دورية أكاديمية
Methanol Extract of Mongolian Iris bungei Maxim. Stimulates 3T3-L1 Adipocyte Differentiation.
| العنوان: | Methanol Extract of Mongolian Iris bungei Maxim. Stimulates 3T3-L1 Adipocyte Differentiation. |
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| المؤلفون: | Yeon J; Department of Biosciences, Mokpo National University, Muan 58554, Republic of Korea., Suh SS; Department of Biosciences, Mokpo National University, Muan 58554, Republic of Korea., Youn UJ; Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea., Bazarragchaa B; Department of Environment & Forest Resources, Chungnam National University, Daejeon 34134, Republic of Korea., Enebish G; Department of Biology, Ulaanbaatar State University, Ulaanbaatar 13343, Mongolia., Seo JB; Department of Biosciences, Mokpo National University, Muan 58554, Republic of Korea. |
| المصدر: | Journal of nanoscience and nanotechnology [J Nanosci Nanotechnol] 2021 Jul 01; Vol. 21 (7), pp. 3943-3949. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Scientific Publishers Country of Publication: United States NLM ID: 101088195 Publication Model: Print Cited Medium: Internet ISSN: 1533-4899 (Electronic) Linking ISSN: 15334880 NLM ISO Abbreviation: J Nanosci Nanotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Stevenson Ranch, CA : American Scientific Publishers, 2001-2021 |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2* , Iris Plant*, 3T3-L1 Cells ; Adipocytes ; Adipogenesis ; Animals ; Cell Differentiation ; China ; Gene Expression Regulation ; Lipid Metabolism ; Methanol ; Mice ; Plant Extracts/pharmacology |
| مستخلص: | Iris bungei Maxim. (IB), which is native to China and Mongolia, is used as a traditional medicine for conditions such as inflammation, cancer, and bacterial infections. However, the effects of Iris bungei Maxim. on adipocyte differentiation have not been studied. In the present study, we first demonstrated the molecular mechanisms underlying the adipogenic activity of the methanol extract of Mongolian I. bungei Maxim. (IB). IB significantly enhanced intracellular lipid accumulation and adipocyte differentiation in 3T3-L1 preadipocytes in a concentration-dependent manner. Moreover, IB markedly stimulated the expression of genes related to adipogenesis such as peroxisome proliferator-activated receptor γ, adiponectin, and aP2. In addition, we also observed that IB induces lipogenic genes such as fatty acid synthase, sterol regulatory element binding protein 1c, stearoyl-CoA desaturase, and acetyl-CoA carboxylase. Interestingly IB regulated adipocyte differentiation in both the early and middle stages. Taken together, these adipogenic and lipogenic effects of IB suggest its efficacy for the prevention and/or treatment of type 2 diabetes. |
| المشرفين على المادة: | 0 (Plant Extracts) Y4S76JWI15 (Methanol) |
| تواريخ الأحداث: | Date Created: 20210315 Date Completed: 20210628 Latest Revision: 20210628 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1166/jnn.2021.19160 |
| PMID: | 33715722 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1533-4899 |
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| DOI: | 10.1166/jnn.2021.19160 |