دورية أكاديمية
Liver fibrosis in patients with tetralogy of Fallot, an unrecognised complication?
| العنوان: | Liver fibrosis in patients with tetralogy of Fallot, an unrecognised complication? |
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| المؤلفون: | Ravndal MEH; Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Cardiothoracic Surgery, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Borgwardt L; Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Juul K; Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Nielsen J; Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Borgwardt L; Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Henriksen BM; Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Willemoe GL; Department of Pathology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Jensen AS; Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Christensen VB; Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Kjær MS; Department of Gastroenterology and Hepatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. |
| المصدر: | Cardiology in the young [Cardiol Young] 2021 Nov; Vol. 31 (11), pp. 1796-1806. Date of Electronic Publication: 2021 Mar 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 9200019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-1107 (Electronic) Linking ISSN: 10479511 NLM ISO Abbreviation: Cardiol Young Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005->: Cambridge : Cambridge University Press Original Publication: Chapel Hill, NC : World Publishers, c1991- |
| مواضيع طبية MeSH: | Heart Defects, Congenital*/complications , Heart Defects, Congenital*/diagnostic imaging , Pulmonary Valve Insufficiency* , Tetralogy of Fallot*/complications , Tetralogy of Fallot*/diagnostic imaging , Tetralogy of Fallot*/surgery, Humans ; Liver Cirrhosis/complications |
| مستخلص: | Objectives: Improved survival has led to a growing population of adults with congenital heart disease (CHD), followed by numerous reports of late complications. Liver disease is a known complication in some patients, with most studies focusing on Fontan associated liver disease. Whether liver disease also exists in other patients with CHD is not fully investigated. Elevated central venous pressure is considered pivotal in the development of liver disease in Fontan associated liver disease, and other patients with alterations in central venous pressure may also be at risk for developing liver fibrosis. We wanted to see if liver fibrosis is present in patients with tetralogy of Fallot. Many patients with tetralogy of Fallot have severe pulmonary regurgitation, which can lead to elevated central venous pressure. Patients with tetralogy of Fallot may be at risk of developing liver fibrosis. Materials and Methods: Ten patients (24-56 years) with tetralogy of Fallot and pulmonary regurgitation were investigated for liver fibrosis. All patients were examined with magnetic resonance elastography of liver, hepatobiliary iminodiacetic acid scan, indocyanine green elimination by pulse spectrophotometry, elastography via FibroScan, abdominal ultrasound including liver elastography, and blood samples including liver markers. Results: Three out of ten patients had findings indicating possible liver fibrosis. Two of these had a liver biopsy performed, which revealed fibrosis stage 1 and 2, respectively. The same three patients had an estimated elevated central venous pressure in previous echocardiograms. Conclusions: Mild liver fibrosis was present in selected patients with tetralogy of Fallot and may be related to elevated central venous pressure. |
| فهرسة مساهمة: | Keywords: Liver fibrosis; congenital heart disease; hepatocellular carcinoma; liver complications; tetralogy of Fallot |
| تواريخ الأحداث: | Date Created: 20210315 Date Completed: 20211122 Latest Revision: 20211122 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1017/S1047951121000901 |
| PMID: | 33719984 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1467-1107 |
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| DOI: | 10.1017/S1047951121000901 |