دورية أكاديمية
أعرض في EDS

Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy.

التفاصيل البيبلوغرافية
العنوان: Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy.
المؤلفون: Shamji MH; National Heart and Lung Institute, Allergy and Clinical Immunology, Imperial College NIHR Biomedical Research Centre, Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom. Electronic address: m.shamji@imperial.ac.uk., Larson D; Immune Tolerance Network, Bethesda, Md., Eifan A; National Heart and Lung Institute, Allergy and Clinical Immunology, Imperial College NIHR Biomedical Research Centre, Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Scadding GW; National Heart and Lung Institute, Allergy and Clinical Immunology, Imperial College NIHR Biomedical Research Centre, Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Qin T; Immune Tolerance Network, Bethesda, Md., Lawson K; Rho Federal Systems Division, Durham, NC., Sever ML; Rho Federal Systems Division, Durham, NC., Macfarlane E; National Heart and Lung Institute, Allergy and Clinical Immunology, Imperial College NIHR Biomedical Research Centre, Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Layhadi JA; National Heart and Lung Institute, Allergy and Clinical Immunology, Imperial College NIHR Biomedical Research Centre, Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Würtzen PA; Translational Research, ALK, Hørsholm, Denmark., Parkin RV; National Heart and Lung Institute, Allergy and Clinical Immunology, Imperial College NIHR Biomedical Research Centre, Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom., Sanda S; Immune Tolerance Network, San Francisco, Calif., Harris KM; Immune Tolerance Network, Bethesda, Md., Nepom GT; Immune Tolerance Network, Bethesda, Md; Benaroya Research Institute at Virginia Mason, Seattle, Wash., Togias A; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Md., Durham SR; National Heart and Lung Institute, Allergy and Clinical Immunology, Imperial College NIHR Biomedical Research Centre, Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom; Immune Tolerance Network, Bethesda, Md.
المصدر: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Oct; Vol. 148 (4), pp. 1061-1071.e11. Date of Electronic Publication: 2021 Apr 02.
نوع المنشور: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: St Louis, Mosby.
مواضيع طبية MeSH: Desensitization, Immunologic*, Allergens/*immunology , Immunoglobulins/*immunology , Phleum/*immunology , Pollen/*immunology, Administration, Sublingual ; Adult ; B-Lymphocytes/immunology ; Double-Blind Method ; Female ; Humans ; Immunoglobulins/blood ; Injections, Subcutaneous ; Male ; Nasal Mucosa/immunology
مستخلص: Introduction: There is no detailed comparison of allergen-specific immunoglobulin responses following sublingual immunotherapy (SLIT) and subcutaneous immunotherapy (SCIT).
Objective: We sought to compare nasal and systemic timothy grass pollen (TGP)-specific antibody responses during 2 years of SCIT and SLIT and 1 year after treatment discontinuation in a double-blind, double-dummy, placebo-controlled trial.
Methods: Nasal fluid and serum were obtained yearly (per-protocol population, n = 84). TGP-specific IgA 1 , IgA 2 , IgG 4 , IgG, and IgE were measured in nasal fluids by ELISA. TGP-specific IgA 1 , IgA 2 , and Phleum pratense (Phl p)1, 2, 4, 5b, 6, 7, 11, and 12 IgE and IgG 4 were measured in sera by ELISA and ImmunoCAP, respectively.
Results: At years 2 and 3, TGP-IgA 1/2 levels in nasal fluid were elevated in SLIT compared with SCIT (4.2- and 3.0-fold for IgA 1 , 2.0- and 1.8-fold for IgA 2 , respectively; all P < .01). TGP-IgA 1 level in serum was elevated in SLIT compared with SCIT at years 1, 2, and 3 (4.6-, 5.1-, and 4.7-fold, respectively; all P < .001). Serum TGP-IgG level was higher in SCIT compared with SLIT (2.8-fold) at year 2. Serum TGP-IgG 4 level was higher in SCIT compared with SLIT at years 1, 2, and 3 (10.4-, 27.4-, and 5.1-fold, respectively; all P < .01). Serum IgG 4 levels to Phl p1, 2, 5b, and 6 were increased at years 1, 2, and 3 in SCIT and SLIT compared with placebo (Phl p1: 11.8- and 3.9-fold; Phl p2: 31.6- and 4.4-fold; Phl p5b: 135.5- and 5.3-fold; Phl p6: 145.4- and 14.7-fold, respectively, all at year 2 when levels peaked; P < .05). IgE to TGP in nasal fluid increased in the SLIT group at year 2 but not at year 3 compared with SCIT (2.8-fold; P = .04) and placebo (3.1-fold; P = .02). IgA to TGP and IgE and IgG 4 to TGP components stratified participants according to treatment group and clinical response.
Conclusions: The observed induction of IgA 1/2 in SLIT and IgG 4  in SCIT suggest key differences in the mechanisms of action.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
معلومات مُعتمدة: G0601303 United Kingdom MRC_ Medical Research Council; UM1 AI109565 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: IgA(1); IgA(2); IgE-FAB; IgG(4); Sublingual immunotherapy; allergic rhinitis; blocking antibodies; subcutaneous immunotherapy
المشرفين على المادة: 0 (Allergens)
0 (Immunoglobulins)
تواريخ الأحداث: Date Created: 20210405 Date Completed: 20211119 Latest Revision: 20230308
رمز التحديث: 20230308
DOI: 10.1016/j.jaci.2021.03.030
PMID: 33819508
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-6825
DOI:10.1016/j.jaci.2021.03.030