دورية أكاديمية
Effect of macro-calcification on the failure mechanics of intracranial aneurysmal wall tissue.
العنوان: | Effect of macro-calcification on the failure mechanics of intracranial aneurysmal wall tissue. |
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المؤلفون: | Fortunato RN; Department of Mechanical Engineering and Materials Science, University of Pittsburgh Pittsburgh, USA., Robertson AM; Department of Mechanical Engineering and Materials Science, University of Pittsburgh Pittsburgh, USA.; Department of Bioengineering, University of Pittsburgh Pittsburgh, USA., Sang C; Department of Mechanical Engineering and Materials Science, University of Pittsburgh Pittsburgh, USA., Duan X; Intelligent Automation Group, PNC Bank, University of Pittsburgh Pittsburgh, USA., Maiti S; Department of Mechanical Engineering and Materials Science, University of Pittsburgh Pittsburgh, USA.; Department of Bioengineering, University of Pittsburgh Pittsburgh, USA.; Department of Chemical and Petroleum Engineering, University of Pittsburgh Pittsburgh, USA. |
المصدر: | Experimental mechanics [Exp Mech] 2021 Jan; Vol. 61 (1), pp. 5-18. Date of Electronic Publication: 2020 Sep 25. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Society for Experimental Stress Analysis Country of Publication: United States NLM ID: 101469718 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0014-4851 (Print) Linking ISSN: 00144851 NLM ISO Abbreviation: Exp Mech Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Norwell., etc.] : Society for Experimental Stress Analysis, 1961- |
مستخلص: | Background: Calcification was recently found to be present in the majority of cerebral aneurysms, though how calcification and the presence or absence of co-localized lipid pools affect failure properties is still unknown. Objective: The primary objective is to quantify the biomechanical effect of a macro-calcification with surrounding Near-Calcification Region (NCR) of varying mechanical properties on tissue failure behavior. Methods: We utilized a structurally informed finite element model to simulate pre-failure and failure behavior of a human cerebral tissue specimen modeled as a composite containing a macro-calcification and surrounding NCR, embedded in a fiber matrix composite. Data from multiple imaging modalities was combined to quantify the collagen organization and calcification geometry. An idealized parametric model utilizing the calibrated model was used to explore the impact of NCR properties on tissue failure. Results: Compared to tissue without calcification, peak stress was reduced by 82% and 49% for low modulus (representing lipid pool) and high modulus (simulating increase in calcification size) of the NCR, respectively. Failure process strongly depended on NCR properties with lipid pools blunting the onset of complete failure. When the NCR was calcified, the sample was able to sustain larger overall stress, however the failure process was abrupt with nearly simultaneous failure of the loaded fibers. Conclusions: Failure of calcified vascular tissue is strongly influenced by the ultrastructure in the vicinity of the calcification. Computational modeling of failure in fibrous soft tissues can be used to understand how pathological changes impact the tissue failure process, with potentially important clinical implications. |
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معلومات مُعتمدة: | R01 NS097457 United States NS NINDS NIH HHS; T32 HL076124 United States HL NHLBI NIH HHS |
فهرسة مساهمة: | Keywords: Biomechanics; Experimentally Motivated; Finite Element Model; Soft Tissue; Structural Modeling; Tissue failure |
تواريخ الأحداث: | Date Created: 20210329 Latest Revision: 20230730 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7992055 |
DOI: | 10.1007/s11340-020-00657-7 |
PMID: | 33776069 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0014-4851 |
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DOI: | 10.1007/s11340-020-00657-7 |