دورية أكاديمية
Oral health, organic and inorganic saliva composition of men with Schizophrenia: Case-control study.
| العنوان: | Oral health, organic and inorganic saliva composition of men with Schizophrenia: Case-control study. |
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| المؤلفون: | Rosa LK; Federal University of Paraná, Department of Stomatology, Curitiba, PR, 80210-170, Brazil., Costa FS; Federal University of Paraná, Department of Chemistry, Curitiba, PR, 81531-980, Brazil., Hauagge CM; Federal University of Paraná, Department of Stomatology, Curitiba, PR, 80210-170, Brazil., Mobile RZ; Federal University of Paraná, Department of Stomatology, Curitiba, PR, 80210-170, Brazil., de Lima AAS; Federal University of Paraná, Department of Stomatology, Curitiba, PR, 80210-170, Brazil., Amaral CDB; Federal University of Paraná, Department of Chemistry, Curitiba, PR, 81531-980, Brazil., Machado RC; Federal University of São Carlos, Department of Chemistry, São Carlos, SP, 13565-905, Brazil., Nogueira ARA; Embrapa Pecuária Sudeste, São Carlos, SP, 13560-970, Brazil., Brancher JA; Pontifícia Universidade Católica do Paraná, Escola de Ciências da Vida, Curitiba, PR, 80215-901, Brazil., de Araujo MR; Federal University of Paraná, Department of Stomatology, Curitiba, PR, 80210-170, Brazil. Electronic address: melissararaujo@ufpr.br. |
| المصدر: | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2021 Jul; Vol. 66, pp. 126743. Date of Electronic Publication: 2021 Mar 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Gustav Fisher Country of Publication: Germany NLM ID: 9508274 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3252 (Electronic) Linking ISSN: 0946672X NLM ISO Abbreviation: J Trace Elem Med Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Gustav Fisher Original Publication: Stuttgart ; New York : Gustav Fischer, c1995- |
| مواضيع طبية MeSH: | Metals/*chemistry , Saliva/*chemistry , Schizophrenia/*metabolism , Trace Elements/*analysis, Adolescent ; Adult ; Aged ; Artificial Intelligence ; Case-Control Studies ; Humans ; Male ; Mass Spectrometry ; Metals/metabolism ; Middle Aged ; Oral Health ; Saliva/metabolism |
| مستخلص: | Background: Schizophrenia (SCZ) presents complex challenges related to diagnosis and clinical monitoring. The study of conditions associated with SCZ can be facilitated by using potential markers and patterns that provide information to support the diagnosis and oral health. Methods: The salivary composition of patients diagnosed with SCZ (n = 50) was evaluated and compared to the control (n = 50). Saliva samples from male patients were collected and clinical parameters were evaluated. The concentration of total proteins and amylase were determined and salivary macro- and microelements were quantified by ICP OES and ICP-MS. Exploratory data analysis based on artificial intelligence tools was used in the investigation. Results: There was a significant increase in the salivary concentrations of Al, Fe, Li, Mg, Na, and V, higher prevalence of caries (p < 0.001), periodontal disease (p < 0.001), and reduced salivary flow rate (p = 0.019) in SCZ patients. Also, samples were grouped into six clusters. As, Co, Cr, Cu, Mn, Mo, Ni, Se, and Sr were correlated with each other, while Fe, K, Li, Ti, and V showed the highest concentrations in the samples distributed in the clusters with the highest association between SZC patients and controls. Conclusions: The results obtained indicate changes in salivary flow, organic composition, and levels of macro- and microelements in SCZ patients. Salivary concentrations of Fe, Mg, and Na may be related to oral conditions, higher prevalence of caries, and periodontal disease. The exploratory analysis showed different patterns in the salivary composition of SCZ patients impacted by associations between oral health conditions and the use of medications. Future studies are encouraged to confirm the results investigated in this study. (Copyright © 2021 Elsevier GmbH. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Exploratory data analysis; Saliva; Schizophrenia; Self-organizing map; Trace elements |
| المشرفين على المادة: | 0 (Metals) 0 (Trace Elements) |
| تواريخ الأحداث: | Date Created: 20210319 Date Completed: 20211108 Latest Revision: 20211108 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jtemb.2021.126743 |
| PMID: | 33740480 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-3252 |
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| DOI: | 10.1016/j.jtemb.2021.126743 |