دورية أكاديمية

IgA vasculitis with nephritis: update of pathogenesis with clinical implications.

التفاصيل البيبلوغرافية
العنوان: IgA vasculitis with nephritis: update of pathogenesis with clinical implications.
المؤلفون: Hastings MC; Division of Pediatric Nephrology and Hypertension, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.; Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.; Children's Foundation Research Institute at the Le Bonheur Children's Hospital, Memphis, TN, USA., Rizk DV; Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA., Kiryluk K; Division of Nephrology, Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, NY, USA., Nelson R; Division of Pediatric Nephrology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA., Zahr RS; Division of Pediatric Nephrology and Hypertension, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA.; Children's Foundation Research Institute at the Le Bonheur Children's Hospital, Memphis, TN, USA., Novak J; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA., Wyatt RJ; Division of Pediatric Nephrology and Hypertension, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA. rwyatt@uthsc.edu.; Children's Foundation Research Institute at the Le Bonheur Children's Hospital, Memphis, TN, USA. rwyatt@uthsc.edu.
المصدر: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2022 Apr; Vol. 37 (4), pp. 719-733. Date of Electronic Publication: 2021 Apr 05.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer International
Original Publication: Berlin : Springer International, c1987-
مواضيع طبية MeSH: Glomerulonephritis, IGA*/complications , IgA Vasculitis* , Nephritis*/etiology, Child ; Galactose ; Humans ; Immunoglobulin A ; Kidney Glomerulus/pathology
مستخلص: IgA vasculitis with nephritis (IgAVN) shares many pathogenetic features with IgA nephropathy (IgAN). The purpose of this review is to describe our current understanding of the pathogenesis of pediatric IgAVN, particularly as it relates to the four-hit hypothesis for IgAN. These individual steps, i.e., hits, in the pathogenesis of IgAN are (1) elevated production of IgA1 glycoforms with some O-glycans deficient in galactose (galactose-deficient IgA1; Gd-IgA1), (2) generation of circulating IgG autoantibodies specific for Gd-IgA1, (3) formation of pathogenic circulating Gd-IgA1-containing immune complexes, and (4) kidney deposition of the Gd-IgA1-IgG immune complexes from the circulation and induction of glomerular injury. Evidence supporting the four-hit hypothesis in the pathogenesis of pediatric IgAVN is detailed. The genetics, pediatric outcomes, and kidney histopathologic features and the impact of these findings on future treatment and potential biomarkers are discussed. In summary, the evidence points to the critical roles of Gd-IgA1-IgG immune complexes and complement activation in the pathogenesis of IgAVN. Future studies are needed to characterize the features of the immune and autoimmune responses that enable progression of IgA vasculitis to IgAVN.
(© 2021. IPNA.)
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معلومات مُعتمدة: R01 DK105124 United States DK NIDDK NIH HHS; R01 DK078244 United States DK NIDDK NIH HHS; R01 DK082753 United States DK NIDDK NIH HHS; RC2 DK116690 United States DK NIDDK NIH HHS; R56 DK078244 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Children; Henoch-Schönlein purpura; IgA vasculitis; IgA1 glycoforms; IgAVN; Progression
المشرفين على المادة: 0 (Immunoglobulin A)
X2RN3Q8DNE (Galactose)
تواريخ الأحداث: Date Created: 20210405 Date Completed: 20220406 Latest Revision: 20230402
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8490493
DOI: 10.1007/s00467-021-04950-y
PMID: 33818625
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-198X
DOI:10.1007/s00467-021-04950-y