دورية أكاديمية
USPIO-enhanced MRI of lymph nodes in rectal cancer: A node-to-node comparison with histopathology.
| العنوان: | USPIO-enhanced MRI of lymph nodes in rectal cancer: A node-to-node comparison with histopathology. |
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| المؤلفون: | Stijns RCH; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Surgery, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: Rutger.Stijns@radboudumc.nl., Philips BWJ; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., Nagtegaal ID; Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands., Polat F; Department of Surgery, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands., de Wilt JHW; Department of Surgery, Radboud University Medical Center, Nijmegen, the Netherlands., Wauters CAP; Department of Pathology, Canisius-Wilhelmina Hospital, Nijmegen, the Netherlands., Zamecnik P; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., Fütterer JJ; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands., Scheenen TWJ; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Erwin L. Hahn Institute for MR Imaging, University of Duisburg-Essen, Essen, 45141, Germany. |
| المصدر: | European journal of radiology [Eur J Radiol] 2021 May; Vol. 138, pp. 109636. Date of Electronic Publication: 2021 Mar 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 8106411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7727 (Electronic) Linking ISSN: 0720048X NLM ISO Abbreviation: Eur J Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Science Ireland Ltd Original Publication: Stuttgart ; New York : Thieme, [c1981- |
| مواضيع طبية MeSH: | Magnetite Nanoparticles* , Rectal Neoplasms*/diagnostic imaging , Rectal Neoplasms*/pathology, Contrast Media ; Dextrans ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Magnetic Resonance Imaging ; Neoplasm Staging |
| مستخلص: | Purpose: To evaluate the initial results of predicting lymph node metastasis in rectal cancer patients detected in-vivo with USPIO-enhanced MRI at 3 T compared on a node-to-node basis with histopathology. Methods: Ten rectal cancer patients of all clinical stages were prospectively included for an in-vivo 0.85 mm 3 isotropic 3D MRI after infusion of Ferumoxtran-10. The surgical specimens were examined ex-vivo with an 0.29 mm 3 isotropic MRI examination. Two radiologists evaluated in-vivo MR images with a classification scheme to predict lymph node status. Ex-vivo MRI was used for MR-guided pathology and served as a key link between in-vivo MRI and final histopathology for the node-to-node analysis. Results: 138 lymph nodes were detected by reader 1 and 255 by reader 2 (p = 0.005) on in-vivo MRI with a median size of 2.6 and 2.4 mm, respectively. Lymph nodes were classified with substantial inter-reader agreement (κ = 0.73). Node-to-node comparison was possible for 55 lymph nodes (median size 3.2 mm; range 1.2-12.3), of which 6 were metastatic on pathology. Low true-positive rates (3/26, 11 % for both readers) and high true negative rates were achieved (14/17, 82 %; 19/22, 86 %). Pathological re-evaluations of 20 lymph nodes with high signal intensity on USPIO-enhanced MRI without lymph node metastases (false positives) did not reveal tumor metastasis but showed benign lymph node tissue with reactive follicles. Conclusions: High resolution MRI visualizes a large number of mesorectal lymph nodes. USPIO-enhanced MRI was not accurate for characterizing small benign versus small tumoral lymph nodes in rectal cancer patients. Suspicious nodes on in-vivo MRI occur as inflammatory as well as metastatic nodes. (Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Lymph node; Magnetic resonance imaging; Metastasis; Rectal cancer; USPIO |
| المشرفين على المادة: | 0 (Contrast Media) 0 (Dextrans) 0 (Magnetite Nanoparticles) 0 (ferumoxtran-10) |
| تواريخ الأحداث: | Date Created: 20210315 Date Completed: 20210419 Latest Revision: 20210419 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.ejrad.2021.109636 |
| PMID: | 33721766 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7727 |
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| DOI: | 10.1016/j.ejrad.2021.109636 |