. Date of Electronic Publication: 2021 Mar 01.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: W.B. Saunders Co Country of Publication: United States NLM ID: 9800503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8198 (Electronic) Linking ISSN: 10929134 NLM ISO Abbreviation: Ann Diagn Pathol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : W.B. Saunders Co., c1997-
مواضيع طبية MeSH: Adenocarcinoma/*metabolism , Neoplasm Grading/*statistics & numerical data , RNA-Binding Protein FUS/*genetics, Adenocarcinoma/diagnosis ; Biomarkers, Tumor/metabolism ; Biopsy ; Disease Progression ; Humans ; Male ; Neoplasm Grading/methods ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Prostatectomy/methods ; Prostatic Neoplasms/pathology ; RNA-Binding Protein FUS/metabolism ; Retrospective Studies ; Salvage Therapy ; Tissue Array Analysis/methods
مستخلص: Background: Risk assessment is important when planning treatment for prostatic adenocarcinoma. Gleason score is a strong predictor of disease progression, despite the possibility of mismatches between biopsy and prostatectomy. In order to increase the accuracy of Gleason scores, several markers have been proposed. One of these, FUS (fused in sarcoma), plays a role in RNA processing, chromosome stability and gene transcription.
Patients and Methods: Non-neoplastic tissue and Gleason pattern 3, 4 and 5 adenocarcinoma samples were submitted to tissue microarrays. Gleason pattern 3 and 4 were compared to the final Gleason score. We also conducted univariate and multivariate tests to probe the association between FUS expression in adenocarcinoma samples and outcome: biochemical persistence and biochemical recurrence (separately or pooled as biochemical progression), biochemical failure after salvage radiotherapy, and systemic progression.
Results: Our cohort consisted of 636 patients. Non-neoplastic tissue stained less frequently (36.5%) than neoplastic tissue (47.4%), with expression increasing from Gleason pattern 3 towards pattern 5. FUS-positive Gleason pattern 3 was significantly associated with final Gleason scores >6 (HR = 1.765 [1.203-2.589]; p = 0.004). Likewise, FUS-positive Gleason pattern 4 was significantly associated with final Gleason scores ≥7 (4 + 3). The association between FUS positivity and biochemical persistence and recurrence observed in the univariate analysis was not maintained in the multivariate analysis (HR = 1.147 [0.878-1.499]; p = 0.313).
Conclusion: Non-neoplastic tissue was less frequently FUS-positive than neoplastic tissue. FUS positivity in Gleason pattern 3 and 4 increased the risk of high grade adenocarcinoma and was associated with clinical/laboratory progression in the univariate, but not in multivariate analysis.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Biochemical persistence; Biochemical recurrence; Cancer prognosis; Fused in Sarcoma (FUS); Gleason score; Metastatic prostatic neoplasm; Prostatic neoplasm
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (FUS protein, human)
0 (RNA-Binding Protein FUS)
تواريخ الأحداث: Date Created: 20210313 Date Completed: 20211124 Latest Revision: 20211124
رمز التحديث: 20221213
DOI: 10.1016/j.anndiagpath.2021.151729
PMID: 33713944
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-8198
DOI:10.1016/j.anndiagpath.2021.151729