دورية أكاديمية
أعرض في EDS

Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs.

التفاصيل البيبلوغرافية
العنوان: Interacting impact of maternal inflammatory response and stress on the amygdala transcriptome of pigs.
المؤلفون: Keever-Keigher MR; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Zhang P; Illinois Informatics Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Bolt CR; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Rymut HE; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Antonson AM; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Caputo MP; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Houser AK; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Hernandez AG; High-Throughput Sequencing and Genotyping Unit, Roy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Southey BR; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Rund LA; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Johnson RW; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA., Rodriguez-Zas SL; Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.; Illinois Informatics Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.; Department of Statistics, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61820, USA.
المصدر: G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 Aug 07; Vol. 11 (8).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101566598 Publication Model: Print Cited Medium: Internet ISSN: 2160-1836 (Electronic) Linking ISSN: 21601836 NLM ISO Abbreviation: G3 (Bethesda) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [Oxford] : Oxford University Press
Original Publication: Bethesda, MD : Genetics Society of America, 2011-
مواضيع طبية MeSH: Prenatal Exposure Delayed Effects*, Amygdala ; Animals ; Behavior, Animal ; Female ; Inflammation/genetics ; Male ; Poly I-C ; Swine ; Transcriptome
مستخلص: Changes at the molecular level capacitate the plasticity displayed by the brain in response to stress stimuli. Weaning stress can trigger molecular changes that influence the physiology of the offspring. Likewise, maternal immune activation (MIA) during gestation has been associated with behavior disorders and molecular changes in the amygdala of the offspring. This study advances the understanding of the effects of pre- and postnatal stressors in amygdala gene networks. The amygdala transcriptome was profiled on female and male pigs that were either exposed to viral-elicited MIA or not and were weaned or nursed. Overall, 111 genes presented interacting or independent effects of weaning, MIA, or sex (FDR-adjusted P-value <0.05). PIGY upstream reading frame and orthodenticle homeobox 2 are genes associated with MIA-related neurological disorders, and presented significant under-expression in weaned relative to nursed pigs exposed to MIA, with a moderate pattern observed in non-MIA pigs. Enriched among the genes presenting highly over- or under-expression profiles were 24 Kyoto Encyclopedia of Genes and Genomes pathways including inflammation, and neurological disorders. Our results indicate that MIA and sex can modulate the effect of weaning stress on the molecular mechanisms in the developing brain. Our findings can help identify molecular targets to ameliorate the effects of pre- and postnatal stressors on behaviors regulated by the amygdala such as aggression and feeding.
(© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.)
References: Nat Biotechnol. 2016 May;34(5):525-7. (PMID: 27043002)
Psychopharmacology (Berl). 2019 Jul;236(7):2119-2142. (PMID: 30900007)
Brain Behav Immun. 2017 Jan;59:300-312. (PMID: 27650113)
Appl Anim Behav Sci. 2000 Nov 1;70(1):41-48. (PMID: 10986422)
Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20190-20200. (PMID: 31527230)
Schizophr Res. 1992 Mar;6(3):181-92. (PMID: 1571312)
Curr Genomics. 2010 Sep;11(6):447-69. (PMID: 21358990)
Psychoneuroendocrinology. 2009 Nov;34(10):1515-25. (PMID: 19524372)
J Neuropathol Exp Neurol. 2007 Jun;66(6):552-61. (PMID: 17549015)
Science. 2013 Mar 1;339(6123):1095-9. (PMID: 23449593)
J Anim Sci Biotechnol. 2013 Apr 30;4(1):19. (PMID: 23631414)
Mol Neurobiol. 2017 Nov;54(9):7019-7027. (PMID: 27796743)
Brain Behav Immun. 1995 Mar;9(1):9-19. (PMID: 7542507)
Neuroscience. 2011 May 19;182:43-61. (PMID: 21396433)
Neurochem Int. 2019 Jun;126:36-58. (PMID: 30862493)
Brain Res. 1998 Sep 7;804(2):311-5. (PMID: 9757073)
Pediatr Res. 2005 Jul;58(1):112-6. (PMID: 15879289)
PLoS One. 2011;6(9):e24723. (PMID: 21935445)
Eur J Neurosci. 2017 Oct;46(7):2241-2252. (PMID: 28612962)
Nucleic Acids Res. 2007 Jan;35(Database issue):D61-5. (PMID: 17130148)
Dev Neurosci. 2018;40(2):104-119. (PMID: 29539630)
Schizophr Bull. 2001;27(3):457-76. (PMID: 11596847)
Nucleic Acids Res. 2019 Jul 2;47(W1):W199-W205. (PMID: 31114916)
PLoS Comput Biol. 2014 Jul 24;10(7):e1003731. (PMID: 25058159)
Brain Behav Immun. 2020 Oct;89:100-117. (PMID: 32485291)
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3543-8. (PMID: 19202080)
Front Mol Neurosci. 2016 Jan 11;8:84. (PMID: 26793054)
Behav Brain Res. 2011 Oct 10;224(1):180-8. (PMID: 21679729)
Mol Cell Biol. 2011 Jul;31(14):2838-44. (PMID: 21576365)
Nature. 2000 Feb 24;403(6772):909-13. (PMID: 10706291)
Neuroscience. 2014 Jan 31;258:147-61. (PMID: 24240029)
J Nutr. 2004 Mar;134(3):641-7. (PMID: 14988461)
Brain Res. 2006 Jan 5;1067(1):36-42. (PMID: 16271354)
Am J Psychiatry. 2006 Mar;163(3):521-8. (PMID: 16513876)
Nat Genet. 2000 May;25(1):25-9. (PMID: 10802651)
Behav Brain Res. 2010 Jul 11;210(2):280-3. (PMID: 20219557)
Front Behav Neurosci. 2018 Apr 03;12:64. (PMID: 29666573)
Semin Immunol. 2014 Oct;26(5):380-8. (PMID: 24882055)
Trends Genet. 2016 Mar;32(3):139-146. (PMID: 26830258)
Genome Res. 2003 Nov;13(11):2498-504. (PMID: 14597658)
Brain Behav Immun. 2015 Jan;43:159-71. (PMID: 25108214)
Physiol Genomics. 2015 May;47(5):170-6. (PMID: 25716693)
Brain Behav Immun. 2014 May;38:237-48. (PMID: 24561490)
Dev Neurosci. 2009;31(4):318-31. (PMID: 19546569)
Neurosci Biobehav Rev. 2014 Jan;38:72-93. (PMID: 24247023)
Trends Mol Med. 2016 Oct;22(10):877-888. (PMID: 27614925)
Bioinformatics. 2010 Jan 1;26(1):139-40. (PMID: 19910308)
Nat Rev Neurol. 2014 Nov;10(11):643-60. (PMID: 25311587)
Eur J Neurosci. 2001 Mar;13(6):1101-6. (PMID: 11285007)
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. (PMID: 30476243)
J Anim Sci. 2012 Feb;90(2):649-56. (PMID: 21926316)
Behav Brain Res. 2006 Oct 2;173(1):129-37. (PMID: 16860405)
J Anim Sci Biotechnol. 2017 Jan 28;8:14. (PMID: 28149513)
Neuroscience. 2012 Sep 18;220:90-9. (PMID: 22732504)
J Psychiatr Res. 1999 Nov-Dec;33(6):543-8. (PMID: 10628531)
Protein Sci. 2019 Nov;28(11):1947-1951. (PMID: 31441146)
J Neurophysiol. 2019 Sep 1;122(3):1002-1022. (PMID: 31268807)
Epigenetics. 2012 Apr;7(4):409-14. (PMID: 22419064)
Mol Psychiatry. 2016 Jul;21(7):956-68. (PMID: 26830140)
Sci Rep. 2017 Nov 2;7(1):14886. (PMID: 29097775)
Transl Psychiatry. 2017 May 9;7(5):e1120. (PMID: 28485733)
Nucleic Acids Res. 2019 Jan 8;47(D1):D330-D338. (PMID: 30395331)
Stress. 2019 Sep;22(5):563-570. (PMID: 31007117)
Nucleic Acids Res. 2000 Jan 1;28(1):27-30. (PMID: 10592173)
Toxicology. 2015 Dec 2;338:95-103. (PMID: 26524701)
Behav Brain Res. 2010 Sep 1;212(1):64-70. (PMID: 20382186)
Brief Bioinform. 2019 Jul 19;20(4):1085-1093. (PMID: 29447345)
Brain Res Bull. 1999 May;49(1-2):1-137. (PMID: 10466025)
Mol Psychiatry. 2018 Apr;23(4):1001-1013. (PMID: 28322282)
Science. 2017 Jun 16;356(6343):1185-1188. (PMID: 28619944)
Front Neurosci. 2020 Aug 11;14:774. (PMID: 32848554)
J Reprod Immunol. 2018 Apr;126:18-22. (PMID: 29421625)
معلومات مُعتمدة: P30 DA018310 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: RNA-seq; double-hit hypothesis; gestational stress; weaning stress
المشرفين على المادة: O84C90HH2L (Poly I-C)
تواريخ الأحداث: Date Created: 20210415 Date Completed: 20220105 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC8496236
DOI: 10.1093/g3journal/jkab113
PMID: 33856433
قاعدة البيانات: MEDLINE
الوصف
تدمد:2160-1836
DOI:10.1093/g3journal/jkab113