دورية أكاديمية
أعرض في EDS

Pediatric multisystem SARS COV2 with versus without cardiac involvement: a multicenter study from Latin America.

التفاصيل البيبلوغرافية
العنوان: Pediatric multisystem SARS COV2 with versus without cardiac involvement: a multicenter study from Latin America.
المؤلفون: Pignatelli R; Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, 6651 Main St Legacy Tower 20th Floor, Houston, TX, 77030, USA., Antona CV; Instituto Nacional de Cardiología Ignacio Chavez, Ciudad de México, México., Rivera IR; Universidad Federal de Alagoas, Maceio, Brazil., Zenteno PA; Hospital Dr. Roberto del Río, Santiago, Chile., Acosta YT; CEDIMAT, Santo Domingo, Dominican Republic., Huertas-Quiñones M; Fundación Cardioinfantil Cardiology Institute, Bogota, Colombia., Murillo CA; Instituto Nacional de Salud del Niño San Borja, Lima, Perú., Torres FM; Instituto Nacional de Salud del Niño San Borja, Lima, Perú., Cabalin CF; Clinica Santa María, Santiago, Chile., Camacho AG; Hospital Militar de Especialidades, Ciudad de México, México., Pérez AA; Complejo Asistencial Dr. Sótero del Río, Santiago, Chile., Lombardi AB; Universidad Federal do Rio Grande do Norte, Natal, Brazil., Soares AM; Hospital Evangélico de Cachoeiro de Itapemirim, Cachoeiro de Itapemirim, Brazil., Garcia CT; Centro Policlinico Olaya, Bogotá, Colombia., Borges CT; Hospital São Camilo Cura Dar's, Fortaleza, Brazil., Villalba CN; Hospital Británico, Buenos Aires, Argentina., Lechado CR; Hospital Solidaridad, Managua, Nicaragua., Dias DT; Real Hospital Português de Beneficência, Recife, Brazil., Morales DA; Hospital Dr. Luis Calvo Mackenna, Santiago, Chile., Copete EM; Clínica La Colina, Bogotá, Colombia., Goldenberg GL; Pontificia Universidad Católica de Chile, Santiago, Chile., Salazar JS; Hospital de Especialidades, Portoviejo, Ecuador., Moreira JA; Hospital de Especialidades, Portoviejo, Ecuador., Asakura J; Hospital UNIMED, Maceio, Brazil., Sabando KS; Hospital de Especialidades, Portoviejo, Ecuador., Branco KC; Universidade Federal do Ceará, Fortaleza, Brazil., Rosas LT; Complejo Asistencial Dr. Sótero del Río, Santiago, Chile., Duarte MP; Hospital Geral do Estado de Alagoas, Maceio, Brazil., Carbajal MJ; Centro Médico ABC, Ciudad de México, México., Hernandez MR; Hospital Central Dr. Ignacio Morones, San Luis Potosí, México., Martínez MM; Centro Pediátrico del Corazón ABC-Kardias, Ciudad de México, México., Echeverría NG; Hospital General Pediatrico Acosta Ñu, Asunción, Paraguay., Caneva OM; Clínica General del Norte, Barranquilla, Colombia., Sepulveda PR; CEDIMAT, San Cristobal, Dominican Republic., Díaz PA; Hospital Dr. Luis Calvo Mackenna, Santiago, Chile., Plúas RR; Omnihospital, Guayaquil, Ecuador., Alvarado TC; IMSS Hospital de Cardiología No. 34, Monterrey, México., Faundes LT; Departamento de Pediatria Norte, Facultad de Medicina, Universidad de Chile, Santiago, Chile., Diaz YB; Hospital Dr. Luis Calvo Mackenna, Santiago, Chile., Zachariah JP; Section of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, 6651 Main St Legacy Tower 20th Floor, Houston, TX, 77030, USA. justin.zachariah@bcm.edu.
المصدر: European journal of pediatrics [Eur J Pediatr] 2021 Sep; Vol. 180 (9), pp. 2879-2888. Date of Electronic Publication: 2021 Apr 01.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7603873 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1076 (Electronic) Linking ISSN: 03406199 NLM ISO Abbreviation: Eur J Pediatr Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer Verlag
Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: COVID-19* , SARS-CoV-2*, Adolescent ; Arrhythmias, Cardiac ; Child ; Child, Preschool ; Critical Care ; Female ; Humans ; Infant ; Infant, Newborn ; Latin America/epidemiology ; Male
مستخلص: Latin America (LATAM) children offer special insight into Severe Acute Respiratory Syndrome Coronavirus 2 (SARS COV2) due to high-risk race/ethnicity, variability in medical resources, diverse socioeconomic background, and numerous involved organ systems. This multinational study of LATAM youth examined the distinguishing features of acute or late multisystem SARS COV2 with versus without cardiac involvement. A consecutive sample of youth 0-18 years old (N = 98;50% male) presenting with multisystem SARS COV2 to 32 centers in 10 Latin American countries participating in a pediatric cardiac multi-imaging society were grouped as with versus without cardiac involvement, defined as abnormal echocardiographic findings or arrhythmia. Collected clinical data were analyzed by Student's t-test or Fisher's exact test. Cardiac (N = 48, 50% male) versus no cardiac (N = 50, 50% male) were similar in age; weight; nonrespiratory symptoms; and medical history. The cardiac group had 1 death and symptoms including coronary artery dilation, ejection fraction <50%, pericardial effusion, peripheral edema, arrhythmia, and pulmonary artery thrombus. The cardiac group had higher risk of ICU admission (77% vs 54%, p = 0.02); invasive ventilation (23% vs 4%,p = 0.007); vasoactive infusions (27% vs 4%, p = 0.002); prominent respiratory symptoms (60% vs 36%, p < 0.03); abnormal chest imaging (69% vs 34%, p = 0.001); troponin (33% vs 12%, p = 0.01); alanine aminotransferase (33% vs 12%, p = 0.02); and thrombocytopenia (46% vs 22%, p = 0.02). Receiver operating curve analysis showed that abnormal laboratories had 94% sensitivity and 98% negative predictive value on the need for ICU interventions.Conclusion: In LATAM children with multisystem SARS COV2, cardiac involvement was prevalent. Cardiac involvement was more likely to require ICU interventions, certain abnormal labs, and respiratory involvement. What is Known: • SARS COV2 can be asymptomatic in children but in some cases can have serious multisystemic involvement. • Hispanic ethnicity is purportedly at high risk of SARS COV2 in nations where they are often disadvantaged minority populations. What is New: • Latin American children presenting with multisystem SARS COV2 frequently have cardiac involvement which was associated with ICU interventions; prominent respiratory symptoms; abnormal chest X-ray; elevated troponin, ALT, and thrombocytopenia. • Elevated troponin, ALT or thrombocytopenia had high sensitivity and negative predictive value on the need for intensive care interventions.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة: R01 HL148217 United States HL NHLBI NIH HHS; r01 hl148217 United States HL NHLBI NIH HHS; r01 hl148217 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: Coronary aneurysm; Myocarditis; Pediatric cardiology; SARS COV2
تواريخ الأحداث: Date Created: 20210401 Date Completed: 20210810 Latest Revision: 20210810
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8012155
DOI: 10.1007/s00431-021-04052-9
PMID: 33791862
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1076
DOI:10.1007/s00431-021-04052-9