دورية أكاديمية
Synthesis and biological evaluation of new coumarin derivatives as cytotoxic agents.
العنوان: | Synthesis and biological evaluation of new coumarin derivatives as cytotoxic agents. |
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المؤلفون: | Ragab FA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Eissa AAM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Fahim SH; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Salem MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt.; School of Life and Medical Sciences, University of Hertfordshire hosted by Global Academic Foundation, Cairo, Egypt., Gamal MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Nissan YM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza, Egypt. |
المصدر: | Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Aug; Vol. 354 (8), pp. e2100029. Date of Electronic Publication: 2021 Apr 19. |
نوع المنشور: | Comparative Study; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2005->: Weinheim Germany : Wiley-VCH Verlag GmbH & Co. KGaA Original Publication: Weinheim, Verlag Chemie GmbH. |
مواضيع طبية MeSH: | Antineoplastic Agents/*pharmacology , Breast Neoplasms/*drug therapy , Coumarins/*pharmacology , Neoplasms/*drug therapy, A549 Cells ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Breast Neoplasms/pathology ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Doxorubicin/pharmacology ; ErbB Receptors/genetics ; Erlotinib Hydrochloride/pharmacology ; HCT116 Cells ; Hep G2 Cells ; Humans ; Inhibitory Concentration 50 ; MCF-7 Cells ; Molecular Docking Simulation ; Neoplasms/genetics ; Neoplasms/pathology ; Solubility ; Structure-Activity Relationship |
مستخلص: | New coumarin derivatives 9a-f, 10a-e, and 11a-f were synthesized and evaluated for their cytotoxic activity against a human breast cancer cell line (MCF-7). All compounds exhibited good activity in the nanomolar range, using doxorubicin and erlotinib as positive controls. The most active compound 9d with IC (© 2021 Deutsche Pharmazeutische Gesellschaft.) |
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فهرسة مساهمة: | Keywords: EGFR; MCF-7; anticancer activity; coumarin; pyrazoline |
المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Coumarins) 80168379AG (Doxorubicin) DA87705X9K (Erlotinib Hydrochloride) EC 2.7.10.1 (EGFR protein, human) EC 2.7.10.1 (ErbB Receptors) |
تواريخ الأحداث: | Date Created: 20210419 Date Completed: 20211230 Latest Revision: 20211230 |
رمز التحديث: | 20240628 |
DOI: | 10.1002/ardp.202100029 |
PMID: | 33872414 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1521-4184 |
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DOI: | 10.1002/ardp.202100029 |