دورية أكاديمية
أعرض في EDS

The prevalence and demographic features of congenital cytomegalovirus infection in an urban area of East Asia: A population-based study.

التفاصيل البيبلوغرافية
العنوان: The prevalence and demographic features of congenital cytomegalovirus infection in an urban area of East Asia: A population-based study.
المؤلفون: Yang TH; Department of Otorhinolaryngology, Taipei City Hospital, Taipei, Taiwan.; Department of Speech Language Pathology and Audiology, National Taipei University of Nursing Health Sciences, Taipei, Taiwan.; General Education Center, University of Taipei, Taipei, Taiwan., Huang HM; Department of Otorhinolaryngology, Taipei City Hospital, Taipei, Taiwan.; Department of Otolaryngology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Hsu WC; Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan., Tsao PN; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan., Liu TC; Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan., Hsu CJ; Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan., Huang LM; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan., Wu CS; Department of Otorhinolaryngology, Taipei City Hospital, Taipei, Taiwan.; College of Science and Engineering, Fu Jen University, New Taipei City, Taiwan., Weng SM; Department of Speech Language Pathology and Audiology, National Taipei University of Nursing Health Sciences, Taipei, Taiwan.; Department of Pediatrics, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan., Lu CY; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan., Wu CC; Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.; Department of Medical Research, National Taiwan University Biomedical Park Hospital, Hsinchu, Taiwan.
المصدر: PloS one [PLoS One] 2021 Mar 25; Vol. 16 (3), pp. e0248801. Date of Electronic Publication: 2021 Mar 25 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Urban Population*, Cytomegalovirus Infections/*congenital , Cytomegalovirus Infections/*epidemiology, Cytomegalovirus Infections/virology ; Asia, Eastern/epidemiology ; Female ; Hearing ; Humans ; Infant, Newborn ; Neonatal Screening ; Pregnancy ; Prevalence
مستخلص: Congenital cytomegalovirus (cCMV) infection is the leading environmental cause of childhood hearing impairment. However, its significance remains largely undocumented in many regions of the world. The purpose of this study was to investigate the prevalence and clinical features of cCMV infection in East Asia. Neonates born at a municipal hospital in Taipei were prospectively recruited and underwent concurrent hearing and CMV screenings. Those who failed the hearing screening or screened positive for CMV were subjected to a focused audiological and/or virological surveillance. The characteristics of the newborns and their mothers were compared between the CMV-positive and CMV-negative groups. Of the 1,532 newborns who underwent concurrent hearing and CMV screenings, seven (0.46%) were positive for cCMV infection. All seven CMV-positive newborns were asymptomatic at birth, and none of them developed hearing or other symptoms during a follow-up period of 14.4±6.3 months. The mothers of the CMV-positive newborns demonstrated higher gravidity (2.4 ± 1.4 vs. 2.1 ± 1.2) and parity (2.0 ± 1.2 vs. 1.6 ± 0.7) than those in the CMV-negative group; however, the difference did not reach statistical significance. The prevalence of cCMV infection in Taipei newborns was 0.46%, which is slightly lower than that of other populations and that of a previous report in the Taiwanese population. The relatively low prevalence in this study might be attributed to the improved public health system and decreased fertility rate in Taiwan.
Competing Interests: The authors have declared that no competing interests exist.
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تواريخ الأحداث: Date Created: 20210325 Date Completed: 20211012 Latest Revision: 20221207
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7993615
DOI: 10.1371/journal.pone.0248801
PMID: 33765031
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0248801