Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus.
| العنوان: | Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus. |
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| المؤلفون: | Kasela S; New York Genome Center, New York, NY, USA.; Department of Systems Biology, Columbia University, New York, NY, USA., Daniloski Z; New York Genome Center, New York, NY, USA.; Department of Biology, New York University, New York, NY, USA., Jordan TX; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., tenOever BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sanjana NE; New York Genome Center, New York, NY, USA.; Department of Biology, New York University, New York, NY, USA., Lappalainen T; New York Genome Center, New York, NY, USA.; Department of Biology, New York University, New York, NY, USA. |
| المصدر: | MedRxiv : the preprint server for health sciences [medRxiv] 2021 Apr 13. Date of Electronic Publication: 2021 Apr 13. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | To date the locus with the most robust human genetic association to COVID-19 susceptibility is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that mediate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology. Competing Interests: Competing interests N.E.S. is an advisor to Vertex. T.L. advises and has equity in Variant Bio, and is a member of the scientific advisory board of Goldfinch Bio. The remaining authors declare that they have no competing interests. |
| التعليقات: | Update in: Genome Biol. 2021 Aug 23;22(1):242. (PMID: 34425859) |
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| معلومات مُعتمدة: | R01 MH106842 United States MH NIMH NIH HHS; R01 CA218668 United States CA NCI NIH HHS; R01 AI123155 United States AI NIAID NIH HHS; UM1 HG008901 United States HG NHGRI NIH HHS; DP2 HG010099 United States HG NHGRI NIH HHS; R01 HL142028 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: COVID-19; CRISPR; GWAS; SARS-CoV-2; eQTL |
| تواريخ الأحداث: | Date Created: 20210421 Latest Revision: 20240403 |
| رمز التحديث: | 20240403 |
| مُعرف محوري في PubMed: | PMC8057256 |
| DOI: | 10.1101/2021.04.09.21255184 |
| PMID: | 33880488 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2021.04.09.21255184 |
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