دورية أكاديمية
أعرض في EDS

Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.

التفاصيل البيبلوغرافية
العنوان: Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women.
المؤلفون: Ferreira LC; Department of Biochemistry, Center of Biosciences, Federal University of Rio Grande do Norte, Av. Sen. Salgado Filho, S/N, Campus Universitário - Lagoa Nova, Natal, RN, 59078-900, Brazil. ferreiralc@cb.ufrn.br.; Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, Brazil. ferreiralc@cb.ufrn.br., Gomes CEM; Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil., Duggal P; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA., De Paula Holanda I; Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, Brazil., de Lima AS; Maternidade Escola Januario Cicco, Federal University of Rio Grande do Norte, Natal, Brazil., do Nascimento PRP; Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, Brazil., Jeronimo SMB; Institute of Tropical Medicine of Rio Grande do Norte, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, Brazil.; Institute of Science and Technology of Tropical Diseases (INCT-DT), Salvador, Brazil.
المصدر: Scientific reports [Sci Rep] 2021 Mar 24; Vol. 11 (1), pp. 6764. Date of Electronic Publication: 2021 Mar 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Genetic Association Studies* , Genetic Predisposition to Disease*, Aminopeptidases/*genetics , Eclampsia/*genetics , Minor Histocompatibility Antigens/*genetics , Pre-Eclampsia/*genetics, Alleles ; Brazil/epidemiology ; Eclampsia/diagnosis ; Eclampsia/epidemiology ; Female ; Gene Frequency ; Genotype ; HELLP Syndrome/diagnosis ; HELLP Syndrome/epidemiology ; HELLP Syndrome/genetics ; Haplotypes ; Humans ; Linkage Disequilibrium ; Models, Genetic ; Odds Ratio ; Phenotype ; Population Surveillance ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/epidemiology ; Pregnancy ; Reproducibility of Results
مستخلص: The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown. ERAP1, ERAP2 and LNPEP genes code for multifunctional aminopeptidases involved with antigen processing and degradation of small peptides such as angiotensin II (Ang II), vasopressin and oxytocin. We aimed to test for associations between genetic variants in aminopeptidases and HDP. A total of 1282 pregnant women (normotensive controls, n = 693; preeclampsia, n = 342; chronic hypertension with superimposed preeclampsia, n = 61; eclampsia, n = 74; and HELLP syndrome, n = 112) were genotyped for variants in LNPEP (rs27300, rs38034, rs2303138), ERAP1 (rs27044, rs30187) and ERAP2 (rs2549796 rs2927609 rs11135484). We also evaluated the effect of ERAP1 rs30187 on plasma Ang II levels in an additional cohort of 65 pregnant women. The genotype C/C, in ERAP1 rs30187 variant (c.1583 T > C, p.Lys528Arg), was associated with increased risk of eclampsia (OR = 1.85, p = 0.019) whereas ERAP2 haplotype rs2549796(C)-rs2927609(C)-rs11135484(G) was associated with preeclampsia (OR = 1.96, corrected p-value = 0.01). Ang II plasma levels did not differ across rs30187 genotypic groups (p = 0.895). In conclusion, ERAP1 gene is associated with eclampsia whereas ERAP2 is associated with preeclampsia, although the mechanism by which genetic variants in ERAPs influence the risk of preeclampsia and eclampsia remain to be elucidated.
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المشرفين على المادة: 0 (Minor Histocompatibility Antigens)
EC 3.4.11.- (Aminopeptidases)
EC 3.4.11.- (ERAP1 protein, human)
EC 3.4.11.- (ERAP2 protein, human)
تواريخ الأحداث: Date Created: 20210325 Date Completed: 20211025 Latest Revision: 20211025
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7990956
DOI: 10.1038/s41598-021-86240-z
PMID: 33762660
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-86240-z