دورية أكاديمية
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Transcriptomic Analysis Reveals Host miRNAs Correlated with Immune Gene Dysregulation during Fatal Disease Progression in the Ebola Virus Cynomolgus Macaque Disease Model.

التفاصيل البيبلوغرافية
العنوان: Transcriptomic Analysis Reveals Host miRNAs Correlated with Immune Gene Dysregulation during Fatal Disease Progression in the Ebola Virus Cynomolgus Macaque Disease Model.
المؤلفون: Stefan CP; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Arnold CE; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Shoemaker CJ; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Zumbrun EE; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Altamura LA; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Douglas CE; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Taylor-Howell CL; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Graham AS; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Delp KL; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Blancett CD; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Ricks KM; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Olschner SP; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Shamblin JD; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Wollen SE; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Zelko JM; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Bloomfield HA; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Sprague TR; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Esham HL; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA., Minogue TD; Diagnostic Systems Division, U.S. Army Medical Research Institute of Infectious Diseases, Ft. Detrick, MD 21702, USA.
المصدر: Microorganisms [Microorganisms] 2021 Mar 23; Vol. 9 (3). Date of Electronic Publication: 2021 Mar 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101625893 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2607 (Print) Linking ISSN: 20762607 NLM ISO Abbreviation: Microorganisms Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Ebola virus is a continuing threat to human populations, causing a virulent hemorrhagic fever disease characterized by dysregulation of both the innate and adaptive host immune responses. Severe cases are distinguished by an early, elevated pro-inflammatory response followed by a pronounced lymphopenia with B and T cells unable to mount an effective anti-viral response. The precise mechanisms underlying the dysregulation of the host immune system are poorly understood. In recent years, focus on host-derived miRNAs showed these molecules to play an important role in the host gene regulation arsenal. Here, we describe an investigation of RNA biomarkers in the fatal Ebola virus disease (EVD) cynomolgus macaque model. We monitored both host mRNA and miRNA responses in whole blood longitudinally over the disease course in these non-human primates (NHPs). Analysis of the interactions between these classes of RNAs revealed several miRNA markers significantly correlated with downregulation of genes; specifically, the analysis revealed those involved in dysregulated immune pathways associated with EVD. In particular, we noted strong interactions between the miRNAs hsa-miR-122-5p and hsa-miR-125b-5p with immunological genes regulating both B and T-cell activation. This promising set of biomarkers will be useful in future studies of severe EVD pathogenesis in both NHPs and humans and may serve as potential prognostic targets.
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معلومات مُعتمدة: CB10245 Defense Threat Reduction Agency
فهرسة مساهمة: Keywords: Ebola virus; apoptosis; cytokine; immunology; inflammation; mRNA; miRNA; non-human primate; pathogenesis; transcriptome
تواريخ الأحداث: Date Created: 20210403 Latest Revision: 20210413
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8005181
DOI: 10.3390/microorganisms9030665
PMID: 33806942
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-2607
DOI:10.3390/microorganisms9030665