دورية أكاديمية
Safety evaluation of orally-administered methanol extract of Muntingia calabura Linn. leaves: A sub-chronic toxicity study in Sprague Dawley rats.
| العنوان: | Safety evaluation of orally-administered methanol extract of Muntingia calabura Linn. leaves: A sub-chronic toxicity study in Sprague Dawley rats. |
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| المؤلفون: | Nasir NLM; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia., Kamsani NE; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia., Mohtarrudin N; Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Serdang, Malaysia., Tohid SFM; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia., Zakaria ZA; Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia / Integrative Pharmacogenomic Institute, Level 7, FF3 Building, Universiti Teknologi MARA, Selangor, Malaysia. |
| المصدر: | Pakistan journal of pharmaceutical sciences [Pak J Pharm Sci] 2020 Sep; Vol. 33 (5), pp. 2009-2016. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Internet ISSN: 1011-601X (Print) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Karachi : Faculty of Pharmacy, University of Karachi, [1988- |
| مواضيع طبية MeSH: | Malvales*/chemistry , Malvales*/toxicity , Plant Leaves*/chemistry , Plant Leaves*/toxicity, Antioxidants/*toxicity , Plant Extracts/*toxicity, Administration, Oral ; Animals ; Antioxidants/administration & dosage ; Antioxidants/isolation & purification ; Male ; Methanol/chemistry ; Plant Extracts/administration & dosage ; Plant Extracts/isolation & purification ; Rats, Sprague-Dawley ; Risk Assessment ; Solvents/chemistry ; Time Factors ; Toxicity Tests, Subchronic |
| مستخلص: | Muntingia calabura (M. calabura), locally known as "kerukup siam" or "buah ceri" belongs to the family Muntingiaceae and has been scientifically demonstrated to exert various pharmacological activities. The objectives of the current study are to evaluate the antioxidant activities and to determine the subchronic toxicity of 90 days orally-administered methanol extract of M. calabura (MEMC) in male Sprague Dawley rats. The rats were randomly divided into four groups (n=6). Vehicle control received 8% tween 80 and treatment group received 50, 250 and 500 mg/kg of MEMC orally administered daily for 90 days. Blood collection was carried out to obtain the hematological and biochemical profile of the rats. The organs harvested were subjected to histopathological analysis. For the antioxidant test, the extract was subjected to antioxidant study using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH)- and superoxide anion-radical scavenging activity, total phenolic content (TPC) and phytochemical screening. Results obtained show that no adverse effects were observed during the experimental period. Hematological and biochemical analysis also showed no significant changes in this toxicity study. Besides, antioxidant analyses revealed that MEMC has higher DPPH- and SOD-radical scavenges activity as well as higher TPC value. In conclusion, M. calabura is safe for consumption and possesses beneficial antioxidant effect. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Plant Extracts) 0 (Solvents) Y4S76JWI15 (Methanol) |
| تواريخ الأحداث: | Date Created: 20210407 Date Completed: 20211109 Latest Revision: 20211109 |
| رمز التحديث: | 20221213 |
| PMID: | 33824108 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1011-601X |
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