دورية أكاديمية
Being overweight is associated with not reaching low disease activity in women but not men with psoriatic arthritis.
| العنوان: | Being overweight is associated with not reaching low disease activity in women but not men with psoriatic arthritis. |
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| المؤلفون: | Mulder MLM; Department of Rheumatology, Sint Maartenskliniek.; Department of Dermatology, Radboud University Medical Center., Wenink MH; Department of Rheumatology, Sint Maartenskliniek., Vriezekolk JE; Department of Rheumatology, Sint Maartenskliniek.; Department of Rheumatology Research, Sint Maartenskliniek, Nijmegen, The Netherlands. |
| المصدر: | Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2022 Feb 02; Vol. 61 (2), pp. 770-774. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Avenel, N.J. : Oxford University Press ; Distributed by Mercury International, c1999- |
| مواضيع طبية MeSH: | Arthritis, Psoriatic/*etiology , Overweight/*complications, Anti-Inflammatory Agents/therapeutic use ; Arthralgia/etiology ; Arthralgia/pathology ; Arthritis, Psoriatic/drug therapy ; Arthritis, Psoriatic/pathology ; Cross-Sectional Studies ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Pain Measurement ; Patient Acuity ; Quality of Life ; Sex Factors ; Treatment Outcome |
| مستخلص: | Objective: To assess sex differences in disease activity parameters and health-related quality of life in PsA, and to assess whether determinants associated with not reaching treatment target differed between men and women. Methods: Routine practice data of 855 PsA patients, who were all tightly monitored and treated, was used. Sex differences including, but not limited to, PsA Disease Activity Score (PASDAS), skin/nail disease, SF-12 PCS/MCS, and inflammatory back pain (IBP) were assessed. Multivariate analyses were used to examine determinants associated with not reaching treatment target (PASDAS ≤ 3.2) in men and women. Results: Women had worse scores for-among others-swollen and tender joints, CRP, enthesitis and function (all P < 0.001). Higher PASDAS scores were found for women [3.5 (1.5)] than men [2.7 (1.5), P < 0.001]. Likewise, women were more often not at PASDAS treatment target (OR = 2.03, P < 0.001). No difference in current medication use was found. Nail disease, IBP, number of DMARDs used (past and current), and BMI were associated with not reaching treatment target in the overall sample. For women, but not men, BMI was associated with not reaching PASDAS low disease activity (LDA) (OR between 2.41 and 3.43, P < 0.001). Conclusions: Women with PsA in a tightly monitored and treated setting have more severe disease than men. This is demonstrated by worse scores for women in both subjective and objective disease activity measures, in addition to women less often reaching the treatment target. Notably, being overweight is associated with higher disease activity in women, but not men. (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: BMI; Psoriatic Arthritis Disease Activity Score (PASDAS); disease activity; psoriatic arthritis; sex |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) |
| تواريخ الأحداث: | Date Created: 20210408 Date Completed: 20220309 Latest Revision: 20220309 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1093/rheumatology/keab338 |
| PMID: | 33831180 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1462-0332 |
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| DOI: | 10.1093/rheumatology/keab338 |