دورية أكاديمية
A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation.
| العنوان: | A leukotriene-dependent spleen-liver axis drives TNF production in systemic inflammation. |
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| المؤلفون: | Fonseca MT; Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508, Brazil., Moretti EH; Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508, Brazil., Marques LMM; NPPNS, Departamento de Fisica e Quimica, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP 14040, Brazil., Machado BF; Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508, Brazil., Brito CF; Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508, Brazil., Guedes JT; Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508, Brazil., Komegae EN; Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508, Brazil., Vieira TS; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508, Brazil., Festuccia WT; Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508, Brazil., Lopes NP; NPPNS, Departamento de Fisica e Quimica, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP 14040, Brazil., Steiner AA; Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP 05508, Brazil. asteiner@usp.br. |
| المصدر: | Science signaling [Sci Signal] 2021 Apr 20; Vol. 14 (679). Date of Electronic Publication: 2021 Apr 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Association for the Advancement of Science |
| مواضيع طبية MeSH: | Leukotriene B4* , Spleen*, Animals ; Inflammation ; Lipopolysaccharides/toxicity ; Liver ; Rats ; Tumor Necrosis Factor-alpha |
| مستخلص: | Production of the proinflammatory cytokine tumor necrosis factor (TNF) must be precisely regulated for effective host immunity without the induction of collateral tissue damage. Here, we showed that TNF production was driven by a spleen-liver axis in a rat model of systemic inflammation induced by bacterial lipopolysaccharide (LPS). Analysis of cytokine expression and secretion in combination with splenectomy and hepatectomy revealed that the spleen generated not only TNF but also factors that enhanced TNF production by the liver, the latter of which accounted for nearly half of the TNF secreted into the circulation. Using mass spectrometry-based lipidomics, we identified leukotriene B (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.) |
| المشرفين على المادة: | 0 (Lipopolysaccharides) 0 (Tumor Necrosis Factor-alpha) 1HGW4DR56D (Leukotriene B4) |
| تواريخ الأحداث: | Date Created: 20210421 Date Completed: 20220113 Latest Revision: 20220113 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1126/scisignal.abb0969 |
| PMID: | 33879603 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1937-9145 |
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| DOI: | 10.1126/scisignal.abb0969 |