دورية أكاديمية
أعرض في EDS

Late presentation for HIV remains a major health issue in Spain: Results from a multicenter cohort study, 2004-2018.

التفاصيل البيبلوغرافية
العنوان: Late presentation for HIV remains a major health issue in Spain: Results from a multicenter cohort study, 2004-2018.
المؤلفون: Rava M; Unit AIDS Research Network Cohort (CoRIS), National Center of Epidemiology (CNE), Health Institute Carlos III (ISCIII), Madrid, Spain., Domínguez-Domínguez L; 12 de Octubre University Hospital, Madrid, Spain., Bisbal O; 12 de Octubre University Hospital, Madrid, Spain., López-Cortés LF; Virgen del Rocío University Hospital, Sevilla, Spain., Busca C; La Paz University Hospital, Madrid, Spain., Antela A; University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain., González-Ruano P; Infanta Sofía University Hospital, Madrid, Spain., Hernández C; Príncipe de Asturias University Hospital, Alcalá de Henares, Madrid, Spain., Iribarren JA; Department of Infectious Diseases, University Hospital, IIS Biodonostia, San Sebastián, Spain., Rubio R; 12 de Octubre University Hospital, Madrid, Spain., Moreno S; Ramón y Cajal University Hospital, Madrid, Spain., Jarrín I; Unit AIDS Research Network Cohort (CoRIS), National Center of Epidemiology (CNE), Health Institute Carlos III (ISCIII), Madrid, Spain.
مؤلفون مشاركون: Cohort of the Spanish HIV/AIDS Research Network (CoRIS)
المصدر: PloS one [PLoS One] 2021 Apr 21; Vol. 16 (4), pp. e0249864. Date of Electronic Publication: 2021 Apr 21 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: HIV Infections/*diagnosis, Adult ; Anti-Retroviral Agents/therapeutic use ; CD4 Lymphocyte Count ; Cohort Studies ; Delayed Diagnosis ; Educational Status ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/mortality ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Risk Factors ; Spain/epidemiology ; Substance Abuse, Intravenous/pathology ; Survival Rate
مستخلص: Objectives: With the purpose of reducing the well-known negative impact of late presentation (LP) on people living with HIV (PLWH), guidelines on early HIV diagnosis were published in 2014 in Spain, but since then no data on LP prevalence have been published. To estimate prevalence and risk factors of LP and to evaluate their impact on the development of clinical outcomes in the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) during 2004-2018.
Methods: CoRIS is an open prospective multicenter cohort of PLWH, adults, naive to ART at entry. LP was defined as HIV diagnosis with CD4 count ≤350 cells/μL or an AIDS defining event (ADE). Multivariable Poisson regression models were used to estimate both prevalence ratios (PR) for the association of potential risk factors with LP and Incidence rate ratios (IRRs) for its impact on the development of the composite endpoint (first ADE, first serious non-AIDS event [SNAE] or overall mortality).
Results: 14,876 individuals were included. Overall, LP prevalence in 2004-2018 was 44.6%. Risk factors for LP included older age, having been infected through injection drug use or heterosexual intercourse, low educational level and originating from non-European countries. LP was associated with an increased risk of the composite endpoint (IRR: 1.34; 95%CI 1.20, 1.50), ADE (1.39; 1.18, 1.64), SNAE (1.22; 1.01, 1.47) and mortality (1.71; 1.41, 2.08).
Conclusions: LP remains a health problem in Spain, mainly among certain populations, and is associated with greater morbidity and mortality. Public policies should be implemented to expand screening and early diagnosis of HIV infection, for a focus on those at greatest risk of LP.
Competing Interests: We acknowledge that the project has been financed by Gilead Science, being Rafael Rubio and Santiago Moreno the PIs of the project. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
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المشرفين على المادة: 0 (Anti-Retroviral Agents)
تواريخ الأحداث: Date Created: 20210421 Date Completed: 20210928 Latest Revision: 20230920
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8059864
DOI: 10.1371/journal.pone.0249864
PMID: 33882093
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0249864