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HDAC inhibition prevents hypobaric hypoxia-induced spatial memory impairment through PΙ3K/GSK3β/CREB pathway.

التفاصيل البيبلوغرافية
العنوان: HDAC inhibition prevents hypobaric hypoxia-induced spatial memory impairment through PΙ3K/GSK3β/CREB pathway.
المؤلفون: Kumar R; Neurobiology Division, Defence Institute of Physiology and Allied Science (DIPAS), DRDO, Timarpur, New Delhi, India., Jain V; Neurophysiology Division, Defence Institute of Physiology and Allied Science (DIPAS), DRDO, Timarpur, New Delhi, India., Kushwah N; Neurobiology Division, Defence Institute of Physiology and Allied Science (DIPAS), DRDO, Timarpur, New Delhi, India., Dheer A; Neurobiology Division, Defence Institute of Physiology and Allied Science (DIPAS), DRDO, Timarpur, New Delhi, India., Mishra KP; Defence Research and Development Organisation (DRDO)-HQ, New Delhi, India., Prasad D; Neurobiology Division, Defence Institute of Physiology and Allied Science (DIPAS), DRDO, Timarpur, New Delhi, India., Singh SB; National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.
المصدر: Journal of cellular physiology [J Cell Physiol] 2021 Sep; Vol. 236 (9), pp. 6754-6771. Date of Electronic Publication: 2021 Mar 31.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4652 (Electronic) Linking ISSN: 00219541 NLM ISO Abbreviation: J Cell Physiol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Wiley-Liss
Original Publication: Philadelphia, Wistar Institute of Anatomy and Biology.
مواضيع طبية MeSH: Signal Transduction*/drug effects , Spatial Memory*/drug effects, Cyclic AMP Response Element-Binding Protein/*metabolism , Glycogen Synthase Kinase 3 beta/*metabolism , Histone Deacetylase Inhibitors/*pharmacology , Hypoxia/*complications , Memory Disorders/*etiology , Phosphatidylinositol 3-Kinases/*metabolism, Acetylation/drug effects ; Animals ; Brain-Derived Neurotrophic Factor/genetics ; Hippocampus/metabolism ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Histones/metabolism ; Male ; Memory Disorders/metabolism ; Models, Biological ; Nerve Degeneration/complications ; Neurons/drug effects ; Neurons/metabolism ; Neuroprotection/drug effects ; Promoter Regions, Genetic/genetics ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Rats
مستخلص: Hypobaric hypoxia at higher altitudes usually impairs cognitive function. Previous studies suggested that epigenetic modifications are the culprits for this condition. Here, we set out to determine how hypobaric hypoxia mediates epigenetic modifications and how this condition worsens neurodegeneration and memory loss in rats. In the current study, different duration of hypobaric hypoxia exposure showed a discrete pattern of histone acetyltransferases and histone deacetylases (HDACs) gene expression in the hippocampus when compared with control rat brains. The level of acetylation sites in histone H2A, H3 and H4 was significantly decreased under hypobaric hypoxia exposure compared to the control rat's hippocampus. Additionally, inhibiting the HDAC family with sodium butyrate administration (1.2 g/kg body weight) attenuated neurodegeneration and memory loss in hypobaric hypoxia-exposed rats. Moreover, histone acetylation increased at the promoter regions of brain-derived neurotrophic factor (BDNF); thereby its protein expression was enhanced significantly in hypobaric hypoxia exposed rats treated with HDAC inhibitor compared with hypoxic rats. Thus, BDNF expression upregulated cAMP-response element binding protein (CREB) phosphorylation by stimulation of PI3K/GSK3β/CREB axis, which counteracts hypobaric hypoxia-induced spatial memory impairment. In conclusion, these results suggested that sodium butyrate is a novel therapeutic agent for the treatment of spatial memory loss associated with hypobaric hypoxia, and also further studies are warranted to explore specific HDAC inhibitors in this condition.
(© 2021 Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: brain-derived neurotrophic factor; histone acetyl transferases; histone deacetylase; hypobaric hypoxia
المشرفين على المادة: 0 (Brain-Derived Neurotrophic Factor)
0 (Cyclic AMP Response Element-Binding Protein)
0 (Histone Deacetylase Inhibitors)
0 (Histones)
0 (RNA, Messenger)
EC 2.3.1.48 (Histone Acetyltransferases)
EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
EC 3.5.1.98 (Histone Deacetylases)
تواريخ الأحداث: Date Created: 20210331 Date Completed: 20211110 Latest Revision: 20240226
رمز التحديث: 20240226
DOI: 10.1002/jcp.30337
PMID: 33788269
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4652
DOI:10.1002/jcp.30337