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Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by Carissa carandas embedded silver nanoparticles in rodents.

التفاصيل البيبلوغرافية
العنوان: Amelioration of diethylnitrosamine (DEN) induced renal oxidative stress and inflammation by Carissa carandas embedded silver nanoparticles in rodents.
المؤلفون: Singh D; Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh, 211007, India., Chaudhary D; Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India., Kumar V; Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh, 211007, India., Verma A; Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad, Uttar Pradesh, 211007, India.
المصدر: Toxicology reports [Toxicol Rep] 2021 Mar 23; Vol. 8, pp. 636-645. Date of Electronic Publication: 2021 Mar 23 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ireland Ltd Country of Publication: Ireland NLM ID: 101630272 Publication Model: eCollection Cited Medium: Internet ISSN: 2214-7500 (Electronic) Linking ISSN: 22147500 NLM ISO Abbreviation: Toxicol Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Ireland] : Elsevier Ireland Ltd., [2014]-
مستخلص: Introduction: Inflammation and oxidative stress are the main factors ascribed with interruption in the process of renal tissue impairment. The toxicity of different types of nitrosamine is well recognized in animals and humans. Administration of the smallest quantities of diethylnitrosamine or dimethylnitrosamine either orally or parenterally results into renal damage. Therapeutic effects of phytofabricated silver nanoparticles of Carissa carandas aqueous extract has been scrutinised in current study for the assessment of renal cancer activity in animal model.
Methodology: Phytofabricated silver nanoparticles were characterized by using different instrumentation. Nephroprotective activity of silver nanoparticles at different doses was evaluated against N-diethylnitrosamine (200 mg/kg b.w., intraperitoneal) in animal model. Serum and renal homogenate were taken to evaluate the renal toxicity markers, oxidative stress, and antioxidant parameter, proinflammatory cytokines and histopathological study.
Result: Significant outcomes of silver nanoparticles in dose dependent manner down regulated the elevated serum marker, tumour marker enzymes and histopathology observation of repaired tissue assured the renal cancer activity in animals. In addition, profile of enzymatic and non-enzymatic antioxidant, proinflammatory cytokines and tumour promotion marker also favours the anticancer property of silver nanoparticles.
Conclusion: The data of current study reveals silver nanoparticles ameliorates renal oxidative stress and carcinogenesis which was induced by N-diethylnitrosamine and accredited to antioxidant and anticancer activities of phytofabricated nanoparticles by biological approach.
Competing Interests: The authors declare no conflict of interest.
(© 2021 Published by Elsevier B.V.)
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فهرسة مساهمة: Keywords: ABTS, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid; AgNO3, silver nitrate; AgNPs, silver nanoparticles; BUN, blood urea nitrogen; CC, carissa carandas; CCAgNPs, silver nanoparticles of carissa carandas aqueous extract; CDNB, 1-chloro-2,4-dinitrobenzene; Carissa carandas embedded silver nanoparticles; DEN, diethylnitrosamine; DLS, dynamic light scattering; DMN, dimethylnitrosamine; DMSO, dimethyl sulphoxide; FE-SEM, field emission scanning electron microscopy; GGT, gamma glutamyl transpeptidase; GGT, γ-glutamyl transpeptidase activity; GPx, glutathione peroxidase; GR, glutathione reductase activity; GSH, glutathione; GST, glutathione –S- Transferase; H2O2, hydrogen peroxide; IAEC, institutional animal ethical committee; LDH, lactate dehydrogenase; MDA, malondialdehyde; NF-κB pathway; NPs, nanoparticles; ODC, ornithine decarboxylase; ROS, reactive oxygen species; Renal carcinoma; SOD, superoxide dismutase; XO, xanthine oxidase
تواريخ الأحداث: Date Created: 20210414 Latest Revision: 20240809
رمز التحديث: 20240809
مُعرف محوري في PubMed: PMC8039534
DOI: 10.1016/j.toxrep.2021.03.014
PMID: 33850732
قاعدة البيانات: MEDLINE
الوصف
تدمد:2214-7500
DOI:10.1016/j.toxrep.2021.03.014