دورية أكاديمية
أعرض في EDS

Effects of intraventricular hemorrhage on white matter microstructural changes at term and early developmental outcomes in infants born very preterm.

التفاصيل البيبلوغرافية
العنوان: Effects of intraventricular hemorrhage on white matter microstructural changes at term and early developmental outcomes in infants born very preterm.
المؤلفون: Yuan W; Pediatric Neuroimaging Research Consortium, Division of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Tamm L; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Harpster K; Division of Occupational Therapy and Physical Therapy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Altaye M; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.; University of Cincinnati College of Medicine, Cincinnati, OH, USA., Illapani VSP; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Parikh NA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Nehal.Parikh@cchmc.org.; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Nehal.Parikh@cchmc.org.; University of Cincinnati College of Medicine, Cincinnati, OH, USA. Nehal.Parikh@cchmc.org.
المصدر: Neuroradiology [Neuroradiology] 2021 Sep; Vol. 63 (9), pp. 1549-1561. Date of Electronic Publication: 2021 Apr 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 1302751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1920 (Electronic) Linking ISSN: 00283940 NLM ISO Abbreviation: Neuroradiology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: Infant, Premature, Diseases* , White Matter*/diagnostic imaging, Cerebral Hemorrhage/diagnostic imaging ; Diffusion Tensor Imaging ; Humans ; Infant ; Infant, Extremely Premature ; Infant, Newborn
مستخلص: Purpose: Very preterm (VPT) infants are at high risk for motor and behavioral deficits. We investigated microstructural differences using diffusion tensor imaging (DTI) among VPT infants with different grades of intraventricular hemorrhage (IVH), their association with early motor function and temperament ratings, and the potential moderating effect of IVH severity on the above structure-function relations.
Methods: Fifty-seven VPT (≤32 weeks gestational age) infants with IVH (Low Grade (Papile grading I/II): 42; High Grade (III/IV): 15) were studied. DTI was acquired between 39 and 44 weeks postmenstrual age and was analyzed using the tract-based spatial statistics approach. Early motor function and temperament were assessed at 3-month corrected age based on the Hammersmith Infant Neurological Examination (HINE) and Infant Behavioral Questionnaire - Revised, Short Version (IBQ-R-S), respectively.
Results: Significantly lower fractional anisotropy and higher mean, axial, and/or radial diffusivity were found in VPT infants with High Grade IVH compared to Low Grade IVH (p < 0.05). Significant associations were found between DTI metrics and motor function in both IVH groups and between DTI and Fear temperament ratings in the High Grade IVH Group (all p < 0.05). IVH severity had a significant moderating effect on the relation between DTI and motor and Fear ratings (p < 0.05).
Conclusion: DTI is a sensitive neuroimaging biomarker providing a refined understanding of the impact and location of differing severities of IVH on the developing white matter of VPT infants. Early motor and behavioral outcomes are associated with microstructural changes that are influenced by severity of IVH.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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معلومات مُعتمدة: R01 NS094200 United States NS NINDS NIH HHS; R01 NS096037 United States NS NINDS NIH HHS; R01-NS094200 United States NS NINDS NIH HHS; R01-NS096037 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: DTI; Intraventricular hemorrhage severity; Motor; Temperament; Very preterm
تواريخ الأحداث: Date Created: 20210408 Date Completed: 20210929 Latest Revision: 20210929
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8376788
DOI: 10.1007/s00234-021-02708-9
PMID: 33830309
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1920
DOI:10.1007/s00234-021-02708-9