دورية أكاديمية
Yeasts as a promising delivery platform for DNA and RNA vaccines.
| العنوان: | Yeasts as a promising delivery platform for DNA and RNA vaccines. |
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| المؤلفون: | Silva AJD; Laboratório de Estudos Moleculares e Terapia Experimental, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rêgo, 1235, Cidade Universitaria, Recife, Pernambuco, Brazil., de Macêdo LS; Laboratório de Estudos Moleculares e Terapia Experimental, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rêgo, 1235, Cidade Universitaria, Recife, Pernambuco, Brazil., Leal LRS; Laboratório de Estudos Moleculares e Terapia Experimental, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rêgo, 1235, Cidade Universitaria, Recife, Pernambuco, Brazil., de Jesus ALS; Laboratório de Estudos Moleculares e Terapia Experimental, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rêgo, 1235, Cidade Universitaria, Recife, Pernambuco, Brazil., Freitas AC; Laboratório de Estudos Moleculares e Terapia Experimental, Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rêgo, 1235, Cidade Universitaria, Recife, Pernambuco, Brazil. |
| المصدر: | FEMS yeast research [FEMS Yeast Res] 2021 Apr 07; Vol. 21 (3). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101085384 Publication Model: Print Cited Medium: Internet ISSN: 1567-1364 (Electronic) Linking ISSN: 15671356 NLM ISO Abbreviation: FEMS Yeast Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Oxford Oxford University Press Original Publication: Amsterdam ; New York : Published by Elsevier Science B.V. on behalf of Federation of European Microbiological Societies, [2001- |
| مواضيع طبية MeSH: | Drug Delivery Systems*, Vaccines, DNA/*genetics , Vaccines, Synthetic/*genetics , Yeasts/*genetics, Humans ; Saccharomyces cerevisiae/genetics ; Saccharomycetales/genetics ; Vaccines, DNA/administration & dosage ; Vaccines, Subunit ; Vaccines, Synthetic/administration & dosage ; mRNA Vaccines |
| مستخلص: | Yeasts are considered a useful system for the development of vaccines for human and veterinary health. Species such as Saccharomyces cerevisiae and Pichia pastoris have been used successfully as host organisms for the production of subunit vaccines. These organisms have been also explored as vaccine vehicles enabling the delivery of antigens such as proteins and nucleic acids. The employed species possess a GRAS status (Generally Recognized as Safe) for the production of therapeutic proteins, besides promoting immunostimulation due to the properties of their wall cell composition. This strategy allows the administration of nucleic acids orally and a specific delivery to professional antigen-presenting cells (APCs). In this review, we seek to outline the development of whole yeast vaccines (WYV) carrying nucleic acids in different approaches in the medical field, as well as the immunological aspects of this vaccine strategy. The data presented here reveal the application of this platform in promoting effective immune responses in the context of prophylactic and therapeutic approaches. (© The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.) |
| فهرسة مساهمة: | Keywords: adjuvant; antigenic vehicle; immunomodulation; immunotherapy; nucleic acids; whole yeast vaccines |
| المشرفين على المادة: | 0 (Vaccines, DNA) 0 (Vaccines, Subunit) 0 (Vaccines, Synthetic) |
| SCR Organism: | Komagataella pastoris |
| تواريخ الأحداث: | Date Created: 20210410 Date Completed: 20211104 Latest Revision: 20231213 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1093/femsyr/foab018 |
| PMID: | 33837785 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1567-1364 |
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| DOI: | 10.1093/femsyr/foab018 |