دورية أكاديمية
أعرض في EDS

Correlation between BAL CXCR3 chemokines and lung allograft histopathologies: A multicenter study.

التفاصيل البيبلوغرافية
العنوان: Correlation between BAL CXCR3 chemokines and lung allograft histopathologies: A multicenter study.
المؤلفون: Shino MY; Division of Pulmonary and Critical Care Medicine, University of California Los Angeles, Los Angeles, CA, USA., Li N; Division of Pulmonary and Critical Care Medicine, University of California Los Angeles, Los Angeles, CA, USA., Todd JL; Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA., Neely ML; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA., Kirchner J; Clinical Research Institute, Duke University Medical Center, Durham, NC, USA., Kopetskie H; Rho Federal Systems Division, Rho, Durham, NC, USA., Sever ML; Rho Federal Systems Division, Rho, Durham, NC, USA., Frankel CW; Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA., Snyder LD; Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA., Pavlisko EN; Department of Pathology, Duke University Medical Center, Durham, NC, USA., Martinu T; Division of Respirology, University Health Network, University of Toronto, Ontario, Canada., Singer LG; Division of Respirology, University Health Network, University of Toronto, Ontario, Canada., Tsuang W; Respiratory Institute/Division of Pulmonary and Critical Care Medicine, Cleveland Clinic, Cleveland, OH, USA., Budev M; Respiratory Institute/Division of Pulmonary and Critical Care Medicine, Cleveland Clinic, Cleveland, OH, USA., Shah PD; Division of Pulmonary and Critical Care Medicine, John Hopkins University, Baltimore, MD, USA., Reynolds JM; Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA., Williams N; Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA., Robien MA; Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Rockville, MD, USA., Palmer SM; Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA., Sam Weigt S; Division of Pulmonary and Critical Care Medicine, University of California Los Angeles, Los Angeles, CA, USA., Belperio JA; Division of Pulmonary and Critical Care Medicine, University of California Los Angeles, Los Angeles, CA, USA.
المصدر: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2021 Oct; Vol. 21 (10), pp. 3401-3410. Date of Electronic Publication: 2021 Jun 16.
نوع المنشور: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York] : Elsevier
Original Publication: Copenhagen : Munksgaard International Publishers, 2001-
مواضيع طبية MeSH: Chemokine CXCL10* , Graft Rejection*/etiology, Allografts ; Chemokine CXCL9 ; Lung ; Prospective Studies
مستخلص: The histopathologic diagnosis of acute allograft injury is prognostically important in lung transplantation with evidence demonstrating a strong and consistent association between acute rejection (AR), acute lung injury (ALI), and the subsequent development of chronic lung allograft dysfunction (CLAD). The pathogenesis of these allograft injuries, however, remains poorly understood. CXCL9 and CXCL10 are CXC chemokines induced by interferon-γ and act as potent chemoattractants of mononuclear cells. We hypothesized that these chemokines are involved in the mononuclear cell recruitment associated with AR and ALI. We further hypothesized that the increased activity of these chemokines could be quantified as increased levels in the bronchoalveolar lavage fluid. In this prospective multicenter study, we evaluate the incidence of histopathologic allograft injury development during the first-year post-transplant and measure bronchoalveolar CXCL9 and CXCL10 levels at the time of the biopsy. In multivariable models, CXCL9 levels were 1.7-fold and 2.1-fold higher during AR and ALI compared with "normal" biopsies without histopathology. Similarly, CXCL10 levels were 1.6-fold and 2.2-fold higher during these histopathologies, respectively. These findings support the association of CXCL9 and CXCL10 with episodes of AR and ALI and provide potential insight into the pathogenesis of these deleterious events.
(© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons.)
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معلومات مُعتمدة: UM2 AI117870 United States AI NIAID NIH HHS; U01 AI113315 United States AI NIAID NIH HHS; P01 HL108793 United States HL NHLBI NIH HHS; K23 HL138256 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: cytokines/cytokine receptors; immunobiology; lung disease: immune/inflammatory; lung failure/injury; lung transplantation/pulmonology; rejection: acute; translational research/science
المشرفين على المادة: 0 (Chemokine CXCL10)
0 (Chemokine CXCL9)
تواريخ الأحداث: Date Created: 20210411 Date Completed: 20211018 Latest Revision: 20230124
رمز التحديث: 20230126
مُعرف محوري في PubMed: PMC8502500
DOI: 10.1111/ajt.16601
PMID: 33840162
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-6143
DOI:10.1111/ajt.16601