دورية أكاديمية
أعرض في EDS

Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure.

التفاصيل البيبلوغرافية
العنوان: Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure.
المؤلفون: Hrubec TC; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA.; Department of Biomedical Science and Pathobiology, VA-MD College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, 24061, USA., Seguin RP; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, 98195, USA., Xu L; Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA, 98195, USA., Cortopassi GA; Department of Molecular Biosciences, School of Veterinary Medicine, University of California - Davis, Davis, CA, 95618, USA., Datta S; Department of Molecular Biosciences, School of Veterinary Medicine, University of California - Davis, Davis, CA, 95618, USA., Hanlon AL; Center for Biostatistics and Health Data Science, Department of Statistics, College of Science, Virginia Tech, Riverside Circle, Roanoke, VA, 24016, USA., Lozano AJ; Center for Biostatistics and Health Data Science, Department of Statistics, College of Science, Virginia Tech, Riverside Circle, Roanoke, VA, 24016, USA., McDonald VA; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA., Healy CA; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA., Anderson TC; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA., Musse NA; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA., Williams RT; Department of Biomedical Science, E. Via College of Osteopathic Medicine - Virginia, Blacksburg, VA, 24060, USA.
المصدر: Toxicology reports [Toxicol Rep] 2021 Mar 09; Vol. 8, pp. 646-656. Date of Electronic Publication: 2021 Mar 09 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ireland Ltd Country of Publication: Ireland NLM ID: 101630272 Publication Model: eCollection Cited Medium: Internet ISSN: 2214-7500 (Electronic) Linking ISSN: 22147500 NLM ISO Abbreviation: Toxicol Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Ireland] : Elsevier Ireland Ltd., [2014]-
مستخلص: Humans are frequently exposed to Quaternary Ammonium Compounds (QACs). QACs are ubiquitously used in medical settings, restaurants, and homes as cleaners and disinfectants. Despite their prevalence, nothing is known about the health effects associated with chronic low-level exposure. Chronic QAC toxicity, only recently identified in mice, resulted in developmental, reproductive, and immune dysfunction. Cell based studies indicate increased inflammation, decreased mitochondrial function, and disruption of cholesterol synthesis. If these findings translate to human toxicity, multiple physiological processes could be affected. This study tested whether QAC concentrations could be detected in the blood of 43 human volunteers, and whether QAC concentrations influenced markers of inflammation, mitochondrial function, and cholesterol synthesis. QAC concentrations were detected in 80 % of study participants. Blood QACs were associated with increase in inflammatory cytokines, decreased mitochondrial function, and disruption of cholesterol homeostasis in a dose dependent manner. This is the first study to measure QACs in human blood, and also the first to demonstrate statistically significant relationships between blood QAC and meaningful health related biomarkers. Additionally, the results are timely in light of the increased QAC disinfectant exposure occurring due to the SARS-CoV-2 pandemic.
Main Findings: This study found that 80 % of study participants contained QACs in their blood; and that markers of inflammation, mitochondrial function, and sterol homeostasis varied with blood QAC concentration.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2021 The Authors.)
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معلومات مُعتمدة: P30 ES023513 United States ES NIEHS NIH HHS; UL1 TR003015 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: 7-DHC, 7-Dehydrocholesterol; 7-DHD, 7-Dehydrodesmosterol; 8-DHC, 8-Dehydrocholesterol; ADBAC, alkyldimethylbenzyl ammonium chloride; ANOVA, analysis of variance; BAC, benzalkonium chloride; CRP, C-reactive protein; DDAC, didecyldimethyl ammonium chloride; Environmental toxicology; FCCP, trifluoromethoxy carbonylcyanide phenylhydrazone; IL-10, interleukin 10; IL-12, interleukin 12; IL-6, interleukin 6; IRB, Institutional Review Board; Inflammation; LC, liquid chromatography; LOD, level of detection; LOQ, level of quantification; LPS, lipopolysaccharide; Lipid metabolism; Mitochondrial function; NF-κB, nuclear factor kappa beta; NOEL, no effect level; OCR, oxygen consumption rate; OEL, occupational exposure limit; QAC, quaternary ammonium compounds; Quaternary ammonium compounds; TNFα, tumor necrosis factor alpha
تواريخ الأحداث: Date Created: 20210419 Latest Revision: 20240331
رمز التحديث: 20240331
مُعرف محوري في PubMed: PMC8041661
DOI: 10.1016/j.toxrep.2021.03.006
PMID: 33868951
قاعدة البيانات: MEDLINE
الوصف
تدمد:2214-7500
DOI:10.1016/j.toxrep.2021.03.006