دورية أكاديمية

Gastric Juice-Based Genotypic Methods for Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance Testing: A Systematic Review and Meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Gastric Juice-Based Genotypic Methods for Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance Testing: A Systematic Review and Meta-analysis.
المؤلفون: Si XB; Department of Gastroenterology, Beijing Jishuitan Hospital, Beijing, China;The Fourth Clinical College of Peking University, Beijing, China., Bi DY; The Fourth Clinical College of Peking University, Beijing, China., Lan Y; Department of Gastroenterology, Beijing Jishuitan Hospital, Beijing, China;The Fourth Clinical College of Peking University, Beijing, China., Zhang S; Department of Cardiology, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China., Huo LY; Department of Neurology, Beijing Haidian Hospital, Beijing, China.
المصدر: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology [Turk J Gastroenterol] 2021 Jan; Vol. 32 (1), pp. 53-65.
نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Aves Country of Publication: Turkey NLM ID: 9515841 Publication Model: Print Cited Medium: Internet ISSN: 2148-5607 (Electronic) Linking ISSN: 13004948 NLM ISO Abbreviation: Turk J Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : İstanbul,Turkey : Aves
Original Publication: Ankara : Turkish Society of Gastroenterology, 1995-
مواضيع طبية MeSH: Gastric Juice*/drug effects , Gastric Juice*/microbiology , Helicobacter Infections*/diagnosis , Helicobacter Infections*/drug therapy , Helicobacter Infections*/genetics , Helicobacter Infections*/microbiology , Helicobacter pylori*/genetics , Helicobacter pylori*/isolation & purification, Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Clarithromycin/pharmacology ; Clarithromycin/therapeutic use ; Drug Resistance, Microbial/drug effects ; Humans ; Microbial Sensitivity Tests ; Microbiological Techniques
مستخلص: Objective: To evaluate the diagnostic efficacy of gastric juice-based genotypic methods for Helicobacter pylori detection and antibiotic resistance testing.
Methods: We used electronic databases including Medline, Embase, Web of Science and the Cochrane Central Register of Controlled Trial for literature survey using keywords such as "gastric juice", "Helicobacter pylori" and their synonyms. The quality of the studies was assessed using QUADAS-2. Summary performance measures (sensitivity, specificity, positive predictive values, negative predictive values, diagnostic odds ratio, and area under the summary receiver operating characteristic curve) and HSROC curves were produced. In addition, fagan plots were applied to illustrate the relationship among the prior test probability, PLR/NLR, and posterior test probability.
Results: Our study cohort comprised eight studies with 1235 participants (617 participants of H. pylori infection and 618 participants of non-H. pylori infection). Pooled sensitivity and specificity with a corresponding 95% confidence interval (CI) of gastric juice-based genotypic methods reflected values of 94% (95%CI, 86% - 98%) and 98% (95%CI, 85% - 100%), respectively. The global sensitivity and specificity of clarithromycin resistance were 92% (95%CI, 85% - 96%) and 90% (95%CI, 80% - 95%), respectively.
Conclusion: Gastric juice-based genotypic methods can be used for diagnostic prediction of H. pylori infection as well as clarithromycin resistance testing.
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المشرفين على المادة: 0 (Anti-Bacterial Agents)
H1250JIK0A (Clarithromycin)
تواريخ الأحداث: Date Created: 20210424 Date Completed: 20220131 Latest Revision: 20220415
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8975514
DOI: 10.5152/tjg.2020.20025
PMID: 33893766
قاعدة البيانات: MEDLINE
الوصف
تدمد:2148-5607
DOI:10.5152/tjg.2020.20025