دورية أكاديمية
أعرض في EDS

Acute kidney injury is more common in men than women after accounting for socioeconomic status, ethnicity, alcohol intake and smoking history.

التفاصيل البيبلوغرافية
العنوان: Acute kidney injury is more common in men than women after accounting for socioeconomic status, ethnicity, alcohol intake and smoking history.
المؤلفون: Loutradis C; Department of Renal Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK. loutradis_haris@hotmail.com.; Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. loutradis_haris@hotmail.com., Pickup L; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, Edgbaston, Birmingham, B15 2TT, UK.; Warwick Medical School, University of Warwick, Coventry, CV4 7HL, UK., Law JP; Department of Renal Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK.; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, Edgbaston, Birmingham, B15 2TT, UK., Dasgupta I; Department of Renal Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK.; Warwick Medical School, University of Warwick, Coventry, CV4 7HL, UK., Townend JN; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, Edgbaston, Birmingham, B15 2TT, UK.; Department of Cardiology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK., Cockwell P; Department of Renal Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK., Sharif A; Department of Renal Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK., Sarafidis P; Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Ferro CJ; Department of Renal Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2GW, UK.; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, Edgbaston, Birmingham, B15 2TT, UK.
المصدر: Biology of sex differences [Biol Sex Differ] 2021 Apr 08; Vol. 12 (1), pp. 30. Date of Electronic Publication: 2021 Apr 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101548963 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-6410 (Electronic) Linking ISSN: 20426410 NLM ISO Abbreviation: Biol Sex Differ Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2010-
مواضيع طبية MeSH: Acute Kidney Injury*/epidemiology, Adult ; Aged ; Aged, 80 and over ; Alcohol Drinking/epidemiology ; Ethnicity ; Female ; Humans ; Male ; Middle Aged ; Sex Characteristics ; Smoking ; Social Class
مستخلص: Background: The association of several comorbidities, including diabetes mellitus, hypertension, cardiovascular disease, heart failure and chronic kidney or liver disease, with acute kidney injury (AKI) is well established. Evidence on the effect of sex and socioeconomic factors are scarce. This study was designed to examine the association of sex and socioeconomic factors with AKI and AKI-related mortality and further to evaluate the additional relationship with other possible risk factors for AKI occurrence.
Methods: We included 3534 patients (1878 males with mean age 61.1 ± 17.7 and 1656 females 1656 with mean age 60.3 ± 20.0 years) admitted to Queen Elizabeth or Heartlands Hospitals, Birmingham, between October 2013 and January 2016. Patients were prospectively followed-up for a median 47.70 [IQR, 18.20] months. Study-endpoints were incidence of AKI, based on KDIGO-AKI Guidelines, and all-cause mortality. Data acquisition was automated, and information on mortality was collected from the Hospital Episode Statistics and Office of National Statistics. Socioeconomic status was evaluated with the Index of Multiple Deprivation (IMD).
Results: Incidence of AKI was higher in men compared to women (11.3% vs 7.1%; P < 0.001). Model regression analysis revealed significant association of male sex with higher AKI risk (OR, 1.659; 95% CI, 1.311-2.099; P < 0.001); this association remained significant after adjustment for age, eGFR, IMD, smoking, alcohol consumption, ethnicity, existing comorbidities and treatment (OR, 1.599; 95% CI, 1.215-2.103; P = 0.001). All-cause mortality was higher in patients with compared to those without AKI. Males with AKI had higher mortality rates in the first 6-month and 1-year periods after the index AKI event. The association of male sex with mortality was independent of socioeconomic factors but was not statistically significant after adjustment for existing comorbidities.
Conclusions: Men are at higher risk of AKI and this association is independent from existing risk factors for AKI. The association between male sex and AKI-related mortality was not independent from existing comorbidities. A better understanding of factors associated with AKI may help accurately identify high-risk patients.
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معلومات مُعتمدة: FS/19/16/34169 United Kingdom BHF_ British Heart Foundation; FS/16/73/32314 United Kingdom BHF_ British Heart Foundation
فهرسة مساهمة: Keywords: Acute kidney injury; Alcohol; Mortality; Sex; Smoking; Social status
تواريخ الأحداث: Date Created: 20210409 Date Completed: 20211208 Latest Revision: 20240809
رمز التحديث: 20240809
مُعرف محوري في PubMed: PMC8034098
DOI: 10.1186/s13293-021-00373-4
PMID: 33832522
قاعدة البيانات: MEDLINE
الوصف
تدمد:2042-6410
DOI:10.1186/s13293-021-00373-4