دورية أكاديمية
Melatonin administration attenuates acute stress by inducing sleep state in zebrafish (Danio rerio).
| العنوان: | Melatonin administration attenuates acute stress by inducing sleep state in zebrafish (Danio rerio). |
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| المؤلفون: | Lunkes LC; Federal University of Lavras, Graduate Program in Veterinary Sciences, Department of Veterinary Medicine, Lavras, MG, Brazil., Paiva IM; Federal University of Minas Gerais, Graduate Program in Genetics, Institute of Biological Sciences, Belo Horizonte, MG, Brazil., Egger RC; Federal University of Lavras, Graduate Program in Veterinary Sciences, Department of Veterinary Medicine, Lavras, MG, Brazil., Braga WF; Federal University of Minas Gerais, Postgraduate Program in Biochemistry and Immunology, Department of Biochemistry and Immunology, Belo Horizonte, MG, Brazil., Alvarez-Leite JI; Federal University of Minas Gerais, Postgraduate Program in Biochemistry and Immunology, Department of Biochemistry and Immunology, Belo Horizonte, MG, Brazil., da Cunha Barreto-Vianna AR; Federal University of Paraná, Department of Biocience, Palotina, PR, Brazil., Murgas LDS; Federal University of Lavras, Graduate Program in Veterinary Sciences, Department of Veterinary Medicine, Lavras, MG, Brazil. Electronic address: lsmurgas@dmv.ufla.br. |
| المصدر: | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [Comp Biochem Physiol C Toxicol Pharmacol] 2021 Aug; Vol. 246, pp. 109044. Date of Electronic Publication: 2021 Apr 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 100959500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-0456 (Print) Linking ISSN: 15320456 NLM ISO Abbreviation: Comp Biochem Physiol C Toxicol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier Science, c2000- |
| مواضيع طبية MeSH: | Antioxidants/*pharmacology , Melatonin/*pharmacology , Oxidative Stress/*drug effects , Sleep/*drug effects, Animals ; Hydrocortisone/metabolism ; Zebrafish |
| مستخلص: | Melatonin plays a fundamental homeostatic role in basic biological functions, and an anti-stress role has been also proposed for this hormone. This study aimed to evaluate hormonal, enzymatic and behavioral parameters of zebrafish that received administration of melatonin and were submitted to acute stress. A total of 120 wild-type zebrafish were divided into five groups: naïve control (N), negative control group (Stress/C), positive control treated with diazepam (Stress/Diaz), treatment with melatonin at dose 1 (Stress/Melt. 1) and treatment with melatonin at dose 2 (Stress/Melt. 2). The exposure to treatments (diazepam or melatonin) was performed prior to the acute stress protocol, based on a chase by a fishing net during 5 min followed by exposure to the air for 1 min. The body cortisol levels were assessed, as well as oxidative stress (thiobarbituric acid reactive substances, reactive species of oxygen and antioxidant activity), and fish behavior (open field test). Melatonin was able to modulate acute stress effects on zebrafish by inhibiting cortisol increasing levels, reducing locomotor parameters, inducing a sleep state, reducing lipid peroxidation and stimulating antioxidant enzymatic activity. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anxiety; Behavior; Fish; Hormone; Melatonin; Oxidative stress |
| المشرفين على المادة: | 0 (Antioxidants) JL5DK93RCL (Melatonin) WI4X0X7BPJ (Hydrocortisone) |
| تواريخ الأحداث: | Date Created: 20210410 Date Completed: 20211006 Latest Revision: 20211006 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.cbpc.2021.109044 |
| PMID: | 33838315 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-0456 |
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| DOI: | 10.1016/j.cbpc.2021.109044 |