دورية أكاديمية
Cholinergic regulation of adult hippocampal neurogenesis and hippocampus-dependent functions.
| العنوان: | Cholinergic regulation of adult hippocampal neurogenesis and hippocampus-dependent functions. |
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| المؤلفون: | Madrid LI; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia., Jimenez-Martin J; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia., Coulson EJ; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia., Jhaveri DJ; Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia. Electronic address: dhanisha@uq.edu.au. |
| المصدر: | The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2021 May; Vol. 134, pp. 105969. Date of Electronic Publication: 2021 Mar 13. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9508482 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5875 (Electronic) Linking ISSN: 13572725 NLM ISO Abbreviation: Int J Biochem Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Exeter, England ; Tarrytown, NY, U.S.A. : Pergamon, c1995- |
| مواضيع طبية MeSH: | Cholinergic Agents/*pharmacology , Cognition/*physiology , Hippocampus/*physiology , Neurons/*physiology, Adult ; Animals ; Cognition/drug effects ; Hippocampus/drug effects ; Humans ; Neurogenesis ; Neuronal Plasticity ; Neurons/drug effects |
| مستخلص: | The production and circuit integration of new neurons is one of the defining features of the adult mammalian hippocampus. A wealth of evidence has established that adult hippocampal neurogenesis is exquisitely sensitive to neuronal activity-mediated regulation. How these signals are interpreted and contribute to neurogenesis and hippocampal functions has been a subject of immense interest. In particular, neurotransmitters, in addition to their synaptic roles, have been shown to offer important trophic support. Amongst these, acetylcholine, which has a prominent role in cognition, has been implicated in regulating neurogenesis. In this review, we appraise the evidence linking the contribution of cholinergic signalling to the regulation of adult hippocampal neurogenesis and hippocampus-dependent functions. We discuss open questions that need to be addressed to gain a deeper mechanistic understanding of the role and translational potential of acetylcholine and its receptors in regulating this form of cellular neuroplasticity. (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Acetylcholine; Adult neurogenesis; Behaviour; Cholinergic receptors; Cognition; Hippocampus |
| المشرفين على المادة: | 0 (Cholinergic Agents) |
| تواريخ الأحداث: | Date Created: 20210317 Date Completed: 20210928 Latest Revision: 20210928 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.biocel.2021.105969 |
| PMID: | 33727042 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-5875 |
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| DOI: | 10.1016/j.biocel.2021.105969 |