دورية أكاديمية
Variants associated with HHIP expression have sex-differential effects on lung function.
| العنوان: | Variants associated with HHIP expression have sex-differential effects on lung function. |
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| المؤلفون: | Fawcett KA; Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK., Obeidat M; The University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada., Melbourne C; Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK., Shrine N; Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK., Guyatt AL; Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK., John C; Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Richmond A; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK., Moksnes MR; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Granell R; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK., Weiss S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany., Imboden M; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., May-Wilson S; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK., Hysi P; The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London, UK., Boutin TS; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK., Portas L; Population Health and Occupational Disease, National Heart and Lung Institute, Imperial College London, London, UK., Flexeder C; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Wang CA; School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Callaghan, Australia., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland.; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, 33521, Finland., Palviainen T; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, FI-00014, Finland., Foong RE; Telethon Kids Institute, Perth, Australia.; School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Perth, Australia., Keidel D; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Minelli C; Population Health and Occupational Disease, National Heart and Lung Institute, Imperial College London, London, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Bossé Y; Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada., Van den Berge M; University Medical Center Groningen, Department of Pulmonology, GRIAC Research Institute, University of Groningen, Groningen, The Netherlands., Sin DD; The University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.; Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Hao K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK., Porteous D; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XU, UK., Padmanabhan S; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Smith BH; Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK., Evans DM; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK.; Population Health Sciences Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4072, Australia., Ring S; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK.; Population Health Sciences Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK., Langhammer A; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Willer C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, USA., Ewert R; Department of Internal Medicine B, Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, 17475, Germany., Stubbe B; Department of Internal Medicine B, Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, 17475, Germany., Pirastu N; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK., Klaric L; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK., Patasova K; The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London, UK., Massimo M; The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London, UK., Polasek O; University of Split School of Medicine, Split, Croatia., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Karrasch S; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-Universität, Munich, 80336, Germany.; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, 81377, Germany., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, 81377, Germany., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Institute of Human Genetics, Klinikum rechts der Isar der TU Muenchen, Muenchen, 81675, Germany., Rudan I; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK., Rantanen T; Faculty of Sport and Health Sciences, Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland., Pietiläinen K; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, FI-00014, Finland.; Obesity Centre, Abdominal Centre, Helsinki University Hospital and University of Helsinki, Helsinki, FI-00029, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, 33521, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Hall GL; Telethon Kids Institute, Perth, Australia.; School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Perth, Australia., Sly PD; Children's Health and Environment Program, The University of Queensland, Brisbane, Australia., Pennell CE; School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Callaghan, Australia., Kaprio J; Institute for Molecular Medicine FIMM, University of Helsinki, Helsinki, FI-00014, Finland.; Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.; Psychology, University of Edinburgh, Edinburgh, EH8 9JZ, UK., Jarvis D; Population Health and Occupational Disease, National Heart and Lung Institute, Imperial College London, London, UK.; MRC-PHE Centre for the Environment and Health, London, UK., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK., Spector T; The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London, UK., Probst-Hensch N; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Völzke H; Intitute for Community Medicine, University Medicine Greifswald, Greifswald, 17487, Germany., Henderson J; Population Health Sciences Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK., Strachan DP; Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK., Brumpton BM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK., Hall IP; Division of Respiratory Medicine and NIHR-Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK., Tobin MD; Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK.; National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK., Wain LV; Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK.; National Institute for Health Research, Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK. |
| المصدر: | Wellcome open research [Wellcome Open Res] 2021 May 24; Vol. 5, pp. 111. Date of Electronic Publication: 2021 May 24 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wellcome Trust Country of Publication: England NLM ID: 101696457 Publication Model: eCollection Cited Medium: Print ISSN: 2398-502X (Print) Linking ISSN: 2398502X NLM ISO Abbreviation: Wellcome Open Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Wellcome Trust, [2016]- |
| مستخلص: | Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P<5x10 -8 ) interactions with sex on lung function, and 21 showed suggestive interactions (P<1x10 -6 ). The strongest signal, from rs7697189 (chr4:145436894) on forced expiratory volume in 1 second (FEV Competing Interests: Competing interests: The following authors report potential competing interests: L.V.W.: Louise V. Wain has received grant support from GSK. M.D.T.: Martin D. Tobin has received grant support from GSK. I.P.H.: Ian P. Hall has received support from GSK and BI. (Copyright: © 2021 Fawcett KA et al.) |
| معلومات مُعتمدة: | R01 HL109946 United States HL NHLBI NIH HHS; R01 MH062633 United States MH NIMH NIH HHS; R35 HL135824 United States HL NHLBI NIH HHS; MR/R026408/1 United Kingdom MRC_ Medical Research Council; G1000143 United Kingdom MRC_ Medical Research Council; G1001401 United Kingdom MRC_ Medical Research Council; 14136 United Kingdom CRUK_ Cancer Research UK; MR/N011317/1 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; MC_UU_12013/4 United Kingdom MRC_ Medical Research Council; MR/M022501/1 United Kingdom MRC_ Medical Research Council; MR/K026992/1 United Kingdom MRC_ Medical Research Council; MR/N003284/1 United Kingdom MRC_ Medical Research Council; G0700704 United Kingdom MRC_ Medical Research Council; R01 HL127564 United States HL NHLBI NIH HHS; MR/P00167X/1 United Kingdom MRC_ Medical Research Council; G0401527 United Kingdom MRC_ Medical Research Council; MC_PC_U127592696 United Kingdom MRC_ Medical Research Council; MC_UU_00007/10 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: HHIP; expression; genome-wide interaction study; lung function; sex |
| سلسلة جزيئية: | figshare 10.6084/m9.figshare.12298736.v1 |
| تواريخ الأحداث: | Date Created: 20210607 Latest Revision: 20230816 |
| رمز التحديث: | 20230816 |
| مُعرف محوري في PubMed: | PMC7938335.2 |
| DOI: | 10.12688/wellcomeopenres.15846.2 |
| PMID: | 33728380.2. Version: 2. Publisher Version ID: 2. Version Date: 2021/05/24 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2398-502X |
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| DOI: | 10.12688/wellcomeopenres.15846.2 |