دورية أكاديمية
أعرض في EDS

Effect of maternal praziquantel treatment for Schistosoma japonicum infection on the offspring susceptibility and immunologic response to infection at age six, a cohort study.

التفاصيل البيبلوغرافية
العنوان: Effect of maternal praziquantel treatment for Schistosoma japonicum infection on the offspring susceptibility and immunologic response to infection at age six, a cohort study.
المؤلفون: Colt S; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.; Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America., Jarilla B; Research Institute for Tropical Medicine, Manila, The Philippines., Baltazar P; Research Institute for Tropical Medicine, Manila, The Philippines.; Remedios Trinidad Romualdez Hospital, Tacloban City, Leyte, The Philippines., Tallo V; Research Institute for Tropical Medicine, Manila, The Philippines., Acosta LP; Research Institute for Tropical Medicine, Manila, The Philippines., Wu HW; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.; Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America., Barry CV; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America., Kurtis JD; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.; Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America., Olveda RM; Research Institute for Tropical Medicine, Manila, The Philippines., Friedman JF; Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America.; Department of Pediatrics, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America., Jiz MA; Research Institute for Tropical Medicine, Manila, The Philippines.
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Apr 16; Vol. 15 (4), pp. e0009328. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).
نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Immunity, Maternally-Acquired*, Cytokines/*metabolism , Praziquantel/*administration & dosage , Pregnancy Complications, Parasitic/*drug therapy , Schistosomiasis japonica/*drug therapy, Animals ; Antiprotozoal Agents/administration & dosage ; Child ; Cohort Studies ; Cytokines/blood ; Double-Blind Method ; Female ; Humans ; Leukocytes, Mononuclear/immunology ; Linear Models ; Male ; Multivariate Analysis ; Philippines ; Pregnancy ; Pregnancy Complications, Parasitic/immunology ; Schistosoma japonicum/drug effects ; Schistosomiasis japonica/immunology ; Treatment Outcome
مستخلص: In areas endemic to schistosomiasis, fetal exposure to schistosome antigens prime the offspring before potential natural infection. Praziquantel (PZQ) treatment for Schistosoma japonicum infection in pregnant women has been demonstrated to be safe and effective. Our objectives were to evaluate whether maternal PZQ treatment modifies the process of in utero sensitization to schistosome antigens potentially impacting later risk of infection, as well as immune response to S. japonicum. We enrolled 295 children at age six, born to mothers with S. japonicum infection who participated in a randomized control trial of PZQ versus placebo given at 12-16 weeks gestation in Leyte, The Philippines. At enrollment, we assessed and treated current S. japonicum infection and measured serum cytokines. During a follow-up visit four weeks later, we assessed peripheral blood mononuclear cell (PBMC) cytokine production in response to soluble worm antigen preparation (SWAP) or soluble egg antigen (SEA). Associations between maternal treatment group and the child's S. japonicum infection status and immunologic responses were determined using multivariate linear regression analysis. PZQ treatment during pregnancy did not impact the prevalence (P = 0.12) or intensity (P = 0.59) of natural S. japonicum infection among children at age six. Among children with infection at enrollment (12.5%) there were no significant serum cytokine concentration differences between maternal treatment groups. Among children with infection at enrollment, IL-1 production by PBMCs stimulated with SEA was higher (P = 0.03) in the maternal PZQ group compared to placebo. Among children without infection, PBMCs stimulated with SEA produced greater IL-12 (P = 0.03) and with SWAP produced less IL-4 (P = 0.01) in the maternal PZQ group compared to placebo. Several cytokines produced by PBMCs in response to SWAP and SEA were significantly higher in children with S. japonicum infection irrespective of maternal treatment: IL-4, IL-5, IL-10, and IL-13. We report that maternal PZQ treatment for S. japonicum shifted the PBMC immune response to a more inflammatory signature but had no impact on their offspring's likelihood of infection or serum cytokines at age six, further supporting the safe use of PZQ in pregnant women. Trial Registration: ClinicalTrials.gov NCT00486863.
Competing Interests: The authors have declared that no competing interests exist. Author Remigio M. Olveda was unable to confirm their authorship contributions. On their behalf, the corresponding author has reported their contributions to the best of their knowledge
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معلومات مُعتمدة: K24 AI112964 United States AI NIAID NIH HHS; P50 AI098481 United States AI NIAID NIH HHS; U01 AI066050 United States AI NIAID NIH HHS
سلسلة جزيئية: ClinicalTrials.gov NCT00486863
المشرفين على المادة: 0 (Antiprotozoal Agents)
0 (Cytokines)
6490C9U457 (Praziquantel)
تواريخ الأحداث: Date Created: 20210416 Date Completed: 20210727 Latest Revision: 20230118
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8081342
DOI: 10.1371/journal.pntd.0009328
PMID: 33861768
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0009328