دورية أكاديمية
أعرض في EDS

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis.

التفاصيل البيبلوغرافية
العنوان: Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis.
المؤلفون: Whitehead A; School of Medicine, University of Leeds, Leeds, UK., Krause FN; Department of Biochemistry, University of Cambridge, Cambridge, UK., Moran A; School of Medicine, University of Leeds, Leeds, UK., MacCannell ADV; School of Medicine, University of Leeds, Leeds, UK., Scragg JL; School of Medicine, University of Leeds, Leeds, UK., McNally BD; Department of Biochemistry, University of Cambridge, Cambridge, UK., Boateng E; School of Medicine, University of Leeds, Leeds, UK., Murfitt SA; Department of Biochemistry, University of Cambridge, Cambridge, UK., Virtue S; Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wright J; School of Medicine, University of Leeds, Leeds, UK., Garnham J; School of Medicine, University of Leeds, Leeds, UK., Davies GR; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Dodgson J; Phenotypic Screening and High Content Imaging, Antibody Discovery & Protein Engineering, R&D, AstraZeneca, Cambridge, UK., Schneider JE; School of Medicine, University of Leeds, Leeds, UK., Murray AJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Church C; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Vidal-Puig A; Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Witte KK; School of Medicine, University of Leeds, Leeds, UK., Griffin JL; Department of Biochemistry, University of Cambridge, Cambridge, UK., Roberts LD; School of Medicine, University of Leeds, Leeds, UK. L.D.Roberts@leeds.ac.uk.
المصدر: Nature communications [Nat Commun] 2021 Mar 26; Vol. 12 (1), pp. 1905. Date of Electronic Publication: 2021 Mar 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Adipose Tissue, Beige/*metabolism , Adipose Tissue, Brown/*metabolism , Energy Metabolism/*genetics , Homeostasis/*genetics , Signal Transduction/*genetics, Adipocytes, Brown/metabolism ; Adipocytes, White/metabolism ; Adipose Tissue, Beige/cytology ; Adipose Tissue, Brown/cytology ; Animals ; Cell Line ; Cells, Cultured ; Chromatography, Liquid ; Gas Chromatography-Mass Spectrometry ; Gene Expression Profiling/methods ; Humans ; Male ; Mass Spectrometry ; Metabolomics/methods ; Mice, Inbred C57BL ; Mice
مستخلص: Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid, 5-oxoproline, and β-hydroxyisobutyric acid as small molecule metabokines synthesized in browning adipocytes and secreted via monocarboxylate transporters. 3-methyl-2-oxovaleric acid, 5-oxoproline and β-hydroxyisobutyric acid induce a brown adipocyte-specific phenotype in white adipocytes and mitochondrial oxidative energy metabolism in skeletal myocytes both in vitro and in vivo. 3-methyl-2-oxovaleric acid and 5-oxoproline signal through cAMP-PKA-p38 MAPK and β-hydroxyisobutyric acid via mTOR. In humans, plasma and adipose tissue 3-methyl-2-oxovaleric acid, 5-oxoproline and β-hydroxyisobutyric acid concentrations correlate with markers of adipose browning and inversely associate with body mass index. These metabolites reduce adiposity, increase energy expenditure and improve glucose and insulin homeostasis in mouse models of obesity and diabetes. Our findings identify beige adipose-brown adipose-muscle physiological metabokine crosstalk.
References: Endocrinology. 2011 Dec;152(12):4641-51. (PMID: 21990309)
NMR Biomed. 2006 Apr;19(2):271-8. (PMID: 16541463)
Cell Metab. 2009 Feb;9(2):203-9. (PMID: 19187776)
J Clin Invest. 2013 Jan;123(1):215-23. (PMID: 23221344)
Cell Metab. 2009 Apr;9(4):311-26. (PMID: 19356713)
Cell Res. 2013 Jun;23(6):851-4. (PMID: 23649313)
Nat Chem Biol. 2018 Nov;14(11):1021-1031. (PMID: 30327559)
Diabetes. 2014 Oct;63(10):3253-65. (PMID: 24789919)
Nat Rev Endocrinol. 2014 Dec;10(12):723-36. (PMID: 25287287)
Cell Metab. 2012 May 2;15(5):606-14. (PMID: 22560213)
Trends Endocrinol Metab. 2017 Dec;28(12):855-867. (PMID: 29113711)
Endocrinology. 1996 Jan;137(1):21-9. (PMID: 8536614)
Cell Metab. 2008 May;7(5):410-20. (PMID: 18460332)
Genome Biol. 2011 Aug 11;12(8):R75. (PMID: 21843327)
Nat Med. 2016 Apr;22(4):421-6. (PMID: 26950361)
Hum Mol Genet. 2018 Oct 15;27(20):3641-3649. (PMID: 30124842)
Nature. 1993 Dec 23-30;366(6457):740-2. (PMID: 8264795)
J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):529-541. (PMID: 28493406)
Cell. 2012 Jul 20;150(2):366-76. (PMID: 22796012)
Diabetes. 2015 Feb;64(2):471-484. (PMID: 25249574)
Proc Natl Acad Sci U S A. 2014 May 27;111(21):7849-54. (PMID: 24825887)
J Inherit Metab Dis. 1993;16(4):648-69. (PMID: 8412012)
Mol Metab. 2018 Mar;9:192-198. (PMID: 29396369)
Mol Cell Biol. 2004 Apr;24(7):3057-67. (PMID: 15024092)
Cell. 1999 Jul 9;98(1):115-24. (PMID: 10412986)
PLoS Med. 2008 Mar 11;5(3):e51. (PMID: 18336063)
J Vis Exp. 2012 Apr 04;(62):e3680. (PMID: 22508524)
Cell Metab. 2018 Oct 2;28(4):656-666.e1. (PMID: 30017358)
Cell Metab. 2007 Jul;6(1):38-54. (PMID: 17618855)
Pharm Res. 2019 Apr 17;36(6):84. (PMID: 30997560)
Nature. 2019 Aug;572(7771):614-619. (PMID: 31435015)
Mol Aspects Med. 2013 Apr-Jun;34(2-3):337-49. (PMID: 23506875)
Cell Metab. 2014 Jan 7;19(1):96-108. (PMID: 24411942)
Cell Metab. 2019 Feb 5;29(2):417-429.e4. (PMID: 30449684)
J Biol Chem. 2015 Jan 23;290(4):2303-11. (PMID: 25371203)
Mol Cell Biol. 2001 Jan;21(1):319-29. (PMID: 11113206)
Cell Metab. 2013 Jul 2;18(1):43-50. (PMID: 23770128)
J Lipid Res. 1997 Oct;38(10):2125-33. (PMID: 9374134)
EMBO Rep. 2017 Dec;18(12):2172-2185. (PMID: 29066459)
Nature. 2000 Apr 6;404(6778):652-60. (PMID: 10766252)
Nucleic Acids Res. 2018 Jul 2;46(W1):W486-W494. (PMID: 29762782)
Nat Med. 2011 Apr;17(4):448-53. (PMID: 21423183)
IUBMB Life. 2012 Jan;64(1):1-9. (PMID: 22131303)
Proc Natl Acad Sci U S A. 1985 Jan;82(2):445-8. (PMID: 3855564)
J Clin Invest. 2011 Jan;121(1):96-105. (PMID: 21123942)
Diabetes. 2017 Mar;66(3):674-688. (PMID: 28028076)
J Biol Chem. 2001 Jul 20;276(29):27077-82. (PMID: 11369767)
Nat Commun. 2020 Jan 31;11(1):624. (PMID: 32005798)
J Lipid Res. 1989 Nov;30(11):1811-7. (PMID: 2614280)
Nature. 1997 May 1;387(6628):90-4. (PMID: 9139827)
Biochem J. 1999 Oct 15;343 Pt 2:281-99. (PMID: 10510291)
J Biol Chem. 2010 Apr 9;285(15):11348-56. (PMID: 20093359)
Front Physiol. 2013 Jun 04;4:128. (PMID: 23760815)
Curr Protoc Mol Biol. 2012 Apr;Chapter 30:Unit 30.2.1-24. (PMID: 22470063)
Genes Dev. 2013 Feb 1;27(3):234-50. (PMID: 23388824)
Biochem Biophys Res Commun. 2010 Sep 24;400(3):318-22. (PMID: 20727852)
Cell Metab. 2018 Oct 2;28(4):631-643.e3. (PMID: 30078553)
J Clin Invest. 2003 Feb;111(3):399-407. (PMID: 12569166)
Nat Med. 2015 Jul;21(7):760-8. (PMID: 26076036)
Diabetes. 2010 Jul;59(7):1789-93. (PMID: 20357363)
Lancet Diabetes Endocrinol. 2014 Jan;2(1):65-75. (PMID: 24622670)
Biochem Med. 1975 Nov;14(3):339-45. (PMID: 1225334)
Cell. 2003 Apr 18;113(2):159-70. (PMID: 12705865)
J Clin Invest. 2016 May 2;126(5):1704-16. (PMID: 27018708)
Cell. 2014 Jan 16;156(1-2):20-44. (PMID: 24439368)
Sci Rep. 2015 Aug 11;5:13091. (PMID: 26260892)
معلومات مُعتمدة: MC_UU_00014/2 United Kingdom MRC_ Medical Research Council; 16/0005382 United Kingdom DUK_ Diabetes UK; MC_PC_13030 United Kingdom MRC_ Medical Research Council; BB/R013500/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; MR/P011705/1 United Kingdom MRC_ Medical Research Council; BB/H013539/2 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; MC_UU_12012/2 United Kingdom MRC_ Medical Research Council; G0802051 United Kingdom MRC_ Medical Research Council; MR/R014086/1 United Kingdom MRC_ Medical Research Council; MC_UP_A090_1006 United Kingdom MRC_ Medical Research Council; G0400192 United Kingdom MRC_ Medical Research Council; MC_UU_12012/5 United Kingdom MRC_ Medical Research Council; RG/18/7/33636 United Kingdom BHF_ British Heart Foundation; MR/P01836X/1 United Kingdom MRC_ Medical Research Council; RG/12/13/29853 United Kingdom BHF_ British Heart Foundation
تواريخ الأحداث: Date Created: 20210327 Date Completed: 20210412 Latest Revision: 20240331
رمز التحديث: 20240331
مُعرف محوري في PubMed: PMC7998027
DOI: 10.1038/s41467-021-22272-3
PMID: 33772024
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-021-22272-3