دورية أكاديمية
Network pharmacology study on the mechanism of the herb pair of prepared Rehmannia root-Chinese arborvitae kernel for anxiety disorders.
| العنوان: | Network pharmacology study on the mechanism of the herb pair of prepared Rehmannia root-Chinese arborvitae kernel for anxiety disorders. |
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| المؤلفون: | Liu PL; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China., Song AR; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China., Dong CD; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China., Chu Q; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China., Xu BL; College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China., Liu JM; Department of Psychosomatic Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China., Yan ZJ; Department of Psychosomatic Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China. 361257818@163.com. |
| المصدر: | Annals of palliative medicine [Ann Palliat Med] 2021 Mar; Vol. 10 (3), pp. 3313-3327. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: AME Publishing Company Country of Publication: China NLM ID: 101585484 Publication Model: Print Cited Medium: Internet ISSN: 2224-5839 (Electronic) Linking ISSN: 22245820 NLM ISO Abbreviation: Ann Palliat Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hong Kong : AME Publishing Company |
| مواضيع طبية MeSH: | Drugs, Chinese Herbal*/therapeutic use , Rehmannia* , Thuja*, Anxiety Disorders/drug therapy ; Anxiety Disorders/genetics ; China ; Humans ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Mas ; Serotonin Plasma Membrane Transport Proteins |
| مستخلص: | Background: Although anxiety disorders are one of the most common mental illness in population, antianxiety drugs often only have single action targets, require long-term use, and are associated with many adverse reactions and dependencies. Professor Yan Zhaojun from Shandong Provincial Hospital of Traditional Chinese Medicine (TCM) has applied the modified Renshu Powder, a TCM formula, to treat anxiety disorders, with satisfactory outcomes. Here, we investigated the mechanism of action of two core herbs (prepared Rehmannia root and Chinese arborvitae kernel) in the Renshu Powder in the treatment of anxiety disorders by using network pharmacology approaches. Methods: Candidate compounds of the herb pair of prepared Rehmannia root-Chinese arborvitae kernel were extracted via the Traditional Chinese Medicine Systems Pharmacology (TCMSP) platform. The targets of action of the main compounds were collected using the SwissTargetPrediction database. Targets associated with anxiety disorders were retrieved from DisGeNET, Online Mendelian Inheritance in Man (OMIM), DrugBank, GeneCards, and Comparative Toxicogenomics Database (CTD) databases. The compound-target interaction network was constructed by Cytoscape 3.7.2 software, and the protein-protein interaction (PPI) network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) platform. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses the data by using Metascape. Results: The main active compounds of the herb pair included arachidonic acid, stigmasterol, and beta-sitosterol. The key targets included Nitric Oxide Synthase 3 (NOS3), Epidermal growth factor (EGF), Prostaglandin-Endoperoxide Synthase 2 (PTGS2), Caspase 3 (CASP3), Mitogen-Activated Protein Kinase 1 (MAPK1), Peroxisome proliferator-activated receptor gamma (PPARG), RELA Proto-Oncogene, NF-KB Subunit (RELA), Estrogen Receptor 1 (ESR1), Solute Carrier Family 6 Member 4 (SLC6A4), and Phosphatase and Tensin homolog deleted on chromosome 10 (PTEN). Anxiety disorder-related GO analysis mainly involved synaptic signaling, neurotransmitter receptor activity, and G protein-coupled neurotransmitter receptor activity. The KEGG pathways involved neuroactive ligand-receptor interaction, serotonergic synapse, PI3K/AKT/mTOR signaling pathway, and MAPK signaling pathway. Conclusions: The mechanism of action of the prepared Rehmannia root-Chinese arborvitae kernel in treating anxiety disorders involves multiple ingredients, multiple targets, and pathways. |
| فهرسة مساهمة: | Keywords: Chinese arborvitae kernel; Prepared Rehmannia root; anxiety disorders; mechanism of action; network pharmacology |
| المشرفين على المادة: | 0 (Drugs, Chinese Herbal) 0 (MAS1 protein, human) 0 (Proto-Oncogene Mas) 0 (SLC6A4 protein, human) 0 (Serotonin Plasma Membrane Transport Proteins) |
| تواريخ الأحداث: | Date Created: 20210414 Date Completed: 20210514 Latest Revision: 20211204 |
| رمز التحديث: | 20231215 |
| DOI: | 10.21037/apm-21-531 |
| PMID: | 33849116 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2224-5839 |
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| DOI: | 10.21037/apm-21-531 |