دورية أكاديمية
أعرض في EDS

Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.

التفاصيل البيبلوغرافية
العنوان: Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil.
المؤلفون: Fintelman-Rodrigues N, da Silva APD, Dos Santos MC, Saraiva FB, Ferreira MA, Gesto J, Rodrigues DAS, Vale AM, de Azevedo IG, Soares VC, Jiang H, Tan H, Tschoeke DA, Sacramento CQ, Bozza FA, Morel CM, Bozza PT, Souza TML
المصدر: Emerging infectious diseases [Emerg Infect Dis] 2021 May; Vol. 27 (5), pp. 1446-1453. Date of Electronic Publication: 2021 Apr 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
مواضيع طبية MeSH: COVID-19* , SARS-CoV-2*, Brazil/epidemiology ; Humans ; Immunity, Humoral ; Reinfection
مستخلص: The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.
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فهرسة مساهمة: Keywords: Brazil; COVID-19; SARS-CoV-2; coronavirus disease; humoral response; next-generation sequencing; reinfection; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses
تواريخ الأحداث: Date Created: 20210402 Date Completed: 20210618 Latest Revision: 20210618
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8084520
DOI: 10.3201/eid2705.204912
PMID: 33797393
قاعدة البيانات: MEDLINE
الوصف
تدمد:1080-6059
DOI:10.3201/eid2705.204912