دورية أكاديمية
Performance of two prognostic scores that incorporate genetic information to predict long-term outcomes following resection of colorectal cancer liver metastases: An external validation of the MD Anderson and JHH-MSK scores.
| العنوان: | Performance of two prognostic scores that incorporate genetic information to predict long-term outcomes following resection of colorectal cancer liver metastases: An external validation of the MD Anderson and JHH-MSK scores. |
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| المؤلفون: | Sasaki K; Department of Surgery, Cleveland Clinic, Cleveland, OH, USA., Gagnière J; Service de Chirurgie Digestive, CHU Clermont-Ferrand, Inserm, Université Clermont Auvergne, Clermont-Ferrand, France., Dupré A; Service de Chirurgie Digestive, CHU Clermont-Ferrand, Inserm, Université Clermont Auvergne, Clermont-Ferrand, France., Ardiles V; HPB Surgery and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., O'Connor JM; Alexander Fleming Institute, Buenos Aires, Argentina., Wang J; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Moro A; Department of Surgery, Cleveland Clinic, Cleveland, OH, USA., Morioka D; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Buettner S; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Gau L; Service de Chirurgie Digestive, CHU Clermont-Ferrand, Inserm, Université Clermont Auvergne, Clermont-Ferrand, France., Ribeiro M; Service de Chirurgie Digestive, CHU Clermont-Ferrand, Inserm, Université Clermont Auvergne, Clermont-Ferrand, France., Wagner D; Department of General Surgery, Medical University of Graz, Graz, Austria., Andreatos N; Department of Surgery, Cleveland Clinic, Cleveland, OH, USA., Løes IM; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Oncology, Haukeland University Hospital, Bergen, Norway., Fitschek F; Department of General Surgery, Medical University of Vienna, Vienna, Austria., Kaczirek K; Department of General Surgery, Medical University of Vienna, Vienna, Austria., Lønning PE; Department of Clinical Science, University of Bergen, Bergen, Norway.; Department of Oncology, Haukeland University Hospital, Bergen, Norway., Kornprat P; Department of General Surgery, Medical University of Graz, Graz, Austria., Poultsides G; Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA., Kamphues C; Department of General, Visceral and Vascular Surgery, Charite Campus Benjamin Franklin, Berlin, Germany., Imai K; Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan., Baba H; Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan., Endo I; Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Kwon CHD; Department of Surgery, Cleveland Clinic, Cleveland, OH, USA., Aucejo FN; Department of Surgery, Cleveland Clinic, Cleveland, OH, USA., de Santibañes E; HPB Surgery and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Kreis ME; Department of General, Visceral and Vascular Surgery, Charite Campus Benjamin Franklin, Berlin, Germany., Margonis GA; Department of General, Visceral and Vascular Surgery, Charite Campus Benjamin Franklin, Berlin, Germany.; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. |
| المصدر: | Journal of hepato-biliary-pancreatic sciences [J Hepatobiliary Pancreat Sci] 2021 Jul; Vol. 28 (7), pp. 581-592. Date of Electronic Publication: 2021 Apr 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Japan Country of Publication: Japan NLM ID: 101528587 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-6982 (Electronic) Linking ISSN: 18686974 NLM ISO Abbreviation: J Hepatobiliary Pancreat Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Tokyo : Wiley Japan Original Publication: Tokyo : Springer Japan |
| مواضيع طبية MeSH: | Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/surgery , Liver Neoplasms*/genetics , Liver Neoplasms*/surgery, Hepatectomy ; Humans ; Prognosis ; Retrospective Studies |
| مستخلص: | Introduction: Two novel clinical risk scores (CRS) that incorporate KRAS mutation status were developed: modified CRS (mCRS) and GAME score. However, they have not been tested in large national and international cohorts. The aim of this study was to validate the prognostic discrimination utility and determine the clinical usefulness of the two novel CRS. Methods: Patients undergoing hepatectomy for CRLM (2000-2018) in 10 centers were included. The discriminatory abilities of mCRS, GAME, and Fong CRS were evaluated using Harrell's C-index and Akaike's Information Criterion. Results: In the entire cohort, the C-index of the GAME score (0.61) was significantly higher than those of Fong score (0.57) and mCRS (0.54), while the C-Index of mCRS was significantly lower than that of Fong score. When we compared the models in the various geographical regions, the C-index of GAME score was significantly higher than that of mCRS in North America, Europe, and South America. The AIC of Fong score, mCRS, and GAME score were 14 405, 14 447, and 14 319, respectively. Conclusion: In conclusion, using the largest and most heterogenous population of CRLM patients with known KRAS status, this independent, external validation demonstrated that the GAME score outperforms both the traditional Fong score and mCRS. (© 2021 Japanese Society of Hepato-Biliary-Pancreatic Surgery.) |
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| فهرسة مساهمة: | Keywords: KRAS; clinical risk score; colorectal liver metastases; hepatectomy; long-term outcome |
| تواريخ الأحداث: | Date Created: 20210402 Date Completed: 20211015 Latest Revision: 20211015 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/jhbp.963 |
| PMID: | 33797866 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1868-6982 |
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| DOI: | 10.1002/jhbp.963 |