دورية أكاديمية
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An Exercise Mimetic Approach to Reduce Poststroke Deconditioning and Enhance Stroke Recovery.

التفاصيل البيبلوغرافية
العنوان: An Exercise Mimetic Approach to Reduce Poststroke Deconditioning and Enhance Stroke Recovery.
المؤلفون: McDonald MW; University of Ottawa, ON, Canada.; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada., Jeffers MS; University of Ottawa, ON, Canada.; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada., Issa L; University of Ottawa, ON, Canada., Carter A; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada.; Ottawa Hospital Research Institute, ON, Canada., Ripley A; University of Ottawa, ON, Canada., Kuhl LM; University of Ottawa, ON, Canada., Morse C; University of Ottawa, ON, Canada., Comin CH; Federal University of São Carlos, SP, Brazil., Jasmin BJ; University of Ottawa, ON, Canada., Lacoste B; University of Ottawa, ON, Canada.; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada.; Ottawa Hospital Research Institute, ON, Canada.; University of Ottawa Brain and Mind Research Institute, ON, Canada., Corbett D; University of Ottawa, ON, Canada.; Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada.; University of Ottawa Brain and Mind Research Institute, ON, Canada.
المصدر: Neurorehabilitation and neural repair [Neurorehabil Neural Repair] 2021 Jun; Vol. 35 (6), pp. 471-485. Date of Electronic Publication: 2021 Apr 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 100892086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-6844 (Electronic) Linking ISSN: 15459683 NLM ISO Abbreviation: Neurorehabil Neural Repair Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : Thousand Oaks, CA : Sage Publications
Original Publication: New York, NY : Demos Medical Pub., c1999-
مواضيع طبية MeSH: Cardiovascular Deconditioning*/drug effects , Cardiovascular Deconditioning*/physiology , Muscle, Skeletal*/drug effects , Muscle, Skeletal*/physiopathology , Recovery of Function*/drug effects , Recovery of Function*/physiology , Resistance Training* , Stroke Rehabilitation*, Antioxidants/*pharmacology , Physical Conditioning, Animal/*physiology , Resveratrol/*pharmacology , Stroke/*therapy, Animals ; Antioxidants/administration & dosage ; Behavior, Animal/drug effects ; Behavior, Animal/physiology ; Combined Modality Therapy ; Disease Models, Animal ; Female ; Hindlimb/drug effects ; Hindlimb/physiopathology ; Rats ; Rats, Sprague-Dawley ; Resveratrol/administration & dosage ; Sensorimotor Cortex/drug effects ; Sensorimotor Cortex/physiopathology ; Stroke/drug therapy
مستخلص: Evidence supports early rehabilitation after stroke to limit disability. However, stroke survivors are typically sedentary and experience significant cardiovascular and muscular deconditioning. Despite growing consensus that preclinical and clinical stroke recovery research should be aligned, there have been few attempts to incorporate cardiovascular and skeletal muscle deconditioning into animal models of stroke. Here, we demonstrate in rats that a hindlimb sensorimotor cortex stroke results in both cardiovascular and skeletal muscle deconditioning and impairments in gait akin to those observed in humans. To reduce poststroke behavioral, cardiovascular, and skeletal muscle perturbations, we then used a combinatorial intervention consisting of aerobic and resistance exercise in conjunction with administration of resveratrol (RESV), a drug with exercise mimetic properties. A combination of aerobic and resistance exercise mitigated decreases in cardiovascular fitness and attenuated skeletal muscle abnormalities. RESV, beginning 24 hours poststroke, reduced acute hindlimb impairments, improved recovery in hindlimb function, increased vascular density in the perilesional cortex, and attenuated skeletal muscle fiber changes. Early RESV treatment and aerobic and resistance exercise independently provided poststroke benefits, at a time when individuals are rapidly becoming deconditioned as a result of inactivity. Although no additive effects were observed in these experiments, this approach represents a promising strategy to reduce poststroke behavioral impairments and minimize deconditioning. As such, this treatment regime has potential for enabling patients to engage in more intensive rehabilitation at an earlier time following stroke when mechanisms of neuroplasticity are most prevalent.
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فهرسة مساهمة: Keywords: aerobic exercise; angiogenesis; cardiovascular; resistance exercise; skeletal muscle
المشرفين على المادة: 0 (Antioxidants)
Q369O8926L (Resveratrol)
تواريخ الأحداث: Date Created: 20210407 Date Completed: 20220106 Latest Revision: 20220106
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8135250
DOI: 10.1177/15459683211005019
PMID: 33825581
قاعدة البيانات: MEDLINE
الوصف
تدمد:1552-6844
DOI:10.1177/15459683211005019