دورية أكاديمية
Preventive activity of Copaifera langsdorffii Desf. leaves extract and its major compounds, afzelin and quercitrin, on DNA damage in in vitro and in vivo models.
| العنوان: | Preventive activity of Copaifera langsdorffii Desf. leaves extract and its major compounds, afzelin and quercitrin, on DNA damage in in vitro and in vivo models. |
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| المؤلفون: | Ozelin SD; Laboratório De Mutagênese, Universidade De Franca, Franca, São Paulo, Brazil., Senedese JM; Laboratório De Mutagênese, Universidade De Franca, Franca, São Paulo, Brazil., Alves JM; Laboratório De Mutagênese, Universidade De Franca, Franca, São Paulo, Brazil., Munari CC; Laboratório De Mutagênese, Universidade De Franca, Franca, São Paulo, Brazil., Costa JCD; Facudade De Ciências Farmacêuticas De Ribeirão Preto, Universidade De São Paulo, São Paulo, Brazil., Resende FA; Faculdade De Ciências Farmacêuticas De Araraquara, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil., Campos DL; Faculdade De Ciências Farmacêuticas De Araraquara, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil., Lima IMS; Laboratório De Mutagênese, Universidade De Franca, Franca, São Paulo, Brazil., Andrade AF; Laboratório De Mutagênese, Universidade De Franca, Franca, São Paulo, Brazil., Varanda EA; Faculdade De Ciências Farmacêuticas De Araraquara, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil., Bastos JK; Facudade De Ciências Farmacêuticas De Ribeirão Preto, Universidade De São Paulo, São Paulo, Brazil., Tavares DC; Laboratório De Mutagênese, Universidade De Franca, Franca, São Paulo, Brazil. |
| المصدر: | Journal of toxicology and environmental health. Part A [J Toxicol Environ Health A] 2021 Jul 18; Vol. 84 (14), pp. 569-581. Date of Electronic Publication: 2021 Mar 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 100960995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-7394 (Print) Linking ISSN: 00984108 NLM ISO Abbreviation: J Toxicol Environ Health A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. ; London : Taylor & Francis, c1998- |
| مواضيع طبية MeSH: | DNA Damage/*drug effects , Fabaceae/*chemistry , Mannosides/*pharmacology , Plant Extracts/*pharmacology , Proanthocyanidins/*pharmacology , Protective Agents/*pharmacology , Quercetin/*analogs & derivatives, Animals ; Doxorubicin/toxicity ; Hep G2 Cells ; Humans ; Male ; Methyl Methanesulfonate/toxicity ; Mice ; Mutagens/pharmacology ; Mutagens/toxicity ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Quercetin/pharmacology ; Salmonella typhimurium/drug effects |
| مستخلص: | Copaifera langsdorffii Desf. is a plant found in South America, especially in Brazil. Oleoresin and the leaves of this plant is used as a popular medicinal agent. However, few studies on the chemical composition of aerial parts and related biological activities are known. This study aimed to examine the cytotoxic, genotoxic, and antigenotoxic potential of C. langsdorffii aerial parts hydroalcoholic extract (CLE) and two of its major compounds afzelin and quercitrin. The cytotoxic and antigenotoxic potential of CLE was determined as follows: 1) against genotoxicity induced by doxorubicin (DXR) or methyl methanesulfonate (MMS) in V79 cells; 2) by direct and indirect-acting mutagens in Salmonella typhimurium strains; and 3) by MMS in male Swiss mice. The protective effects of afzelin and quercitrin against DXR or MMS were also evaluated in V79 and HepG2 cells. CLE was cytotoxic as evidenced by clonogenic efficiency assay. Further, CLE did not induce a significant change in frequencies of chromosomal aberrations and micronuclei; as well as number of revertants in the Ames test demonstrating absence of genotoxicity. In contrast, CLE was found to be antigenotoxic in mammalian cells. The results also showed that CLE exerted inhibitory effect against indirect-acting mutagens in the Ames test. Afzelin and quercitrin did not reduce genotoxicity induced by DXR or MMS in V79 cells. However, treatments using afzelin and quercitrin decreased MMS-induced genotoxicity in HepG2 cells. The antigenotoxic effect of CLE observed in this study may be partially attributed to the antioxidant activity of the combination of major components afzelin and quercitrin. |
| فهرسة مساهمة: | Keywords: Copaifera langsdorffii; afzelin; antigenotoxicity; genotoxicity; quercitrin |
| المشرفين على المادة: | 0 (Mannosides) 0 (Mutagens) 0 (Plant Extracts) 0 (Proanthocyanidins) 0 (Protective Agents) 2Y8906LC5P (quercitrin) 5M86W1YH7O (afzelin) 80168379AG (Doxorubicin) 9IKM0I5T1E (Quercetin) AT5C31J09G (Methyl Methanesulfonate) |
| تواريخ الأحداث: | Date Created: 20210318 Date Completed: 20210916 Latest Revision: 20210916 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/15287394.2021.1898505 |
| PMID: | 33730993 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1528-7394 |
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| DOI: | 10.1080/15287394.2021.1898505 |