دورية أكاديمية
Biosensor based on two-dimensional gradient guided-mode resonance filter.
| العنوان: | Biosensor based on two-dimensional gradient guided-mode resonance filter. |
|---|---|
| المؤلفون: | Yang NZ, Hsiung CT, Huang CS |
| المصدر: | Optics express [Opt Express] 2021 Jan 18; Vol. 29 (2), pp. 1320-1332. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Optica Publishing Group Country of Publication: United States NLM ID: 101137103 Publication Model: Print Cited Medium: Internet ISSN: 1094-4087 (Electronic) Linking ISSN: 10944087 NLM ISO Abbreviation: Opt Express Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Optica Publishing Group Original Publication: Washington, DC : Optical Society of America, 1997- |
| مواضيع طبية MeSH: | Albumins/*analysis , Biosensing Techniques/*instrumentation , Photometry/*instrumentation , Refractometry/*instrumentation , Sucrose/*analysis , Surface Plasmon Resonance/*instrumentation, Equipment Design |
| مستخلص: | A novel biosensor based on a two-dimensional gradient (TDG) guided-mode resonance (GMR) filter was introduced in this study. The TDG-GMR is demarcated in terms of the gradient grating period (GGP) in one dimension and gradient waveguide thickness (GWT) in the other dimension. A single compact sensor can combine these two features to simultaneously provide a broad detection range through GGP and high resolution through GWT. A detection range of 0.109 RIU (0%-60% sucrose content) with a limit of detection of 5.62 × 10 -4 was demonstrated in this study by using a TDG-GMR with a size of 140.8 × 125.4 µm 2 . This value cannot be achieved using one dimensional gradient GMR sensor. Label-free (LF) biomolecule detection through TDG-GMR was also experimentally demonstrated in a model assay of albumin. The result confirms that the GWT-GMR provides a better resolution, whereas the GGP-GMR provides a broader detection range. A device for multiplex measurement could be easily implemented with a compact sensor chip and a simple readout directly from a charge-coupled device. This system would require a narrow-band source such as a light emitting diode or a laser diode, in addition to a limited number of other components such as a polarizer and a collimator. The proposed TDG-GMR could easily be integrated with smartphones and portable devices. |
| المشرفين على المادة: | 0 (Albumins) 57-50-1 (Sucrose) |
| تواريخ الأحداث: | Date Created: 20210317 Date Completed: 20211022 Latest Revision: 20211022 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1364/OE.408597 |
| PMID: | 33726350 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1094-4087 |
|---|---|
| DOI: | 10.1364/OE.408597 |