دورية أكاديمية
Effect of high-density lipoprotein on penile erection: A cross-sectional study.
| العنوان: | Effect of high-density lipoprotein on penile erection: A cross-sectional study. |
|---|---|
| المؤلفون: | Xu ZH; School of Medicine, Shandong University, Jinan, China.; Department of Urology, Shandong Provincial Hospital, Jinan, China.; Department of Urology, The Second Hospital of Shandong University, Jinan, China., Xu HX; Shenzhen People's Hospital, Shenzhen, China., Jiang S; School of Medicine, Shandong University, Jinan, China.; Department of Urology, Shandong Provincial Hospital, Jinan, China., Xu QF; School of Medicine, Shandong University, Jinan, China.; Department of Urology, Shandong Provincial Hospital, Jinan, China., Ding K; School of Medicine, Shandong University, Jinan, China.; Department of Urology, Shandong Provincial Hospital, Jinan, China., Zhang DX; School of Medicine, Shandong University, Jinan, China.; Department of Urology, Shandong Provincial Hospital, Jinan, China., Guan Y; School of Medicine, Shandong University, Jinan, China.; Department of Urology, Shandong Provincial Hospital, Jinan, China., Zhao ST; School of Medicine, Shandong University, Jinan, China. |
| المصدر: | Andrologia [Andrologia] 2021 Jun; Vol. 53 (5), pp. e13979. Date of Electronic Publication: 2021 Mar 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Pub Country of Publication: Germany NLM ID: 0423506 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0272 (Electronic) Linking ISSN: 03034569 NLM ISO Abbreviation: Andrologia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: Berlin, Grosse |
| مواضيع طبية MeSH: | Erectile Dysfunction*/drug therapy , Penile Erection*, Cross-Sectional Studies ; Humans ; Lipoproteins, HDL ; Male ; Penis |
| مستخلص: | Previous studies have shown that elevated levels of high-density lipoprotein (HDL) could inhibit penile erection, but the relationship between HDL and the erection of the penile tip or base has not been extensively researched. We investigated the effects of HDL on erection of the penile tip and base through a cross-sectional study of 113 patients with erectile dysfunction, using a cut-off score of ≤21 on the International Index of Erectile Function-5. The following patient data were collected: nocturnal penile tumescence; blood pressure; platelet count; platelet distribution width; mean platelet volume; plateletcrit; and levels of serum glucose, total cholesterol, triglyceride, HDL, and low-density lipoprotein. Univariate and multivariate analyses were used to assess the association between HDL levels and the erection of the penile tip and base. We confirmed that HDL had a beneficial effect on penile erectile function. We also found that when the HDL level exceeded the normal range, the change in HDL had a significant effect on the penile base. In addition, our study did not find any relationship between platelet parameters and erection of the penile tip or penile base. (© 2021 Wiley-VCH GmbH.) |
| References: | Ayta, I. A., McKinlay, J. B., & Krane, R. J. (1999). The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU International, 84(1), 50-56. https://doi.org/10.1046/j.1464-410x.1999.00142.x. Azadzoi, K. M., & Saenz de Tejada, I. (1991). Hypercholesterolemia impairs endothelium-dependent relaxation of rabbit corpus cavernosum smooth muscle. The Journal of Urology, 146(1), 238-240. https://doi.org/10.1016/S0022-5347(17)37759-5. Besler, C., Heinrich, K., Rohrer, L., Doerries, C., Riwanto, M., Shih, D. M., Chroni, A., Yonekawa, K., Stein, S., Schaefer, N., Mueller, M., Akhmedov, A., Daniil, G., Manes, C., Templin, C., Wyss, C., Maier, W., Tanner, F. C., Matter, C. M., … Landmesser, U. (2011). Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. The Journal of Clinical Investigation, 121(7), 2693-2708. Bhagat, K., & Vallance, P. (1997). Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo. Circulation, 96(9), 3042-3047. https://doi.org/10.1161/01.CIR.96.9.3042. Blair, A., Shaul, P. W., Yuhanna, I. S., Conrad, P. A., & Smart, E. J. (1999). Oxidized low density lipoprotein displaces endothelial nitric-oxide synthase (eNOS) from plasmalemmal caveolae and impairs eNOS activation. The Journal of Biological Chemistry, 274(45), 32512-32519. https://doi.org/10.1074/jbc.274.45.32512. Burnett, A. L., Nehra, A., Breau, R. H., Culkin, D. J., Faraday, M. M., Hakim, L. S., Heidelbaugh, J., Khera, M., McVary, K. T., Miner, M. M., Nelson, C. J., Sadeghi-Nejad, H., Seftel, A. D., & Shindel, A. W. (2018). Erectile dysfunction: AUA guideline. The Journal of Urology, 200(3), 633-641. https://doi.org/10.1016/j.juro.2018.05.004. Culha, M. G., Atalay, H. A., Canat, H. L., Alkan, I., Ozbir, S. et al (2018). The relationship between erectile dysfunction severity, mean platelet volume and vitamin D levels. The Aging Male, 23, 173-178. https://doi.org/10.1080/13685538.2018.1459544. Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994). Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. The Journal of Urology, 151(1), 54-61. https://doi.org/10.1016/S0022-5347(17)34871-1. Feldman, H. A., Johannes, C. B., Derby, C. A., Kleinman, K. P., Mohr, B. A., Araujo, A. B., & McKinlay, J. B. (2000). Erectile dysfunction and coronary risk factors: Prospective results from the Massachusetts male aging study. Preventive Medicine, 30(4), 328-338. https://doi.org/10.1006/pmed.2000.0643. Feron, O., Michel, J. B., Sase, K., & Michel, T. (1998). Dynamic regulation of endothelial nitric oxide synthase: Complementary roles of dual acylation and caveolin interactions. Biochemistry, 37(1), 193-200. Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010). Development of monocytes, macrophages, and dendritic cells. Science (New York, NY), 327(5966), 656-661. Hatzichristou, D., Rosen, R. C., Derogatis, L. R., Low, W. Y., Meuleman, E. J., Sadovsky, R., & Symonds, T. (2010). Recommendations for the clinical evaluation of men and women with sexual dysfunction. The Journal of Sexual Medicine, 7(1 Pt 2), 337-348. https://doi.org/10.1111/j.1743-6109.2009.01619.x. Hessler, J. R., Robertson, A. L. Jr, & Chisolm, G. M. 3rd (1979). LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture. Atherosclerosis, 32(3), 213-229. Huang, R., Silva, R. A. G. D., Jerome, W. G., Kontush, A., Chapman, M. J., Curtiss, L. K., Hodges, T. J., & Davidson, W. S. (2011). Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma. Nature Structural & Molecular Biology, 18(4), 416-422. https://doi.org/10.1038/nsmb.2028. Irwin, G. M. (2019). Erectile dysfunction. Primary Care: Clinics in Office Practice, 46, 249-255. https://doi.org/10.1016/j.pop.2019.02.006. Kadihasanoglu, M., Karabay, E., Yucetas, U., Erkan, E., & Ozbek, E. (2018). Relation between monocyte to high-density lipoprotein cholesterol ratio and presence and severity of erectile dysfunction. Aktuelle Urologie, 49(3), 256-261. https://doi.org/10.1055/s-0042-123163. Kuvin, J. T., Rämet, M. E., Patel, A. R., Pandian, N. G., Mendelsohn, M. E., & Karas, R. H. (2002). A novel mechanism for the beneficial vascular effects of high-density lipoprotein cholesterol: Enhanced vasorelaxation and increased endothelial nitric oxide synthase expression. American Heart Journal, 144(1), 165-172. Levkau, B., Hermann, S., Theilmeier, G., van der Giet, M., Chun, J., Schober, O., & Schäfers, M. (2004). High-density lipoprotein stimulates myocardial perfusion in vivo. Circulation, 110(21), 3355-3359. https://doi.org/10.1161/01.CIR.0000147827.43912.AE. Li, X. P., Zhao, S. P., Zhang, X. Y., Liu, L., Gao, M., & Zhou, Q.-C. (2000). Protective effect of high density lipoprotein on endothelium-dependent vasodilatation. International Journal of Cardiology, 73(3), 231-236. McCabe, M. P. S. I., & Atalla, E. (2016). Definitions of sexual dysfunctions in women and men: A consensus statement from the Fourth International Consultation on Sexual Medicine 2015. The Journal of Sexual Medicine, 13, 135-143. https://doi.org/10.1016/j.jsxm.2015.12.019. Mitidieri, E., Cirino, G., d’Emmanuele di Villa Bianca, R., & Sorrentino, R. (2020). Pharmacology and perspectives in erectile dysfunction in man. Pharmacology & Therapeutics, 208, 107493. https://doi.org/10.1016/j.pharmthera.2020.107493. Muneer, A., Kalsi, J., Nazareth, I., & Arya, M. (2014). Erectile dysfunction. BMJ (Clinical Research ed), 348, g129. https://doi.org/10.1136/bmj.g129. Parthasarathy, S., Barnett, J., & Fong, L. G. (1990). High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochimica Et Biophysica Acta, 1044(2), 275-283. Pober, J. S., & Sessa, W. C. (2007). Evolving functions of endothelial cells in inflammation. Nature Reviews Immunology, 7(10), 803-815. https://doi.org/10.1038/nri2171. Rämet, M. E., Rämet, M., Lu, Q., Nickerson, M., Savolainen, M. J., Malzone, A., & Karas, R. H. (2003). High-density lipoprotein increases the abundance of eNOS protein in human vascular endothelial cells by increasing its half-life. Journal of the American College of Cardiology, 41(12), 2288-2297. https://doi.org/10.1016/S0735-1097(03)00481-9. Ren, Z. J., Ren, P. W., Yang, B., Liao, J., Liu, S. Z., Lu, D.-L., Wei, X., Liu, L.-R., & Dong, Q. (2017). Mean platelet volume, platelet distribution width and platelet count in erectile dysfunction: A systematic review and meta-analysis. Andrologia, 49(10), e12777. https://doi.org/10.1111/and.12777. Ross, R. (1999). Atherosclerosis-An inflammatory disease. The New England Journal of Medicine, 340(2), 115-126. https://doi.org/10.1056/NEJM199901143400207. Roumeguère, T., Wespes, E., Carpentier, Y., Hoffmann, P., & Schulman, C. C. (2003). Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. European Urology, 44(3), 355-359. https://doi.org/10.1016/S0302-2838(03)00306-3. Rye, K. A. (2013). High density lipoprotein structure, function, and metabolism: A new Thematic Series. Journal of Lipid Research, 54(8), 2031-2033. https://doi.org/10.1194/jlr.E041350. Silva, R. A. G. D., Huang, R., Morris, J., Fang, J., Gracheva, E. O., Ren, G., Kontush, A., Jerome, W. G., Rye, K.-A., & Davidson, W. S. (2008). Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proceedings of the National Academy of Sciences of the United States of America, 105(34), 12176-12181. https://doi.org/10.1073/pnas.0803626105. Simonsen, U., García-Sacristán, A., & Prieto, D. (2002). Penile arteries and erection. Journal of Vascular Research, 39(4), 283-303. https://doi.org/10.1159/000065541. Trepels, T., Zeiher, A. M., & Fichtlscherer, S. (2006). The endothelium and inflammation. Endothelium: Journal of Endothelial Cell Research, 13(6), 423-429. https://doi.org/10.1080/10623320601061862. Uittenbogaard, A., Shaul, P. W., Yuhanna, I. S., Blair, A., & Smart, E. J. (2000). High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae. The Journal of Biological Chemistry, 275(15), 11278-11283. https://doi.org/10.1074/jbc.275.15.11278. Wang, N., Lan, D., Chen, W., Matsuura, F., & Tall, A. R. (2004). ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America, 101(26), 9774-9779. Wei, M., Macera, C. A., Davis, D. R., Hornung, C. A., Nankin, H. R., & Blair, S. N. (1994). Total cholesterol and high density lipoprotein cholesterol as important predictors of erectile dysfunction. American Journal of Epidemiology, 140(10), 930-937. https://doi.org/10.1093/oxfordjournals.aje.a117181. Westerterp, M., Gourion-Arsiquaud, S., Murphy, A. J., Shih, A., Cremers, S., Levine, R. L., Tall, A. R., & Yvan-Charvet, L. (2012). Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell, 11(2), 195-206. Yaman, O., Tokatli, Z., Ozdiler, E., & Anafarta, K. (2004). Effect of aging on quality of nocturnal erections: Evaluation with NPTR testing. International Journal of Impotence Research, 16(2), 150-153. https://doi.org/10.1038/sj.ijir.3901199. Yuhanna, I. S., Zhu, Y., Cox, B. E., Hahner, L. D., Osborne-Lawrence, S., Lu, P., Marcel, Y. L., Anderson, R. G. W., Mendelsohn, M. E., Hobbs, H. H., & Shaul, P. W. (2001). High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nature Medicine, 7(7), 853-857. |
| معلومات مُعتمدة: | 81670625 National Nature Science Foundation of China; 81470969 National Nature Science Foundation of China; 2019SDRX-xx Rongxiang Regenerative Medicine Foundation of Shandong University |
| فهرسة مساهمة: | Keywords: HDL; RigiScan; erectile dysfunction; penile base; penile tip |
| المشرفين على المادة: | 0 (Lipoproteins, HDL) |
| تواريخ الأحداث: | Date Created: 20210328 Date Completed: 20210621 Latest Revision: 20210621 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/and.13979 |
| PMID: | 33774838 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1439-0272 |
|---|---|
| DOI: | 10.1111/and.13979 |