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Transient Ischemic Attack and Hypoventilation 12 Hours After Intra-vitreal Aflibercept Injection.

التفاصيل البيبلوغرافية
العنوان: Transient Ischemic Attack and Hypoventilation 12 Hours After Intra-vitreal Aflibercept Injection.
المؤلفون: Hamadneh T; Ophthalmology Department, The Third Affiliated Hospital of Southern Medical University, Guangzhou, CHN.; Ophthalmology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Shehadeh M; Department of Ophthalmology, Faculty of Medicine and Health Sciences, An-Najah National University Hospital, An-Najah National University, Nablus, PSE., Yasin A; Department of Ophthalmology, Faculty of Medicine and Health Sciences, An-Najah National University Hospital, An-Najah National University, Nablus, PSE., Akkawi M; Department of Ophthalmology, Faculty of Medicine and Health Sciences, An-Najah National University Hospital, An-Najah National University, Nablus, PSE., An M; Ophthalmology Department, The Third Affiliated Hospital of Southern Medical University, Guangzhou, CHN., Yamin H; Department of Internal Medicine, Faculty of Medicine and Health Sciences, An-Najah National University Hospital, An-Najah National University, Nablus, PSE., Azamtta M; Department of Internal Medicine, Faculty of Medicine and Health Sciences, An-Najah National University Hospital, An-Najah National University, Nablus, PSE.
المصدر: Cureus [Cureus] 2021 Feb 22; Vol. 13 (2), pp. e13488. Date of Electronic Publication: 2021 Feb 22.
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: Electronic Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Given the role the vascular endothelial growth factor (VEGF) plays in controlling and preserving the integrity of the vascular endothelium intravitreal administration of anti-VEGF agents may affect the risk of thromboembolic events. This is particularly noticeable in patients who are at risk for atherosclerosis. Here, we present one of the first case reports of transient ischemic attack (TIA) together with hypoventilation secondary to aflibercept injection. A 63-year-old female suffered TIA together with hypoventilation about 12 hours after the third administration of intravitreal aflibercept, which is a VEGF inhibitor for diabetic macular edema (DME). Upon presentation, she was confused, had right-sided weakness and her respiratory rate was six breaths per minute, all of these resolved within the next 24 hours. The serum tests, cerebrospinal fluid (CSF) analysis, brain imaging, and carotid Doppler ultrasound were unremarkable. An ophthalmic exam revealed signs of bilateral proliferative diabetic retinopathy with left macular edema. Detailed reports of similar cases are lacking in the literature. Hypoventilation and thromboembolic could be possible side effects of aflibercept that necessitate more investigation.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2021, Hamadneh et al.)
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فهرسة مساهمة: Keywords: aflibercept; hypoventilation; transient ischemic attack; vegf inhibitors
تواريخ الأحداث: Date Created: 20210329 Latest Revision: 20210330
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7990083
DOI: 10.7759/cureus.13488
PMID: 33777575
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.13488