دورية أكاديمية
Detecting Effect of Levodopa in Parkinson's Disease Patients Using Sustained Phonemes.
| العنوان: | Detecting Effect of Levodopa in Parkinson's Disease Patients Using Sustained Phonemes. |
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| المؤلفون: | Pah ND; Electrical Engineering DepartmentUniversitas SurabayaSurabaya60293Indonesia.; School of EngineeringRMIT UniversityMelbourneVIC3000Australia., Motin MA; School of EngineeringRMIT UniversityMelbourneVIC3000Australia.; Department of Electrical and Electronic EngineeringRajshahi University of Engineering and TechnologyRajshahi6204Bangladesh., Kempster P; Monash HealthClaytonVIC3168Australia., Kumar DK; School of EngineeringRMIT UniversityMelbourneVIC3000Australia. |
| المصدر: | IEEE journal of translational engineering in health and medicine [IEEE J Transl Eng Health Med] 2021 Mar 17; Vol. 9, pp. 4900409. Date of Electronic Publication: 2021 Mar 17 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 101623153 Publication Model: eCollection Cited Medium: Internet ISSN: 2168-2372 (Electronic) Linking ISSN: 21682372 NLM ISO Abbreviation: IEEE J Transl Eng Health Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Institute of Electrical and Electronics Engineers, 2013- |
| مواضيع طبية MeSH: | Neurodegenerative Diseases* , Parkinson Disease*/drug therapy , Voice*, Humans ; Levodopa/therapeutic use ; Speech |
| مستخلص: | Background: Parkinson's disease (PD) is a multi-symptom neurodegenerative disease generally managed with medications, of which levodopa is the most effective. Determining the dosage of levodopa requires regular meetings where motor function can be observed. Speech impairment is an early symptom in PD and has been proposed for early detection and monitoring of the disease. However, findings from previous research on the effect of levodopa on speech have not shown a consistent picture. Method: This study has investigated the effect of medication on PD patients for three sustained phonemes; /a/, /o/, and /m/, which were recorded from 24 PD patients during medication off and on stages, and from 22 healthy participants. The differences were statistically investigated, and the features were classified using Support Vector Machine (SVM). Results: The results show that medication has a significant effect on the change of time and amplitude perturbation (jitter and shimmer) and harmonics of /m/, which was the most sensitive individual phoneme to the levodopa response. /m/ and /o/ performed at a comparable level in discriminating PD- off from control recordings. However, SVM classifications based on the combined use of the three phonemes /a/, /o/, and /m/ showed the best classifications, both for medication effect and for separating PD from control voice. The SVM classification for PD- off versus PD- on achieved an AUC of 0.81. Conclusion: Studies of phonation by computerized voice analysis in PD should employ recordings of multiple phonemes. Our findings are potentially relevant in research to identify early parkinsonian dysarthria, and to tele-monitoring of the levodopa response in patients with established PD. |
| References: | IEEE J Biomed Health Inform. 2013 Jul;17(4):828-34. (PMID: 25055311) Biosensors (Basel). 2019 Dec 20;10(1):. (PMID: 31861890) Brain. 2010 Jun;133(Pt 6):1755-62. (PMID: 20371510) J Acoust Soc Am. 2013 Sep;134(3):2171-81. (PMID: 23967947) IEEE Trans Biomed Eng. 2010 Apr;57(4):884-93. (PMID: 19932995) J Commun Disord. 2002 May-Jun;35(3):217-39. (PMID: 12064785) Brain. 2000 Nov;123 ( Pt 11):2297-305. (PMID: 11050029) Sleep Med. 2016 Mar;19:141-7. (PMID: 26459688) Int J Telemed Appl. 2016;2016:6837498. (PMID: 27190506) J Neurol. 2021 Jun;268(6):2099-2108. (PMID: 31802219) Mov Disord. 2018 Feb;33(2):208-218. (PMID: 29168899) J Acoust Soc Am. 2011 Jan;129(1):350-67. (PMID: 21303016) Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S52-5. (PMID: 26363673) Mov Disord. 2010 Nov 15;25(15):2649-53. (PMID: 21069833) Lancet Neurol. 2006 Jun;5(6):525-35. (PMID: 16713924) Mov Disord. 2008 Mar 15;23(4):574-80. (PMID: 18163453) J Neurol. 2019 Jun;266(6):1376-1382. (PMID: 30877380) J Neural Transm (Vienna). 2016 Apr;123(4):379-87. (PMID: 26843071) Nat Rev Dis Primers. 2017 Mar 23;3:17013. (PMID: 28332488) J Speech Lang Hear Res. 1999 Jun;42(3):592-603. (PMID: 10391625) J Neural Transm (Vienna). 2017 Mar;124(3):303-334. (PMID: 28101650) IEEE J Transl Eng Health Med. 2019 Oct 07;7:2000410. (PMID: 32166050) Parkinsons Dis. 2016;2016:1941034. (PMID: 27213080) Mov Disord. 2008 Nov 15;23(15):2129-70. (PMID: 19025984) PLoS One. 2017 Oct 5;12(10):e0185613. (PMID: 28982171) J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4. (PMID: 1564476) J Commun Disord. 2018 Nov - Dec;76:1-10. (PMID: 30053648) Clin Neuropharmacol. 2001 Mar-Apr;24(2):99-102. (PMID: 11307045) Int J Speech Lang Pathol. 2010 Oct;12(5):405-13. (PMID: 20602581) J Neural Transm (Vienna). 2015 Aug;122(8):1135-42. (PMID: 25583417) J Neural Transm (Vienna). 2010 Feb;117(2):197-205. (PMID: 20012657) Mov Disord. 2016 Nov;31(11):1602-1609. (PMID: 27430479) Int Psychogeriatr. 2011 Dec;23(10):1582-91. (PMID: 21801472) Arq Neuropsiquiatr. 2010 Oct;68(5):706-11. (PMID: 21049179) Brain. 2004 Aug;127(Pt 8):1693-705. (PMID: 15215212) Front Neurol. 2018 May 17;9:260. (PMID: 29867708) Front Neurol. 2017 Aug 22;8:432. (PMID: 28878734) Brain. 2012 Apr;135(Pt 4):1141-53. (PMID: 22396397) |
| فهرسة مساهمة: | Keywords: Dysarthria; Parkinson’s disease; drug response; sustained phonemes; voice analysis |
| المشرفين على المادة: | 46627O600J (Levodopa) |
| تواريخ الأحداث: | Date Created: 20210402 Date Completed: 20211210 Latest Revision: 20240331 |
| رمز التحديث: | 20240331 |
| مُعرف محوري في PubMed: | PMC8007086 |
| DOI: | 10.1109/JTEHM.2021.3066800 |
| PMID: | 33796418 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2168-2372 |
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| DOI: | 10.1109/JTEHM.2021.3066800 |