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Elucidating the role of hypoxia/reoxygenation in hippocampus-dependent memory impairment: do SK channels play role?

التفاصيل البيبلوغرافية
العنوان: Elucidating the role of hypoxia/reoxygenation in hippocampus-dependent memory impairment: do SK channels play role?
المؤلفون: Kadam M; Neurobiology Division, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Developmental Organization (DRDO), Lucknow Road, Timarpur, Delhi, 110054, India., Perveen S; Neurobiology Division, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Developmental Organization (DRDO), Lucknow Road, Timarpur, Delhi, 110054, India., Kushwah N; Neurobiology Division, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Developmental Organization (DRDO), Lucknow Road, Timarpur, Delhi, 110054, India., Prasad D; Neurobiology Division, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Developmental Organization (DRDO), Lucknow Road, Timarpur, Delhi, 110054, India., Panjwani U; Neurobiology Division, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Developmental Organization (DRDO), Lucknow Road, Timarpur, Delhi, 110054, India., Kumar B; Neurobiology Division, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Developmental Organization (DRDO), Lucknow Road, Timarpur, Delhi, 110054, India., Khan N; Neurobiology Division, Defence Institute of Physiology and Allied Sciences (DIPAS), Defence Research and Developmental Organization (DRDO), Lucknow Road, Timarpur, Delhi, 110054, India. nilofarkhan2003@yahoo.com.
المصدر: Experimental brain research [Exp Brain Res] 2021 Jun; Vol. 239 (6), pp. 1747-1763. Date of Electronic Publication: 2021 Mar 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0043312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1106 (Electronic) Linking ISSN: 00144819 NLM ISO Abbreviation: Exp Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer Verlag
مواضيع طبية MeSH: Hippocampus* , Memory Disorders*/etiology, Animals ; Hypoxia ; Rats ; Rats, Sprague-Dawley ; Spatial Memory
مستخلص: Professionals and mountaineers often face the problem of reperfusion injury due to re-oxygenation, upon their return to sea-level after sojourn at high altitude. Small conductance calcium-activated potassium channels (SK channels) have a role in regulating hippocampal synaptic plasticity. However, the role of SK channels under hypoxia-reoxygenation (H/R) is unknown. The present study hypothesized that SK channels play a significant role in H/R induced cognitive dysfunction. Sprague-Dawley rats were exposed to simulated HH (25,000 ft) continuously for 7 days followed by reoxygenation periods 3, 6, 24, 48, 72 and 120 h. It was observed that H/R exposure caused impairment in spatial memory as indicated by increased latency (p < 0.001) and pathlength (p < 0.001). The SK1 channel expression increased upon HH exposure (102.89 ± 7.055), which abrogated upon reoxygenation. HH exposure results in an increase in SK2 (CA3, 297.67 ± 6.69) and SK3 (CA1, 246 ± 5.13) channels which continued to increase gradually upon reoxygenation. The number of pyknotic cells (24 ± 2.03) (p < 0.01) and the expression of caspase-3 increased with HH exposure, which continued in the reoxygenation group (177.795 ± 1.264). Similar pattern was observed in lipid peroxidation (p < 0.001), LDH activity (p < 0.001) and ROS production (p < 0.001). A positive correlation of memory, cell death and oxidative stress indicates that H/R exposure increases oxidative stress coupled with SK channel expression, which may play a role in H/R-induced cognitive decline and neurodegeneration.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة: DIP-263 Defence Research and Development Organisation
فهرسة مساهمة: Keywords: Cognition; Morris water maze; Neurodegeneration; SK channels; Sprague–Dawley rats
تواريخ الأحداث: Date Created: 20210329 Date Completed: 20210728 Latest Revision: 20210728
رمز التحديث: 20240628
DOI: 10.1007/s00221-021-06095-8
PMID: 33779792
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1106
DOI:10.1007/s00221-021-06095-8