دورية أكاديمية
Nanoemulsion Improves the Neuroprotective Effects of Curcumin in an Experimental Model of Parkinson's Disease.
| العنوان: | Nanoemulsion Improves the Neuroprotective Effects of Curcumin in an Experimental Model of Parkinson's Disease. |
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| المؤلفون: | Ramires Júnior OV; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Campus Saúde, Universidade Federal do Rio Grande, Rua Visconde de Paranaguá, 102, Centro, Rio Grande, RS, 96203-900, Brazil., Alves BDS; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Campus Saúde, Universidade Federal do Rio Grande, Rua Visconde de Paranaguá, 102, Centro, Rio Grande, RS, 96203-900, Brazil., Barros PAB; Instituto de Ciências Biológicas, Campus Carreiros, Universidade Federal do Rio Grande, Av. Itália, km 8, Rio Grande, RS, 96203-900, Brazil., Rodrigues JL; Instituto de Ciências Biológicas, Campus Carreiros, Universidade Federal do Rio Grande, Av. Itália, km 8, Rio Grande, RS, 96203-900, Brazil., Ferreira SP; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Campus Saúde, Universidade Federal do Rio Grande, Rua Visconde de Paranaguá, 102, Centro, Rio Grande, RS, 96203-900, Brazil., Monteiro LKS; Instituto de Ciências Biológicas, Campus Carreiros, Universidade Federal do Rio Grande, Av. Itália, km 8, Rio Grande, RS, 96203-900, Brazil., Araújo GMS; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Campus Saúde, Universidade Federal do Rio Grande, Rua Visconde de Paranaguá, 102, Centro, Rio Grande, RS, 96203-900, Brazil., Fernandes SS; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Campus Saúde, Universidade Federal do Rio Grande, Rua Visconde de Paranaguá, 102, Centro, Rio Grande, RS, 96203-900, Brazil., Vaz GR; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Campus Saúde, Universidade Federal do Rio Grande, Rua Visconde de Paranaguá, 102, Centro, Rio Grande, RS, 96203-900, Brazil., Dora CL; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Campus Saúde, Universidade Federal do Rio Grande, Rua Visconde de Paranaguá, 102, Centro, Rio Grande, RS, 96203-900, Brazil.; Instituto de Ciências Biológicas, Campus Carreiros, Universidade Federal do Rio Grande, Av. Itália, km 8, Rio Grande, RS, 96203-900, Brazil., Hort MA; Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Campus Saúde, Universidade Federal do Rio Grande, Rua Visconde de Paranaguá, 102, Centro, Rio Grande, RS, 96203-900, Brazil. marianaappel@gmail.com.; Instituto de Ciências Biológicas, Campus Carreiros, Universidade Federal do Rio Grande, Av. Itália, km 8, Rio Grande, RS, 96203-900, Brazil. marianaappel@gmail.com. |
| المصدر: | Neurotoxicity research [Neurotox Res] 2021 Jun; Vol. 39 (3), pp. 787-799. Date of Electronic Publication: 2021 Apr 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 100929017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-3524 (Electronic) Linking ISSN: 10298428 NLM ISO Abbreviation: Neurotox Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2009-> : New York : Springer Original Publication: [Amsterdam?] : Harwood Academic Publishers, |
| مواضيع طبية MeSH: | Curcumin/*administration & dosage , Emulsions/*administration & dosage , Nanoparticles/*administration & dosage , Neuroprotective Agents/*administration & dosage , Parkinsonian Disorders/*prevention & control , Rotenone/*toxicity, Animals ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Curcumin/chemistry ; Emulsions/chemistry ; Male ; Mice ; Nanoparticles/chemistry ; Neuroprotective Agents/chemistry ; Parkinsonian Disorders/chemically induced ; Parkinsonian Disorders/metabolism |
| مستخلص: | Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. Recent studies have shown that curcumin (CUR) has neuroprotective effects in PD experimental models. However, its efficacy is limited due to low water solubility, bioavailability, and access to the central nervous system. In this study, we compared the effects of new curcumin-loaded nanoemulsions (NC) and free CUR in an experimental model of PD. Adult Swiss mice received NC or CUR (25 and 50 mg/kg) or vehicle orally for 30 days. Starting on the eighth day, they were administered rotenone (1 mg/kg) intraperitoneally until the 30th day. At the end of the treatment, motor assessment was evaluated by open field, pole test, and beam walking tests. Oxidative stress markers and mitochondrial complex I activity were measured in the brain tissue. Both NC and CUR treatment significantly improved motor impairment, reduced lipoperoxidation, modified antioxidant defenses, and prevented inhibition of complex I. However, NC was more effective in preventing motor impairment and inhibition of complex I when compared to CUR in the free form. In conclusion, our results suggest that NC effectively enhances the neuroprotective potential of CUR and is a promising nanomedical application for PD. |
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| معلومات مُعتمدة: | 449650/2014-6 Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| فهرسة مساهمة: | Keywords: Curcumin; Motor impairment; Nanoparticles; Oxidative stress; Parkinson’s disease |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Emulsions) 0 (Neuroprotective Agents) 03L9OT429T (Rotenone) IT942ZTH98 (Curcumin) |
| تواريخ الأحداث: | Date Created: 20210416 Date Completed: 20211129 Latest Revision: 20221021 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s12640-021-00362-w |
| PMID: | 33860897 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1476-3524 |
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| DOI: | 10.1007/s12640-021-00362-w |