دورية أكاديمية
Changes of Carotid Intima-Media Thickness After Sleeve Gastrectomy in High Cardiovascular Risk Patients: a Prospective Study.
العنوان: | Changes of Carotid Intima-Media Thickness After Sleeve Gastrectomy in High Cardiovascular Risk Patients: a Prospective Study. |
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المؤلفون: | Salman MA; General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Salman AA; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt. awea844@gmail.com., El Sherbiny M; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Elkholy S; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Youssef A; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Labib S; Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt., El-Din MT; General Surgery Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Monazea KA; General Surgery Department, Al-Azhar Faculty of Medicine for Boys - Assiut, Al-Azhar University, Assiut, Egypt., Tourky MS; Great Western Hospitals NHS Foundation Trust, Swindon, UK., Mikhail HMS; General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Maurice KK; General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Abdallah A; General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Mostafa MS; General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Hussein AM; General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Abdelsalam AM; General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Allah NA; Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Egypt., Ismaeel Saadawy AM; Radiology Department, Faculty of medicine, Ain-Shams University, Cairo, Egypt., Shaaban HE; Gastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt., Sarhan MD; General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt. |
المصدر: | Obesity surgery [Obes Surg] 2021 Aug; Vol. 31 (8), pp. 3541-3547. Date of Electronic Publication: 2021 Apr 12. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9106714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-0428 (Electronic) Linking ISSN: 09608923 NLM ISO Abbreviation: Obes Surg Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2006- : New York : Springer Science + Business Media Original Publication: Oxford, OX, UK : Rapid Communications of Oxford, [1991- |
مواضيع طبية MeSH: | Cardiovascular Diseases*/etiology , Laparoscopy* , Obesity, Morbid*/surgery, Carotid Intima-Media Thickness ; Egypt ; Gastrectomy ; Heart Disease Risk Factors ; Humans ; Prospective Studies ; Risk Factors |
مستخلص: | Purpose: There are insufficient data showing the impact of laparoscopic sleeve gastrectomy (LSG) on carotid intima-media thickness (CIMT). Therefore, in the current work, we investigated the improvement of metabolic syndrome and CIMT in patients with obesity after LSG. Methods: This study involved 120 consecutively selected Egyptian patients with a high cardiovascular risk who underwent LSG and were followed up for 12 months. Results: CIMT declined from 0.95 ± 0.17 mm to 0.83 ± 0.12 (p < 0.001) after 12 months. In addition, the mean fasting blood glucose and fasting inulin level dropped significantly from 153.3 ± 63.6 to 108.8 ± 33.8 mg/dl and from 23.1 ± 7.1 mU/ml to 14.1 ± 6.4 respectively (p < 0.001). Furthermore, glycated hemoglobin (HbA1c) declined from 7.02 ± 1.7 to 5.5 ± 0.96 (p < 0.001). At the end of the follow-up period, metabolic parameters such as HOMA-IR, C-reactive protein (CRP), fibrinogen, total cholesterol, LDL cholesterol, triglycerides, AST, and ALT decreased significantly from their respective baselines (p value < 0.001). Moreover, the reduction in CIMT showed a strong positive correlation with the degree of weight loss at 6 months and 12 months of follow-up. Conclusion: LSG led to a substantial decrease in CIMT. Moreover, it significantly impacted cardiovascular risk factors such as obesity, hypertension, insulin resistance, lipid profile, and inflammatory markers. (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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فهرسة مساهمة: | Keywords: Bariatric surgery; Carotid intima-media thickness; Laparoscopic sleeve gastrectomy; Metabolic syndrome |
تواريخ الأحداث: | Date Created: 20210412 Date Completed: 20210720 Latest Revision: 20211222 |
رمز التحديث: | 20221213 |
DOI: | 10.1007/s11695-021-05419-5 |
PMID: | 33844173 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1708-0428 |
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DOI: | 10.1007/s11695-021-05419-5 |