دورية أكاديمية
أعرض في EDS

Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles.

التفاصيل البيبلوغرافية
العنوان: Cardioinotropic Effects in Subchronic Intoxication of Rats with Lead and/or Cadmium Oxide Nanoparticles.
المؤلفون: Klinova SV; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia., Katsnelson BA; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia., Minigalieva IA; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia., Gerzen OP; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia., Balakin AA; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia., Lisin RV; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia., Butova KA; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia., Nabiev SR; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia., Lookin ON; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia., Katsnelson LB; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia., Privalova LI; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia., Kuznetsov DA; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia., Shur VY; School of Natural Sciences and Mathematics, The Ural Federal University, 620002 Ekaterinburg, Russia., Shishkina EV; School of Natural Sciences and Mathematics, The Ural Federal University, 620002 Ekaterinburg, Russia., Makeev OH; The Central Research Laboratory, The Ural State Medical University, 620014 Yekaterinburg, Russia., Valamina IE; The Central Research Laboratory, The Ural State Medical University, 620014 Yekaterinburg, Russia., Panov VG; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia.; Institute of Industrial Ecology, The Urals Branch of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia., Sutunkova MP; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia., Nikitina LV; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia., Protsenko YL; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Mar 27; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Cadmium Compounds/*toxicity , Heart/*drug effects , Lead/*toxicity , Metal Nanoparticles/*toxicity , Nanotechnology/*methods , Oxides/*toxicity , Papillary Muscles/*drug effects, Animals ; Cardiotoxicity ; DNA Fragmentation ; Injections, Intraperitoneal ; Male ; Myocardium/metabolism ; Myocardium/pathology ; Myosin Heavy Chains ; Myosins/chemistry ; Protein Isoforms ; Rats ; Toxicity Tests, Subchronic
مستخلص: Subchronic intoxication was induced in outbred male rats by repeated intraperitoneal injections with lead oxide (PbO) and/or cadmium oxide (CdO) nanoparticles (NPs) 3 times a week during 6 weeks for the purpose of examining its effects on the contractile characteristics of isolated right ventricle trabeculae and papillary muscles in isometric and afterload contractions. Isolated and combined intoxication with these NPs was observed to reduce the mechanical work produced by both types of myocardial preparation. Using the in vitro motility assay, we showed that the sliding velocity of regulated thin filaments drops under both isolated and combined intoxication with CdO-NP and PbO-NP. These results correlate with a shift in the expression of myosin heavy chain (MHC) isoforms towards slowly cycling β-MHC. The type of CdO-NP + PbO-NP combined cardiotoxicity depends on the effect of the toxic impact, the extent of this effect, the ratio of toxicant doses, and the degree of stretching of cardiomyocytes and muscle type studied. Some indices of combined Pb-NP and CdO-NP cardiotoxicity and general toxicity (genotoxicity included) became fully or partly normalized if intoxication developed against background administration of a bioprotective complex.
References: Nature. 1970 Aug 15;227(5259):680-5. (PMID: 5432063)
Clin Sci (Lond). 1990 Sep;79(3):221-6. (PMID: 2169369)
Braz J Med Biol Res. 2008 Sep;41(9):789-95. (PMID: 18820769)
Biophys Rev. 2017 Oct;9(5):807-825. (PMID: 28836190)
Biometals. 2010 Oct;23(5):769-82. (PMID: 20517707)
Biochemistry (Mosc). 2008 Feb;73(2):178-84. (PMID: 18298374)
Sci Total Environ. 2008 Dec 15;407(1):147-53. (PMID: 18845316)
Chem Biol Interact. 2014 Mar 25;211:54-65. (PMID: 24463198)
Int J Occup Med Environ Health. 2013 Jun;26(3):440-56. (PMID: 23857371)
Arch Toxicol. 1990;64(6):490-6. (PMID: 2148867)
Food Chem Toxicol. 2019 Mar;125:233-241. (PMID: 30634013)
Physiol Rev. 1999 Jan;79(1):215-62. (PMID: 9922372)
Life Sci. 2000 Dec 15;68(4):401-15. (PMID: 11205890)
Food Chem Toxicol. 2020 Oct;144:111641. (PMID: 32758638)
Circ Res. 1990 Oct;67(4):893-901. (PMID: 2208612)
PLoS One. 2014 May 19;9(5):e96900. (PMID: 24841481)
BMJ Open. 2015 Jun 15;5(6):e007366. (PMID: 26078311)
J Biomed Biotechnol. 2010;2010:789798. (PMID: 20379391)
Nanomaterials (Basel). 2021 Feb 01;11(2):. (PMID: 33535568)
Environ Res. 2010 Feb;110(2):199-206. (PMID: 20060521)
Int J Epidemiol. 2016 Jun;45(3):782-91. (PMID: 25997435)
Methods Enzymol. 1982;85 Pt B:164-81. (PMID: 7121269)
Arq Bras Cardiol. 2012 Mar;98(3):243-51. (PMID: 22344675)
Biol Trace Elem Res. 2015 Oct;167(2):280-7. (PMID: 25795172)
J Cardiovasc Pharmacol. 2000;35(4 Suppl 2):S3-5. (PMID: 10976772)
Free Radic Biol Med. 2014 Feb;67:366-76. (PMID: 24308934)
Pharmacol Toxicol. 2001 Dec;89(6):326-30. (PMID: 11903960)
Circ Res. 1987 Sep;61(3):318-28. (PMID: 3621495)
Environ Health Perspect. 2010 Dec;118(12):1676-84. (PMID: 20716508)
Toxicol Mech Methods. 2009 May;19(4):308-17. (PMID: 19778222)
PLoS One. 2011 Apr 11;6(4):e18730. (PMID: 21494558)
Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H8-H16. (PMID: 15961379)
Physiol Rev. 2000 Apr;80(2):853-924. (PMID: 10747208)
Biophys J. 2007 Mar 15;92(6):2199-211. (PMID: 17208981)
J Aerosol Med. 2005 Spring;18(1):1-22. (PMID: 15741770)
Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1446-54. (PMID: 12234796)
Mol Pharmacol. 1984 Jul;26(1):75-82. (PMID: 6087119)
Curr Atheroscler Rep. 2013 Oct;15(10):356. (PMID: 23955722)
Food Chem Toxicol. 2018 Oct;120:378-389. (PMID: 30036551)
Methods Enzymol. 1982;85 Pt B:241-63. (PMID: 7121270)
Discov Med. 2005 Apr;5(26):213-8. (PMID: 20704913)
Pharmacol Toxicol. 1995 Jan;76(1):9-16. (PMID: 7753767)
Toxicol Mech Methods. 2016 Feb;26(2):139-50. (PMID: 26894918)
Food Chem Toxicol. 2020 Feb;136:110971. (PMID: 31751644)
FEBS J. 2014 Apr;281(8):2004-16. (PMID: 24548721)
Am J Physiol. 1980 Jul;239(1):H22-30. (PMID: 7396014)
Toxicol Rep. 2020 Mar 02;7:433-442. (PMID: 32181144)
Am J Physiol. 1989 Sep;257(3 Pt 2):R599-604. (PMID: 2782462)
Nanotoxicology. 2021 Mar;15(2):205-222. (PMID: 33186499)
فهرسة مساهمة: Keywords: bioprotectors; cadmium; cardiotoxicity; combined action; in vitro motility assay; lead; myocardium contractility; myosin; nanoparticles; papillary muscles; trabeculae
المشرفين على المادة: 0 (Cadmium Compounds)
0 (Oxides)
0 (Protein Isoforms)
0H3KWS8KJ3 (cadmium oxide)
2P299V784P (Lead)
4IN6FN8492 (lead oxide)
EC 3.6.4.1 (Myosin Heavy Chains)
EC 3.6.4.1 (Myosins)
تواريخ الأحداث: Date Created: 20210403 Date Completed: 20210708 Latest Revision: 20210708
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8036427
DOI: 10.3390/ijms22073466
PMID: 33801669
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms22073466