دورية أكاديمية
أعرض في EDS

Short report: Introduction of chikungunya virus ECSA genotype into the Brazilian Midwest and its dispersion through the Americas.

التفاصيل البيبلوغرافية
العنوان: Short report: Introduction of chikungunya virus ECSA genotype into the Brazilian Midwest and its dispersion through the Americas.
المؤلفون: de Oliveira EC; Laboratório Central de Saúde Pública do Estado de Mato Grosso, Cuiabá, Brazil., Fonseca V; Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZuluNatal, Durban 4001, South Africa.; Coordenação Geral dos Laboratórios de Saúde Pública/Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasília, Distrito Federal, Brazil., Xavier J; Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Adelino T; Laboratório Central de Saúde Pública, Fundação Ezequiel Dias, Belo Horizonte, Brazil., Morales Claro I; Instituto de Medicina Tropical e Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Fabri A; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Marques Macario E; Secretaria de Vigilância em Saúde/Ministério da Saúde, Brasília, Distrito Federal, Brazil., Viniski AE; Laboratório Central de Saúde Pública do Estado de Mato Grosso, Cuiabá, Brazil., Campos Souza CL; Laboratório Central de Saúde Pública do Estado de Mato Grosso, Cuiabá, Brazil., Gomes da Costa ES; Secretaria de Saúde de Cuiaba, Mato Grosso, Brazil., Soares de Sousa C; Secretaria de Saúde de Cuiaba, Mato Grosso, Brazil., Guimarães Dias Duarte F; Secretaria de Saúde de Cuiaba, Mato Grosso, Brazil., Correia de Medeiros A; Secretaria de Vigilância em Saúde/Ministério da Saúde, Brasília, Distrito Federal, Brazil., Campelo de Albuquerque CF; Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília-DF, Brazil., Venancio Cunha R; Fundação Oswaldo Cruz, Bio-Manguinhos, Rio de Janeiro, Brasil., Oliveira De Moura NF; Coordenacao Geral das Arboviroses, Secretaria de Vigilância em Saúde/Ministério da Saúde, Brasília, Distrito Federal, Brazil., Bispo de Filippis AM; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Oliveira T; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZuluNatal, Durban 4001, South Africa., Lourenço J; Department of Zoology, University of Oxford, Oxford, OX1 3PS, United Kingdom., de Abreu AL; Coordenação Geral dos Laboratórios de Saúde Pública/Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasília, Distrito Federal, Brazil., Alcantara LCJ; Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Giovanetti M; Laboratório de Genética Celular e Molecular, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Apr 16; Vol. 15 (4), pp. e0009290. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Chikungunya Fever/*epidemiology , Chikungunya Fever/*transmission , Chikungunya virus/*genetics , Genome, Viral/*genetics, Adolescent ; Adult ; Bayes Theorem ; Brazil/epidemiology ; Chikungunya Fever/diagnosis ; Chikungunya virus/isolation & purification ; Epidemiological Monitoring ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Phylogeny ; Spatio-Temporal Analysis ; Whole Genome Sequencing ; Young Adult
مستخلص: Since introduction into Brazil in 2014, chikungunya virus (CHIKV) has presented sustained transmission, although much is unknown about its circulation in the midwestern states. Here, we analyze 24 novel partial and near complete CHIKV genomes from Cuiaba, an urban metropolis located in the Brazilian midwestern state of Mato Grosso (MT). Nanopore technology was used for sequencing CHIKV complete genomes. Phylogenetic and epidemiological approaches were used to explore the recent spatio-temporal evolution and spread of the CHIKV-ECSA genotype in Midwest Brazil as well as in the Americas. Epidemiological data revealed a reduction in the number of reported cases over 2018-2020, likely as a consequence of a gradual accumulation of herd-immunity. Phylogeographic reconstructions revealed that at least two independent introductions of the ECSA lineage occurred in MT from a dispersion event originating in the northeastern region and suggest that the midwestern Brazilian region appears to have acted as a source of virus transmission towards Paraguay, a bordering South American country. Our results show a complex dynamic of transmission between epidemic seasons and suggest a possible role of Brazil as a source for international dispersion of the CHIKV-ECSA genotype to other countries in the Americas.
Competing Interests: The authors have declared that no competing interests exist.
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تواريخ الأحداث: Date Created: 20210416 Date Completed: 20210729 Latest Revision: 20231111
رمز التحديث: 20231111
مُعرف محوري في PubMed: PMC8051810
DOI: 10.1371/journal.pntd.0009290
PMID: 33861753
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0009290