دورية أكاديمية
Bile acid sequestrants: a review of mechanism and design.
| العنوان: | Bile acid sequestrants: a review of mechanism and design. |
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| المؤلفون: | Feng Y; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China.; Pharmaceutical College, Henan University, Kaifeng, China., Li Q; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China.; Department of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China., Ou G; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China.; Department of Pharmacy, General Hospital of PLA, Beijing, China., Yang M; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China., Du L; Pharmaceutical College, Henan University, Kaifeng, China.; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China.; Department of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China. |
| المصدر: | The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2021 Jun 08; Vol. 73 (7), pp. 855-861. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0376363 Publication Model: Print Cited Medium: Internet ISSN: 2042-7158 (Electronic) Linking ISSN: 00223573 NLM ISO Abbreviation: J Pharm Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [Oxford] : Oxford University Press Original Publication: London : Pharmaceutical Society of Great Britain |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Hypercholesterolemia*/drug therapy , Hypercholesterolemia*/metabolism, Bile Acids and Salts/*metabolism , Cellulose/*pharmacology , Cyclodextrins/*pharmacology , Molecularly Imprinted Polymers/*pharmacology , Sequestering Agents/*pharmacology , Surface-Active Agents/*pharmacology, Anticholesteremic Agents/pharmacology ; Humans |
| مستخلص: | Objective: Bile acid sequestrants (BAS) are used extensively in the treatment of hypercholesterolaemia. This brief review aimed to describe the design and evaluation of three types of BAS: amphiphilic copolymers, cyclodextrin/poly-cyclodextrin and molecular imprinted polymers. The mechanisms underlying the action of BAS are also discussed. Key Findings: BAS could lower plasma cholesterol, improve glycemic control in patients with type 2 diabetes and regulate balance energy metabolism via receptors or receptor-independent mediated mechanisms. Different types of BAS have different levels of ability to bind to bile acids, different stability and different in-vivo activity. Conclusions: A growing amount of evidence suggests that bile acids play important roles not only in lipid metabolism but also in glucose metabolism. The higher selectivity, specificity, stability and in-vivo activity of BAS show considerable potential for lipid-lowering therapy. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: amphiphilic copolymers; bile acid sequestrants; cyclodextrin; glucose-lowering; lipid-lowering; molecularly imprinted polymers |
| المشرفين على المادة: | 0 (Anticholesteremic Agents) 0 (Bile Acids and Salts) 0 (Cyclodextrins) 0 (Molecularly Imprinted Polymers) 0 (Sequestering Agents) 0 (Surface-Active Agents) 0 (cyclodextrin polymer) 9004-34-6 (Cellulose) |
| تواريخ الأحداث: | Date Created: 20210422 Date Completed: 20211206 Latest Revision: 20211214 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/jpp/rgab002 |
| PMID: | 33885783 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2042-7158 |
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| DOI: | 10.1093/jpp/rgab002 |